sacubitril and valsartan

What are the uses for sacubitril and valsartan?

  • Entresto is used for reducing the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV).
  • Entresto is combined with other heart failure medications and in place of an ACE inhibitor or other ARBs.

What brand names are available for sacubitril and valsartan?


Is sacubitril and valsartan available as a generic drug?


Do I need a prescription for sacubitril and valsartan?


What are the side effects of sacubitril and valsartan?

The most common side effects of Entresto are:

Possible serious side effects include:

What is the dosage for sacubitril and valsartan?

  • The initial dose is 49/51 mg twice daily.
  • The dose should be doubled after 2 to 4 weeks to the recommended maintenance dose of 97/103 mg twice daily.

Which drugs or supplements interact with sacubitril and valsartan?


  • Combining Entresto with ACE inhibitors increases the risk of angioedema and other side effects. Combining aliskiren (Tekturna) with Entresto increases the risk of kidney failure, high blood potassium, and low blood pressure. Aliskiren should not be combined with Entresto.
  • Combining Entresto with potassium-sparing diuretics (for example, spironolactone [Aldactone], triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.
  • Increases in blood lithium (Eskalith, Lithobid) levels and lithium toxicity have occurred when lithium and ARBs were combined. Blood lithium levels should be monitored if lithium is combined with Entresto.
  • Combining Entresto with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure.

What else should I know about sacubitril and valsartan?

What preparations of sacubitril and valsartan are available?

Tablets: 24/26 mg, 49/51 mg. 97/103 mg (sacubitril/valsartan)

How should I keep sacubitril and valsartan stored?

Entresto should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).


Heart Disease: Symptoms, Signs, and Causes See Slideshow


Entresto (sacubitril and valsartan) is a combination drug prescribed to treat chronic heart failure. Entresto belongs to the drug class called angiotensin receptor neprilysin inhibitors (ARNIs). Side effects include dizziness, cough, increased potassium levels (hypokalemia), low blood pressure.

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