Medical Definition of Gene, Y-linked

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Gene, Y-linked: A gene on the Y chromosome.

(Y-linkage is analogous to X-linkage (the presence of a gene on the X chromosome) in that it says a gene is on one of the sex chromosomes.)

It has often been said that little is known about genes that may be Y-linked. This is no longer true. As of the year 2012, about three dozen genes were known to be Y-linked including:

  • ASMTY (which stands for acetyl serotonin methyltransferase),
  • TSPY (testis-specific protein),
  • IL3RAY (interleukin-3 receptor),
  • SRY (sex-determining region),
  • TDF (testis determining factor),
  • ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
  • AMGL (amelogenin),
  • CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
  • ANT3Y (adenine nucleotide translocator-3 on the Y),
  • AZF2 (azoospermia factor 2),
  • BPY2 (basic protein on the Y chromosome),
  • AZF1 (azoospermia factor 1),
  • DAZ (deleted in azoospermia),
  • RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
  • RBM2 (RNA binding motif protein 2) and
  • UTY (ubiquitously transcribed TPR gene on Y chromosome).

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Reviewed on 12/11/2018

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