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Reviewed By Louise Chang, MD
"If confirmed in larger studies, the findings suggest that people with diabetic peripheral neuropathy might need more pain medication late at night.
"It could be that patients need more [pain] medication at night or that if they are taking a once-a-day medication, it should be taken in the evening," says Brett Stacey, MD, medical director of the Comprehensive Pain Center at Oregon Health & Science University in Portland.
But it's too early to make recommendations on the basis of this study, he tells WebMD.
The new findings were presented at the annual meeting of the American Pain Society.
Diabetes Nerve Damage: More Pain at Night
To begin to investigate whether the pain of diabetic peripheral neuropathy also has a daily pattern, researchers recruited 647 people who reported they'd been diagnosed with the condition.
For seven days, participants kept a diary recording the intensity of their pain every three hours, starting at 8 a.m. They were asked to rate their pain on a 10-point scale, where 10 equals the worst pain imaginable.
The average age of the participants was 54, and 58% were female. Nearly all (92%) were taking prescription or over-the-counter pain medication.
Results showed that average pain scores were highest at 11 p.m. and 8 p.m., when they were 4.65 and 4.53 points, respectively. They dropped to their daily low at 11 a.m., when they averaged 4.21 points.
The association between worse pain and evening hours remained after factors such as age, gender, and other health conditions were taken into account.
Still, the difference between the lowest and highest pain scores was too small to draw any firm conclusions, researchers say.
Diabetes Pain Study: "Hypothesis Generating"
The study has other limitations too, including the fact that participants were recruited via email and that they rated their own pain.
"It's hypothesis-generating," says Michael Clark, PhD, a pain specialist at the Haley VA Medical Center in Tampa, Fla.
Studies like this "tell us whether a hypothesis is worth pursuing," Clark tells WebMD.
"With pain management, we're trying to get away from treating patients based on averages, asking instead when do patients function best and when do they function worst," he says.
The new study was funded by GlaxoSmithKline, for whom Stacey serves as a consultant.
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Brett Stacey, MD, medical director, Comprehensive Pain Center, Oregon Health & Science University, Portland.
Michael Clark, PhD, Haley VA Medical Center, Tampa.
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