Medical Definition of Goodpasture syndrome

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Goodpasture syndrome: An autoimmune disease characterized by a combination of lung and kidney disease. Hallmarks of the disease are pulmonary hemorrhage (bleeding in the lungs) and glomerulonephritis (inflammation of the glomerulus) due to severe inflammation in the basement membranes of the alveolus of the lung and the glomerulus in the kidney, with the formation of antibodies to components of the basement membrane at both sites. Symptoms include cough with bloody sputum, bloody urine, decreased urine output, fatigue (weakness), and weight loss. Hypertension and swelling (edema) are also common findings on physical examination. The syndrome is also referred to as anti-glomerular basement membrane antibody disease.

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Reviewed on 10/30/2018

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