Agenesis, sacral

View the Birth Control Options Slideshow

Medical Definition of Agenesis, sacral

Agenesis, sacral: Failure of formation of all or part of the sacrum (the lowest section of the spine).

Currarino syndrome is a condition characterized by the combination of:

  • Partial absence of the sacrum (the lowest portion of spine),
  • Anorectal (anal and rectal) abnormalities, and
  • An abnormal mass in front of the sacrum (due to a meningocoele or teratoma).

The malformations in Currarino syndrome are all in tissues that have their embryological origin in the tail bud and may reflect disturbances in its formation during early embryonic life. A mutation (change) in a gene called the HLXB9 homeobox gene has been identified as responsible for autosomal dominant Currarino syndrome, also known as hereditary sacral agenesis.


Quick GuideWomen's Health: Nutrition and Health Care Reform

Women's Health: Nutrition and Health Care Reform

Subscribe to MedicineNet's Women's Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Reviewed on 6/9/2016

Health Solutions From Our Sponsors