Whey Protein, Amino Acids May Boost Fat Loss

By Kathleen Doheny
WebMD Health News

Reviewed by Laura J. Martin, MD

Dec. 14, 2012 -- Adding essential amino acids and whey protein to a weight loss plan appears to increase fat loss, according to new research.

The study was done in older, obese adults, but the strategy may also work for younger adults, says researcher Robert Coker, PhD. He is an associate professor of geriatrics at the University of Arkansas for Medical Sciences, Little Rock.

In his new study, he compared two kinds of meal replacements. One was a protein replacement without essential amino acids. The other was a meal replacement with essential amino acids and whey protein.

The replacement with whey won.

"Essential amino acids, included as part of a meal replacement, along with whey protein, improved the synthesis of muscle and led to a greater loss of fat," he says.

Both groups lost about 7% of their total body weight. But the amino acids and whey group lost a greater percentage of fat to lean tissue.

Increasing fat loss during a weight loss program translates to a better and healthier body composition, experts say.

Adding Whey, Amino Acids: Study Details

Coker studied 12 obese men and women, all 65 to 80 years old.

They were assigned to the meal replacement group or the meal replacement with amino acids and whey group. All were allotted 1,200 calories a day.

Coker evaluated the 11 who completed the eight-week program to see the effect of each plan on fat and muscle.

The meal replacement with whey and amino acids did not preserve lean muscle tissue much better than the other meal replacement.

It did boost fat loss. At the start of the study, the meal-replacement-alone group was about 39% fat; at the study end, they averaged 37.5% fat. The group getting meal replacement with amino acids and whey had 41.8% body fat at the start but 36.3% at the end.

Body weight losses were similar -- both groups started at about 200 pounds and finished at an average of 185.

The whey and amino acid supplement ''increased muscle metabolism, and this may have triggered a greater reduction in body fat," Coker says.

Could the same strategy help younger adults? "I think the answer potentially is yes," Coker says. His study looked only at those 65-plus, and they were obese. But other research has indicated the approach could help younger people, he says.

Losing excess body fat is an important goal, Coker says. Among other effects, it promotes inflammation and insulin resistance, making the body less apt to use insulin effectively.

The product studied by Coker is not available to the public.

The study was supported by an NIH Small Business Innovation Research grant and other grants. The small business grant was administered through HealthSpan, which makes a whey protein product. Coker and other co-authors were compensated by HealthSpan as consultants for the grant.

Whey Protein for Fat Loss: Perspective

The new study echoes some of the findings of a previous study by Joy Frestedt, president and CEO of Frestedt Inc., a consulting firm for clinical trials and other research.

In her own study, she found that whey protein supplements helped adults lose more weight and more body fat than those not on the supplements.

She reviewed the new research for WebMD. The new study has limitations, she says. It was only eight weeks and there were just 11 finishers.

Even so, they went beyond her research in one way. "They actually biopsied the muscle," she says, to gauge the effect of the two approaches.

The product studied by Coker's group is not yet available, he says, but many whey protein supplements are sold over the counter.

To date, research suggests that whey protein may increase fat loss while helping to maintain muscle mass typically lost as pounds are shed, Frestedt says.


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SOURCES: Robert Coker, PhD, associate professor of geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock. Joy Frestedt, PhD, president and CEO, Frestedt Inc., St. Louis Park, Minn. Coker, R. Nutrition Journal, Dec. 11, 2012.

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