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Women Who Drink 4 or More Cups Daily Had 30% Lower Risk, but Lifestyle Matters, Too
By Kathleen Doheny
WebMD Health News
Reviewed by Laura J. Martin, MD
And if you prefer decaf, drinking two or more cups showed a trend toward reducing risk by about 22%. "Consistent with other reports, this study suggests that women who drink coffee, regular or decaf, are at reduced risk of endometrial cancer," says study researcher Edward Giovannucci, MD, ScD, professor of nutrition and epidemiology at Harvard School of Public Health.
Even so, Giovannucci says, "It's premature to recommend that women take up coffee to reduce the risk of endometrial cancer." He found a link, not cause and effect.
Tracking Coffee Habits and Cancer Risk
Giovannucci evaluated more than 67,000 women enrolled in the long-running Nurses' Health Study to examine the link between coffee and endometrial cancer risk.
During the 26-year follow-up, there were 672 cases of endometrial cancer.
The link between four or more cups of coffee and reduced risk of endometrial cancer was also stronger for:
"Both high estrogen and high insulin have been associated with higher risk of endometrial cancer," he says.
As for the stronger effect in smokers, he says, "We don't know why at this point."
It's not clear if the results would apply to those who drink coffee with sweeteners or cream, the researchers say. No information was given on how the women drank their coffee. Adding sugar or cream could offset any potential benefits.
Coffee and Endometrial Cancer Risk: Second Opinion
The results are "intriguing," says Marji McCullough, ScD, RD, strategic director of nutritional epidemiology for the American Cancer Society. She reviewed the study but was not involved in it.
The finding about a weaker link in people who have never smoked needs more study, she says.
But McCullough agrees the study does suggest that a woman who currently drinks coffee may be receiving benefit in terms of reducing her risk of endometrial cancer.
"If not, there are other important ways to reduce the risk of endometrial cancer, such as maintaining a healthy body weight and staying physically active," she tells WebMD.
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