Medical Definition of Y-linked gene

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Y-linked gene: A gene on the Y chromosome.

(Y-linkage is analogous to X-linkage (the presence of a gene on the X chromosome) in that it says a gene is on one of the sex chromosomes.)

It has often been said that little is known about genes that may be Y-linked. This is no longer true. As of the year 2012, about 3 dozen genes were known to be Y-linked including:

  • ASMTY (which stands for acetyl serotonin methyltransferase),
  • TSPY (testis-specific protein),
  • IL3RAY (interleukin-3 receptor),
  • SRY (sex-determining region),
  • TDF (testis determining factor),
  • ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
  • AMGL (amelogenin),
  • CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
  • ANT3Y (adenine nucleotide translocator-3 on the Y),
  • AZF2 (azoospermia factor 2),
  • BPY2 (basic protein on the Y chromosome),
  • AZF1 (azoospermia factor 1),
  • DAZ (deleted in azoospermia),
  • RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
  • RBM2 (RNA binding motif protein 2) and
  • UTY (ubiquitously transcribed TPR gene on Y chromosome).

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Reviewed on 12/11/2018

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