Study: Crohn's Disease, Ulcerative Colitis Less Likely in Women Living in Sunnier Regions
By Brenda Goodman, MA
WebMD Health News
Latest Digestion News
Reviewed by Laura J. Martin, MD
Jan. 11, 2012 -- Living in a sunny climate appears to reduce women's risk of developing inflammatory bowel disease, a large new study shows.
Yet little is known about the causes of these diseases, which are thought to involve a dysfunction of the immune system.
For the new study, researchers combed through data on more than 238,000 women taking part in the long-running Nurses' Health Study, which began in 1976.
The study collected information on where the women were living at birth, age 15, and age 30. It also recorded any diagnosis of an inflammatory bowel disease up to 2003.
Researchers also followed up with women who reported having inflammatory bowel disease and verified their diagnoses through medical records.
They found that women who lived in Southern regions that got a lot of sunlight had a 52% lower risk of being diagnosed with Crohn's disease by age 30 and a 38% lower risk of getting ulcerative colitis than those who lived in Northern regions.
That result held up even when researchers tried to rule out other things that might increase a person's risk for an inflammatory bowel disease, like having a family history.
"The differences are pretty drastic. That's what surprised us the most. Especially when it comes to Crohn's disease. We're seeing a 40% to 50% reduction in risk," says researcher Hamed Khalili, MD, a gastroenterologist at Massachusetts General Hospital in Boston.
The study is published in the journal Gut.
Shedding Light on IBD
This study confirms previous research from Europe, and it suggests that the amount of UV light exposure from sunlight may play an important role in the development of inflammatory bowel disease, though researchers aren't sure why.
One theory is that people in sunnier states may have higher exposure to UV light, leading to higher vitamin D levels. Vitamin D is known to help regulate immunity and inflammation.
Regional differences in environmental pollution or infections could offer other explanations.
"The study was well done," says Amnon Sonnenberg, MD, MSc, a gastroenterologist at Oregon Health & Science University, in Portland. "The authors are to be commended," says Sonnenberg, an expert on inflammatory bowel disease who was not involved in the study.
"We know quite well that there is a north-south gradient, and this north-south gradient applies to the American continent as well as to Europe," he says.
But he says the reasons behind the regional differences are far from clear cut.
For example, he says, studies have shown that miners -- who spend their working hours underground and out of the sunlight -- have less inflammatory bowel disease.
For that reason, he cautions patients against thinking that taking more vitamin D might help their symptoms or lessen their risk if they have a family member who's affected.
People tend to think "vitamin D is going to protect me," Sonnenberg says, "And there is absolutely no evidence for this."
SOURCES: Khalili, H. Gut, Jan. 11, 2011.Hamed Khalili, MD, gastroenterologist, Massachusetts General Hospital, Boston.Amnon Sonnenberg, MD, MSc, gastroenterologist, Oregon Health & Science University, Portland.
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