Medical Definition of Polyostotic fibrous dysplasia

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Polyostotic fibrous dysplasia: A disorder that features the replacement of multiple areas of bone by fibrous tissue, which may cause fractures and deformity of the legs, arms, and skull. A genetic disorder that is characterized by polyostotic fibrous dysplasia along with skin pigmentation and hormonal problems, with premature sexual development, is known as McCune-Albright's syndrome. The flat areas of increased skin pigment are called caf' au lait spots. The hormonal problems that can be related to polyostotic fibrous dysplasia include early puberty (with premature menstrual bleeding and development of breasts and pubic hair), thyroid abnormalities, and an increased rate of growth. Also known as McCune-Albright syndrome.

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Reviewed on 12/11/2018

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