Medical Definition of Aldose reductase inhibitor

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Reviewed on 12/11/2018

Aldose reductase inhibitor: A class of drugs used to prevent eye and nerve damage in diabetes. Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body. It helps change glucose into a sugar alcohol called sorbitol. Too much sorbitol trapped in eye and nerve cells can damage these cells, leading to retinopathy (retinal disease) and neuropathy (nerve disease). Drugs that prevent or slow the action of aldose reductase may represent a means to prevent or delay these complications of diabetes.

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Reviewed on 12/11/2018