Medical Definition of Hemostasis, genetics of

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Hemostasis, genetics of: Inherited factors that play a role in hemostasis, the stoppage of blood flow through a blood vessel.

There is genetic regulation of proteins involved in hemostasis and atherothrombotic disorders, including myocardial infarction and stroke. People with a family history of coronary heart disease, for example, are more likely to develop the disease themselves, indicating that genetic factors may be important in this form of unwanted hemostasis.

Genetic factors contribute at least about half of the known variation in the concentrations of hemostatic factors (such as fibrinogen, factor VII, factor VIII, PAI-1, tissue plasminogen activator, factor XIIa, factor XIII A-subunit and B-subunit, and von Willebrand factor). The rest of the variation is due to environmental factors. (Ref.: Lancet 2001; 357: 101-05.)

CONTINUE SCROLLING OR CLICK HERE FOR RELATED ARTICLE
Reviewed on 12/11/2018

Health Solutions From Our Sponsors