Medical Definition of Hemophagocytic Lymphohistiocytosis (HLH)

Hemophagocytic lymphohistiocytosis: A rare, cancer-like disorder in which both certain types of immune system cells (histiocytes and lymphocytes) start to proliferate and damage body tissues or organs. It can be an inherited condition, or it can occur as a result of immunosuppression (as in organ transplants) or infection. Most patients are young children; signs and symptoms include

Treatment is by chemotherapy and in some cases bone-marrow transplantation.

See also histiocytosis.

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Reviewed on 12/30/2019