Blood of the Dragon, Croton lechleri, Drago, Dragon's Blood, Lan-Hiqui, Laniqui, Sang de Dragon, Sangre de Drago, Sangre de Dragon, Sangue de Agua, Sangue de Drago, SP 303, SP-303, Taspine.
Sangre de Grado is a tree that grows in the Amazon region of South America. The tree bark and sap are used to make medicine.
Sangre de Grado or SP-303, one of the chemicals it contains, is used for diarrhea associated with cholera, AIDS, traveling, or treatment with antibiotics. Sangre de Grado is also used for treating cancer, irritable bowel syndrome (IBS), viral respiratory infections, fever, hemorrhage, bleeding gums, wounds, broken bones, vaginal infections, hemorrhoids, a skin condition called eczema, and insect bites and stings. Other uses include treating ulcers of the mouth, throat, stomach, or intestine; supporting the body's tissue repair mechanisms; and as a general tonic.
Some people apply Sangre de Grado or SP-303 directly to the skin for treating herpes simplex virus (types 1 and 2). Some women use it for flushing the vagina before childbirth.
How does work?
Sangre de Grado appears to help diarrhea by slowing down the intestines. It might also prevent the movement of some viruses into cells.
Possibly Effective for...
- AIDS-related diarrhea. Some research shows that taking the chemical SP-303 (SB-Normal Stool Formula, ShamanBotanicals.com), which is isolated from Sangre de Grado, seems to reduce diarrhea in people with AIDS-related diarrhea.
- Herpes outbreaks (genital and anal). Research suggests that applying the chemical SP-303, which is isolated from Sangre de Grado, directly to the skin is effective for treating genital and anal herpes simplex outbreaks in people with AIDS. However, it does not seem to be helpful for herpes outbreaks that do not respond to acyclovir, a drug used to treat herpes infections.
- Traveler's diarrhea. Research shows that taking the chemical SP-303, which is isolated from Sangre de Grado, by mouth seems to be effective for treating symptoms of traveler's diarrhea.
Insufficient Evidence to Rate Effectiveness for...
- Insect bites and stings. Early research suggests that applying Sangre de Grado to the skin relieves the symptoms of insect bites (fire ants, wasps, bees) and reactions to plants in a group of pest control workers.
- Treating allergic skin reactions.
- Cancer treatment.
- Irritable bowel syndrome (IBS).
- Lung infections.
- Mouth and throat ulcers.
- Stomach and intestinal ulcers.
- Bleeding gums.
- Bone fractures.
- A skin condition called eczema.
- Other conditions.
It is POSSIBLY SAFE to apply SP-303, a chemical isolated from Sangre de Grado, directly to the skin or to take SP-303 by mouth. There is not enough information available to know if Sangre de Grado itself is safe to take for medical conditions.Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Sangre de Grado if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
A type of blood cancer called leukemia: Sangre de Grado might make this condition worse. Avoid using Sangre de Grado if you have leukemia.
The following doses have been studied in scientific research:
- For treating AIDS-related diarrhea: a Sangre de Grado extract containing 500 mg of SP-303 (SB-Normal Stool Formula) every 6 hours.
- For treating traveler's diarrhea: a Sangre de Grado extract containing 125-500 mg SP-303 (SB-Normal Stool Formula) 4 times daily for 2 days.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Carlin, L., Vaisberg, A. J., and Hammond, G. B. Isolation of sinoacutine from the leaves of Croton lechleri. Planta Med. 1996;62(1):90-91. View abstract.
Costa, M., Perles, E. C., Fujiwara, F. Y., and Imamura, P. M. Synthesis of methyl dihydrohardwickiate and its C-4 epimer. Structural amendment of natural crolechinic acid. Phytochemistry 2000;53(8):851-854. View abstract.
De, Marino S., Gala, F., Zollo, F., Vitalini, S., Fico, G., Visioli, F., and Iorizzi, M. Identification of minor secondary metabolites from the latex of Croton lechleri (Muell-Arg) and evaluation of their antioxidant activity. Molecules. 2008;13(6):1219-1229. View abstract.
Desmarchelier, C. J. and de Moraes Barros, S. B. Pharmacological activity of South American plants: effects on spontaneous in vivo lipid peroxidation. Phytother.Res. 2003;17(1):80-82. View abstract.
DiCesare, D., DuPont, H. L., Mathewson, J. J., Ashley, D., Martinez-Sandoval, F., Pennington, J. E., and Porter, S. B. A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. Am.J.Gastroenterol. 2002;97(10):2585-2588. View abstract.
Fayad, W., Fryknas, M., Brnjic, S., Olofsson, M. H., Larsson, R., and Linder, S. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS.One. 2009;4(10):e7238. View abstract.
Fischer, H., Machen, T. E., Widdicombe, J. H., Carlson, T. J., King, S. R., Chow, J. W., and Illek, B. A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells. J.Ethnopharmacol. 2004;93(2-3):351-357. View abstract.
Froldi, G., Zagotto, G., Filippini, R., Montopoli, M., Dorigo, P., and Caparrotta, L. Activity of sap from Croton lechleri on rat vascular and gastric smooth muscles. Phytomedicine. 2009;16(8):768-775. View abstract.
Gonzales, G. F. and Valerio, L. G., Jr. Medicinal plants from Peru: a review of plants as potential agents against cancer. Anticancer Agents Med.Chem. 2006;6(5):429-444. View abstract.
Jones, K. Review of sangre de drago (Croton lechleri)--a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research. J.Altern.Complement Med. 2003;9(6):877-896. View abstract.
Lopes, M. I., Saffi, J., Echeverrigaray, S., Henriques, J. A., and Salvador, M. Mutagenic and antioxidant activities of Croton lechleri sap in biological systems. J.Ethnopharmacol. 2004;95(2-3):437-445. View abstract.
Milanowski, D. J., Winter, R. E., Elvin-Lewis, M. P., and Lewis, W. H. Geographic distribution of three alkaloid chemotypes of Croton lechleri. J.Nat.Prod. 2002;65(6):814-819. View abstract.
Miller, M. J., MacNaughton, W. K., Zhang, X. J., Thompson, J. H., Charbonnet, R. M., Bobrowski, P., Lao, J., Trentacosti, A. M., and Sandoval, M. Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado. Am.J.Physiol Gastrointest.Liver Physiol 2000;279(1):G192-G200. View abstract.
Miller, M. J., Vergnolle, N., McKnight, W., Musah, R. A., Davison, C. A., Trentacosti, A. M., Thompson, J. H., Sandoval, M., and Wallace, J. L. Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado. J.Invest Dermatol. 2001;117(3):725-730. View abstract.
Pereira, U., Garcia-Le, Gal C., Le, Gal G., Boulais, N., Lebonvallet, N., Dorange, G., Lefeuvre, L., Gougerot, A., and Misery, L. Effects of sangre de drago in an in vitro model of cutaneous neurogenic inflammation. Exp.Dermatol. 2010;19(9):796-799. View abstract.
Porras-Reyes, B. H., Lewis, W. H., Roman, J., Simchowitz, L., and Mustoe, T. A. Enhancement of wound healing by the alkaloid taspine defining mechanism of action. Proc.Soc.Exp.Biol.Med. 1993;203(1):18-25. View abstract.
Risco, E., Ghia, F., Vila, R., Iglesias, J., Alvarez, E., and Canigueral, S. Immunomodulatory activity and chemical characterisation of sangre de drago (dragon's blood) from Croton lechleri. Planta Med. 2003;69(9):785-794. View abstract.
Rossi, D., Bruni, R., Bianchi, N., Chiarabelli, C., Gambari, R., Medici, A., Lista, A., and Paganetto, G. Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex. Phytomedicine. 2003;10(2-3):139-144. View abstract.
Sandoval, M., Okuhama, N. N., Clark, M., Angeles, F. M., Lao, J., Bustamante, S., and Miller, M. J. Sangre de grado Croton palanostigma induces apoptosis in human gastrointestinal cancer cells. J.Ethnopharmacol. 2002;80(2-3):121-129. View abstract.
Takami, Y., Uto, H., Takeshita, M., Kai, H., Akamatsu, E., Moriuchi, A., Hasegawa, S., Oketani, M., Ido, A., Kataoka, H., and Tsubouchi, H. Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90. Hepatol.Res. 2010;40(4):337-345. View abstract.
Tradtrantip, L., Namkung, W., and Verkman, A. S. Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol.Pharmacol. 2010;77(1):69-78. View abstract.
Tran, C. D., Butler, R. N., and Miller, M. J. The role of Amazonian herbal medicine Sangre de Grado in Helicobacter pylori infection and its association with metallothionein expression. Helicobacter. 2006;11(2):134-135. View abstract.
Williams, J. E. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado. Altern.Med.Rev. 2001;6(6):567-579. View abstract.
Barnard DL, Huffman JH, Meyerson LR, Sidwell RW. Mode of inhibition of respiratory syncytial virus by a plant flavonoid, SP-303. Chemotherapy 1993;39:212-7. View abstract.
Barnard DL, Smee DF, Huffman JH, et al. Antiherpesvirus activity and mode of action of SP-303, a novel plant flavonoid. Chemotherapy 1993;39:203-11. View abstract.
BioWorld Today. Shaman will sidestep FDA by selling product over internet website. Available at: http://www.bioworld.com. (Accessed 6 January 2000).
Chen ZP, Cai Y, Phillipson JD. Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon's blood. Planta Med 1994;60:541-5. View abstract.
Desmarchelier C, Witting Schaus F, Coussio J, Cicca G. Effects of Sangre de Drago from Croton lechleri Muell.-Arg. on the production of active oxygen radicals. J Ethnopharmacol 1997;58:103-8. View abstract.
Dicesare D, Dupont HL, Mathewson JJ, et al. A double-blind randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Mexico and Jamaica. Infectious Diseases Society of America Annual Meeting, 1998 (abstract).
Gabriel SE, Davenport SE, Steagall RJ, et al. A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion. Am J Physiol 1999;276:G58-G63. View abstract.
Gilbert BE, Wyde PR, Wilson SZ, Meyerson LR. SP-303 small-particle aerosol treatment of influenza A virus infection in mice and respiratory syncytial virus infection in cotton rats. Antiviral Res 1993;21:37-45. View abstract.
Holodniy M, Koch J, Mistal M, et al. A double blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS. Am J Gastroenterol 1999;94:3267-73. View abstract.
Miller MJ, Vergnolle N, Wallace JL, et al. Sangre de grado is a potent and unique inhibitor of neurogenic inflammation and promotes healing in experimental necrotizing enterocolitis. Pediatric Academic Soc and Acad Pediatrics Joint Mtg, May 12-6 2000:Abstract 979.
Orozco-Topete R, Sierra-Madero J, Cano-Dominguez C, et al. Safety and efficacy of Virend for topical treatment of genital and anal herpes simplex lesions in patients with AIDS. Antiviral Res 1997;35:91-103. View abstract.
Perdue GP, Blomster RN, Blake DA, Farnsworth NR. South American plants II: taspine isolation and anti-inflammatory activity. J Pharm Sci 1979;68:124-6. View abstract.
Pieters L, de Bruyne T, Claeys M, et al. Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferation. J Nat Prod 1993;56:899-906. View abstract.
Raintree Nutrition. Sangre de Grado website: www.rain-tree.com/sangre.htm (Accessed 31 January 2000).
Safrin S, McKinley G, McKeough M, et al. Treatment of acyclovir-unresponsive cutaneous herpes simplex virus infection with topically applied SP-303. Antiviral Res 1994;25:185-92. View abstract.
Sidwell RW, Huffman JH, Moscon BJ, Warren RP. Influenza virus-inhibitory effects of intraperitoneally and aerosol-administered SP-303, a plant flavonoid. Chemotherapy 1994;40:42-50. View abstract.
Styczynski J, Wysocki M. Alternative medicine remedies might stimulate viability of leukemic cells. Pediatr Blood Cancer 2006;46:94-8. View abstract.
USDA, ARS, National Genetic Resources Program. Germplasm Resources Information Network - (GRIN). Taxon: Croton lechleri mull. Arg website: www.ars-grin.gov/cgi-bin/npgs/html/tax_search.pl?croton+lechleri (Accessed 31 January 2000).
Vaisberg AJ, Milla M, Planas MC, et al. Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri. Planta Med 1989;55:140-3. View abstract.
Wyde PR, Ambrose MW, Meyerson LR, Gilbert BE. The antiviral activity of SP-303, a natural polyphenolic polymer, against respiratory syncytial and parainfluenza type 3 viruses in cotton rats. Antiviral Res 1993;20:145-54. View abstract.