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Researchers analyzed data from women in the U.S. Nurses' Health Study and men in the Health Professionals Study to determine if there was a link between weight, exercise and the risk for CTNNB1-positive or CTNNB1-negative colorectal cancer.
A higher body-mass index, or BMI (a measurement of body fat based on height and weight), was associated with an increased risk of CTNNB1-negative colorectal cancer, while physical activity was associated with a lower risk.
"Our results provide additional evidence for a causal role of obesity and a physically inactive lifestyle in a specific molecular subtype of colorectal cancer," Dr. Shuji Ogino, an associate professor of pathology at Dana-Farber Cancer Institute and an associate professor in the department of epidemiology at Harvard School of Public Health, said in a journal news release.
"If physicians are able to identify individuals who are prone to develop CTNNB1-negative cancer, then it would be possible to strongly recommend physical activity," Ogino added.
The findings also suggest that CTNNB1 could be a potential target for drugs to prevent and treat colorectal cancer in certain patients, Ogino said.
-- Robert Preidt
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