Study Shows Dysfunction in Reward Center of Brain Is Linked to ADHD Symptoms
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Reviewed By Louise Chang, MD
Sept. 8, 2009 -- A problem in the brain's reward center may be behind symptoms like inattention associated with attention deficit hyperactivity disorder (ADHD).
New research suggests this dysfunction in the brain's reward pathway interferes with how people experience reward and motivation. Dopamine is a chemical in the brain essential to normal functioning of the nervous system.
"These deficits in the brain's reward system may help explain clinical symptoms of ADHD, including inattention and reduced motivation, as well as the propensity for complications such as drug abuse and obesity among ADHD patients," says researcher Nora Volkow, MD director of the National Institute on Drug Abuse, in a news release.
ADHD is a childhood psychological disorder that may also persist into adulthood and affects 3%-5% of American adults.
Researchers say the results offer new insight into ADHD as well as help explain why people with ADHD may be more likely to abuse drugs or become obese.
The study, published in TheJournal of the American Medical Association, used positron emission tomography (PET) brain scans to measure markers of the brain's dopamine system in 53 non-medicated adults with ADHD and a comparison group of 44 healthy adults.
The results showed that compared to the healthy adults, those with ADHD had a reduction of dopamine receptors and transporters in two regions of the brain involved in processing reward and motivation.
"This pathway plays a key role in reinforcement, motivation, and in learning how to associate various stimuli with rewards," says Volkow. "Its involvement in ADHD supports the use of interventions to enhance the appeal and relevance of school and work tasks to improve performance."
"Our results also support the continued use of stimulant medications -- the most common pharmacological treatment for ADHD -- which have been shown to increase attention to cognitive tasks by elevating brain dopamine," Volkow says.
SOURCES: Volkow, N. TheJournal of the American Medical Association, Sept. 9, 2009; vol 302: pp 1084-1091. News release, American Medical Association. News release, U.S. Department of Energy, Brookhaven National Laboratory.
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