What are the uses for sacubitril and valsartan?
- Entresto is used for reducing the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV).
- Entresto is combined with other heart failure medications and in place of an ACE inhibitor or other ARBs.
What brand names are available for sacubitril and valsartan?
Is sacubitril and valsartan available as a generic drug?
Do I need a prescription for sacubitril and valsartan?
What are the side effects of sacubitril and valsartan?
The most common side effects of Entresto are:
- Low blood pressure
- Increased potassium levels
Possible serious side effects include:
- Hives (angioedema)
- Kidney failure
- Serious allergic reactions
- Severe low blood pressure
- Reduced number of white blood cells
- Reduced number of platelets
- Muscle breakdown
- Fetal toxicity
What is the dosage for sacubitril and valsartan?
- The initial dose is 49/51 mg twice daily.
- The dose should be doubled after 2 to 4 weeks to the recommended maintenance dose of 97/103 mg twice daily.
Which drugs or supplements interact with sacubitril and valsartan?
- Combining Entresto with ACE inhibitors increases the risk of angioedema and other side effects. Combining aliskiren (Tekturna) with Entresto increases the risk of kidney failure, high blood potassium, and low blood pressure. Aliskiren should not be combined with Entresto.
- Combining Entresto with potassium-sparing diuretics (for example, spironolactone [Aldactone], triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.
- Increases in blood lithium (Eskalith, Lithobid) levels and lithium toxicity have occurred when lithium and ARBs were combined. Blood lithium levels should be monitored if lithium is combined with Entresto.
- Combining Entresto with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure.
What else should I know about sacubitril and valsartan?
What preparations of sacubitril and valsartan are available?
Tablets: 24/26 mg, 49/51 mg. 97/103 mg (sacubitril/valsartan)
How should I keep sacubitril and valsartan stored?
Entresto should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
Entresto (sacubitril and valsartan) is a combination drug prescribed to treat chronic heart failure. Entresto belongs to the drug class called angiotensin receptor neprilysin inhibitors (ARNIs). Side effects include dizziness, cough, increased potassium levels (hypokalemia), low blood pressure.
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The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood throughout your body to sustain life. It is a fist-sized muscle that beats (expands and contracts) 100,000 times per day, pumping a total of five or six quarts of blood each minute, or about 2,000 gallons per day.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
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Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Risk factors for heart disease include: Smoking High blood pressure High cholesterol Diabetes Family history Obesity Angina, shortness of breath, and sweating are just a few symptoms that may indicate a heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
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