Scleroderma: Symptoms & Signs

Medically Reviewed on 12/18/2019

Scleroderma is a disease of the connective tissue characterized by thickened skin, scarring of skin and other areas of the body (fibrosis), blood vessel problems, inflammation, and pain.

Signs and symptoms of scleroderma can vary in intensity and affect many different body parts. These can include

Cause of scleroderma

An autoimmune reaction associated with an overactive immune system causes scleroderma. Doctors do not understand the exact reason for the autoimmune reaction.

Other scleroderma symptoms and signs


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.