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It included 105 hemodialysis patients who were assessed for body-mass index or BMI (an estimate of body fat based on height and weight), waist size, mid-thigh muscle and abdominal fat. They were also tested to see how far they could walk in six minutes and completed questionnaires to assess their physical and mental health.
Patients with a higher BMI, large waist size and more abdominal fat did worse on the walking test. Those with more mid-thigh muscle -- an indicator of higher muscle mass -- had longer six-minute walking distances and better physical and mental health scores, according to the study. It was published online April 24 in the Clinical Journal of the American Society of Nephrology.
"Because this study shows that higher muscle mass is associated with better physical function and quality of life in dialysis patients, interventions such as increased physical activity that decrease fat mass and increase muscle mass are likely to improve physical function, quality of life and survival in dialysis patients," study author Dr. Srinivasan Beddhu, of the University of Utah, said in a journal news release.
"Such interventions need to be tested in clinical trials," Beddhu added.
The study only found an association between muscle mass and improved physical function for dialysis patients. It didn't prove cause and effect.
"The obesity paradox has been interpreted in earlier studies as fat is good. Some have even argued that weight loss should be discouraged in dialysis patients. But the situation is more nuanced," Beddhu said.
-- Robert Preidt
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SOURCE: Clinical Journal of the American Society of Nephrology, news release, April 24, 2014