What are the uses for sacubitril and valsartan?
What are the side effects of sacubitril and valsartan?
The most common side effects of Entresto are:
Possible serious side effects include:
- Heart Disease (Coronary Artery Disease) Slideshow Pictures
- Atrial Fibrillation Slideshow: Causes, Tests and Treatment
- Take the Heart Disease Quiz!
- What brand names are available for sacubitril and valsartan?
- Is sacubitril and valsartan available as a generic drug?
- Do I need a prescription for sacubitril and valsartan?
- What are the uses for sacubitril and valsartan?
- What are the side effects of sacubitril and valsartan?
- What is the dosage for sacubitril and valsartan?
- Which drugs or supplements interact with sacubitril and valsartan?
- What else should I know about sacubitril and valsartan?
What is the dosage for sacubitril and valsartan?
- The initial dose is 49/51 mg twice daily.
- The dose should be doubled after 2 to 4 weeks to the recommended maintenance dose of 97/103 mg twice daily.
Which drugs or supplements interact with sacubitril and valsartan?
- Combining Entresto with ACE inhibitors increases the risk of angioedema and other side effects. Combining aliskiren (Tekturna) with Entresto increases the risk of kidney failure, high blood potassium, and low blood pressure. Aliskiren should not be combined with Entresto.
- Combining Entresto with potassium-sparing diuretics (for example, spironolactone [Aldactone], triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.
- Increases in blood lithium (Eskalith, Lithobid) levels and lithium toxicity have occurred when lithium and ARBs were combined. Blood lithium levels should be monitored if lithium is combined with Entresto.
- Combining Entresto with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure.
What else should I know about sacubitril and valsartan?
What preparations of sacubitril and valsartan are available?
Tablets: 24/26 mg, 49/51 mg. 97/103 mg (sacubitril/valsartan)
How should I keep sacubitril and valsartan stored?
Entresto should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
Entresto (sacubitril and valsartan) is a combination drug prescribed to treat chronic heart failure. Entresto belongs to the drug class called angiotensin receptor neprilysin inhibitors (ARNIs). Side effects include
Multimedia: Slideshows, Images & Quizzes
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Take this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and...
Salt Quiz: Test Your Diet IQ
Do you love salt? Take the online Salt Quiz to get the facts about dietary salts and sodium in fruits, vegetables, processed...
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Picture of Heart Detail
The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an...
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
Lower Your Cholesterol, Save Your Heart
Need to lower your cholesterol levels? Use these smart diet tips to quickly and easily lower your blood cholesterol levels....
Heart-Healthy Diet: 25 Foods to Protect Your Cardiovascular System
See 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and...
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
Am I Having a Heart Attack? Symptoms of Heart Disease
Heart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs...
High-Fiber Super Foods: Whole Grains, Fruits, & More
Learn about high-fiber foods. From fresh fruits to whole grains, these fiber-rich foods can lower cholesterol, prevent...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Related Disease Conditions
12 Congestive Heart Failure Symptoms, Stages, Causes, and Life Expectancy
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease,...
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and...
Stress and Heart Disease
The connection between stress and heart disease is not clear. Stress itself may be a risk factor, or high levels of stress may...
How the Heart Works
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood...
Fitness: Exercise for a Healthy Heart
Regular exercise can help reduce the risk of heart disease. To achieve maximum benefits, do a mix of stretching exercise, aerobic...
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to...
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases...
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women...
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart...
Treatment & Diagnosis
Medications & Supplements
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.