Medical Definition of Antiestrogen

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Antiestrogen: A substance that can prevent the full expression of estrogen.

Antiestrogens act by exerting antagonistic effects on target tissues (androgens and progestogens act in this way) or by competing with estrogens for access to receptor sites located on the cell surface.

For example, the drug tamoxifen (brand name: Nolvadex) is an antiestrogen that is used in the treatment of breast cancer and to reduce the breast cancer incidence in high-risk women.

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Reviewed on 12/11/2018

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