Medical Definition of Hypochloremia

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Hypochloremia: Low blood levels of chloride.

Chloride is the major anion found in the fluid outside of cells and in blood. An anion is the negatively charged part of certain substances such as table salt (NaCl) when dissolved in liquid. Sea water has almost the same concentration of chloride ion as human fluids.

The balance of chloride ion (Cl-) is closely regulated by the body. Significant decreases in chloride can have deleterious or even fatal consequences. Chloride is normally lost in the urine, sweat, and stomach secretions. Excessive loss can occur from heavy sweating, vomiting, and adrenal gland and kidney disease.

The normal serum range for chloride is 98 - 108 mmol/L.

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Reviewed on 12/27/2018

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