SAPHO Syndrome: Symptoms & Signs

Medically Reviewed on 1/8/2022

SAPHO syndrome is a chronic condition affecting the skin, joints, and bone. It is characterized by the presence of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO). Synovitis is an inflammation of the joint lining. Pustulosis is a condition that causes fluid-filled blisters on the palms of the hands and soles of the feet. Hyperostosis is excessive growth of bone, and osteiytis is inflammation of bone.

Signs and symptoms of SAPHO syndrome include

The affected joints include both the spine and peripheral joints such as the fingers, wrists, or knees. Other associated signs and symptoms include acne of the skin and pustules of the palms of the hands and soles of the feet.

Cause of SAPHO Syndrome

The cause of SAPHO syndrome is not understood, but medical professionals believe it is genetic in nature.

Other sapho syndrome symptoms and signs

  • Acne
  • Joint Pain
  • Pustules of the Palms of the Hands and Soles of the Feet
  • Redness
  • Stiffness
  • Swelling
  • Warmth


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.