Medical Definition of Pyridoxine

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Pyridoxine: One of the vitamin B6 group (which also includes pyridoxal and pyridoxamine) that is transformed in the body to pyridoxal phosphate, which functions as a coenzyme, a substance that enhances the action of an enzyme and thereby helps catalyze and speed a biochemical reaction. (A number of vitamins serve as coenzymes.)

The vitamin B6 group is especially important to the function of the central nervous system, skin, and blood. Vitamin B6 is involved in the formation of red blood cells since pyridoxal phosphate is the rate-limiting substance in making heme, a component of hemoglobin, the key oxygen-carrying pigment in red blood cells.

The diet rarely lacks vitamin B6. Most foods contain it. However, deficiency of vitamin B6 within the body may occur due to poor absorption of it from the intestine or inactivation of it by some drugs (e.g., anticonvulsants, corticosteroids, estrogens, isoniazid, and penicillamine). Other causes of vitamin B6 include alcoholism and conditions such as hyperthyroidism and diabetes that increase the metabolic demand, creating a relative shortage of vitamin B6.

Vitamin B6 deficiency causes convulsions in infants and anemia in adults. An outbreak of convulsions in infants followed the inadvertent destruction of vitamin B6 in infant formulas. Several genetic syndromes also involve problems with vitamin B6.

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Reviewed on 12/11/2018

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