Scleroderma: Symptoms & Signs

Scleroderma is a disease of the connective tissue characterized by thickened skin, scarring of skin and other areas of the body (fibrosis), blood vessel problems, inflammation, and pain.

Signs and symptoms of scleroderma can vary in intensity and affect many different body parts. These can include

Cause of scleroderma

An autoimmune reaction associated with an overactive immune system causes scleroderma. Doctors do not understand the exact reason for the autoimmune reaction.

Other scleroderma symptoms and signs


Eczema Browse our medical image collection of allergic skin disorders such as psoriasis and dermatitis and more caused by allergies See Images

Subscribe to MedicineNet's Skin Care & Conditions Newsletter

By clicking "Submit," I agree to the MedicineNet Terms and Conditions and Privacy Policy. I also agree to receive emails from MedicineNet and I understand that I may opt out of MedicineNet subscriptions at any time.

Medically Reviewed on 12/18/2019
Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.