Medical Definition of Subtelomeric

Subtelomeric: Below the telomere, the end of a chromosome.

For example, it has been reported that subtle subtelomeric rearrangements of the DNA are responsible for a significant proportion of unexplained cases of moderate to severe mental retardation (References: Lancet 1999;354:1659-1660,1676-1681).

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Reviewed on 9/7/2018