Medical Definition of Asthma susceptibility gene

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Reviewed on 12/11/2018

Asthma susceptibility gene: One of the genes that predisposes a person to asthma.

A gene family that plays a major role in asthma susceptibility has been identified. This gene family, located at chromosome 5q23-35, is called TIM (T cell transmembrane, immunoglobulin and mucin) or Tapr (T cell and Airway Phenotype Regulator) . The TIM family of genes is involved in allergic response, asthma, and transplant tolerance. It controls the development of airway hyperreactivity (and the T cell production of interleukin 4 and 13). TIM-1 is also the receptor of the hepatitis A virus. This may explain the fact that hepatitis A virus infection decreases the chance asthma will develop.

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Asthma is a chronic respiratory disease. See Answer

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Reviewed on 12/11/2018