- What is sargramostim, and how does it work (mechanism of action)?
- What is Leukine used for?
- What are the side effects of sargramostim?
- What is the dosage for sargramostim?
- What drugs or supplements interact with sargramostim?
- Is sargramostim safe to take if I'm pregnant or breastfeeding?
- What else should I know about sargramostim?
What is sargramostim, and how does it work (mechanism of action)?
Sargramostim is a man-made form of the naturally-occurring protein, granulocyte, macrophage-colony stimulating factor (GM-CSF). GM-CSF is produced in the body by the immune system and stimulates the formation of white blood cells, including the granulocyte and the macrophage. Granulocytes and macrophages take part in the inflammatory reaction. They are responsible for detecting and destroying harmful bacteria and some fungi. Sargramostim belongs to a class of drugs called colony-stimulating factors because of their ability to stimulate cells in the bone marrow to multiply and form colonies. Sargramostim is man-made. It is a product of the genetic engineering of genes from fungi and is produced by recombinant DNA technology in bacteria. Other colony stimulating factors are epoetin alfa (Epogen, Procrit) that stimulate the formation of red blood cells and filgrastim (Neupogen) that also stimulates the formation of granulocytes and macrophages. The FDA approved sargramostim in March 1991.
What brand names are available for sargramostim?
Is sargramostim available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for sargramostim?
What is Leukine used for?
What are the side effects of sargramostim?
The most common side effects while taking sargramostim are:
What is the dosage for sargramostim?
Sargramostim is administered intravenously or subcutaneously (under the skin). Sargramostim vials should not be shaken since the drug may be damaged, and bubbles may form that can prevent some of the drug from being drawn up into the syringe at the time of injection. Doses and duration of treatment vary depending on which condition it is used for. 250 mcg/m2/day given by intravenous injection is a typical adult dose for most uses.
What drugs or supplements interact with sargramostim?
Is sargramostim safe to take if I'm pregnant or breastfeeding?
There are no studies to determine if sargramostim is excreted into breast milk.
What else should I know about sargramostim?
What preparations of sargramostim are available?
Injectable Solution: 500 mcg/ml; Powder for Injection: 250 mcg/vial
How should I keep sargramostim stored?
Sargramostim should be stored at 2 C to 8 C (36 F to 46 F). Sargramostim should not be frozen.
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Sargramostim (Leukine) is a medication prescribed to increase the number of white blood cells in patients with low white blood cell counts (neutropenia). Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.
Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Leukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal. Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
Non-Hodgkin's lymphoma is cancer of the lymphatic system, a vital part of the body's immune system. Symptoms and signs include swollen lymph nodes, fever, night sweats, coughing, weakness, chest pain, unexplained weight loss, and abdominal pain. Treatment depends on which type of non-Hodgkin's lymphoma one has, the stage of the cancer, one's age, how fast the cancer is growing, and whether one has other health problems.
Neutropenia is a marked decrease in the number of neutrophils, neutrophils being a type of white blood cell (specifically a form of granulocyte) filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis. Signs and symptoms of neutropenia include gum pain and swelling, skin abscesses, recurrent ear and sinus infections, sore mouth, low-grad fever, pneumonia-like symptoms, and pain and irritation around the rectal area. Neutropenia has numerous causes, for example, infections (HIV, TB, mono); medications (chemotherapy); vitamin deficiencies (anemia); bone marrow diseases (leukemias), radiation therapy, autoimmune destruction of neutrophils, and hypersplenism. Treatment of neutropenia depends upon the cause and the health of the patient.
Treatment & Diagnosis
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.