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While methotrexate is normally removed from the blood by the kidneys, people who are prescribed high levels of methotrexate may develop kidney failure, leading to a buildup of the drug in the bloodstream.
Voraxaze is an enzyme that breaks down methotrexate into a form that is more easily eliminated from the body, the FDA said in a news release.
Voraxaze was evaluated in a clinical trial of 22 people. Ten of the 22 participants saw blood methotrexate levels fall below a critical level within 15 minutes. Among all participants, Voraxaze eliminated 95 percent of methotrexate, the FDA said.
Voraxaze is marketed by BTG International of West Conshohocken, Penn.
-- Scott Roberts
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