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- What brand names are available for rosiglitazone/metformin-oral?
- Is rosiglitazone/metformin-oral available as a generic drug?
- Do I need a prescription for rosiglitazone/metformin-oral?
- What are the uses for rosiglitazone/metformin-oral?
- What are the side effects of rosiglitazone/metformin-oral?
- What is the dosage for rosiglitazone/metformin-oral?
- Which drugs or supplements interact with rosiglitazone/metformin-oral?
- Is rosiglitazone/metformin-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about rosiglitazone/metformin-oral?
What are the uses for rosiglitazone/metformin-oral?
What are the side effects of rosiglitazone/metformin-oral?
The most common side effects include
Taking Avandamet with food may help lessen some of these side effects. Other commonly reported side effects include
Rare but serious side effects include new or
- worsening heart failure,
- heart attack,
- edema or swelling (water retention),
- weight gain,
- liver problems,
- macula edema (a diabetic eye disease with swelling in the back of the eye),
- bone fractures,
- low red blood cell count,
- low blood glucose (hypoglycemia), and
- ovulation (increasing the chance of pregnancy).
Metformin can cause a rare but serious condition known as lactic acidosis, a build-up of acid in the blood. Lactic acidosis can cause death and requires immediate treatment. Symptoms of lactic acidosis include
- unusual muscle pain,
- pain in the stomach,
- difficulty breathing,
- dizziness, and
- slow or irregular heartbeat.
Patients suspected of have signs or symptoms of lactic acidosis must seek emergency medical help.
Quick GuideDiabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating
What is the dosage for rosiglitazone/metformin-oral?
The dosage of Avandamet should be individualized based on patient response and tolerability. It is generally given in divided doses with meals.
For patients inadequately controlled on diet and exercise
- Generally, the recommended starting dose of Avandamet is 2/500 mg administered once or twice daily.
- A starting dose of 2/500 mg twice daily may be considered for patients with HbA1c >11% or fasting plasma glucose (FPG) >270 mg//dL.
- If patients are not adequately controlled after 4 weeks of treatment the dosage may be increased in increments of 2/500 mg as necessary.
- The maximum daily dose of Avandamet is 8/2,000 mg.
For patients inadequately controlled on rosiglitazone or metformin monotherapy
- The selection of the dose of Avandamet must be based on the patient's current doses of rosiglitazone and/or metformin.
- To switch to Avandamet for patients currently treated with metformin
- The usual starting dose of Avandamet is 4 mg rosiglitazone and base the metformin dose on the current dose of metformin.
- To switch to Avandamet for patients currently treated with rosiglitazone
- The usual starting dose of Avandamet is 1,000 mg metformin and the corresponding dose of rosiglitazone that the patient is taking.
The safety and efficacy of Avandamet has not been established in pediatric patients. Therefore, use of Avandamet in this patient population is not recommended.
Metformin-containing drugs may be safely used in patients with mild to moderate renal impairment. Renal function should be assessed before starting treatment and at least yearly.
Metformin should not be used by patients with an estimated glomerular filtration rate (eGFR) below 30 mL/minute/1.73 m2 and starting metformin in patients with an eGFR between 30-45 mL/minute/1.73 m2 is not recommended.
Metformin should be stopped at the time of or before administering iodinated contrast in patients with an eGFR between 30 and 60 mL/minute/1.73 m2; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Kidney function should be evaluated 48 hours after receiving contrast and metformin may be restarted if kidney function is stable.
Which drugs or supplements interact with rosiglitazone/metformin-oral?
Rosiglitazone is extensively metabolized or broken down by a group of liver enzymes known as CYP2C8. Gemfibrozil (Lopid), a known inhibitor of CYP2C8 may increase blood levels of rosiglitazone and consequently increase the risk of side effects. Concomitant use of agents that also inhibit CYP2C8 requires a reduction in the dose of rosiglitazone.
Rifampin (Rimactane or Rifadin), a known inducer of CYP2C8, increases the breakdown of rosiglitazone. Therefore, concomitant use of agents that induce CYP2C8 may decrease the effectiveness of rosiglitazone.
Drugs which cause blood glucose levels to increase may diminish the effectiveness of Avandamet therapy. These drugs include
Is rosiglitazone/metformin-oral safe to take if I'm pregnant or breastfeeding?
- Avandamet has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, Avandamet should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Avandamet is classified as FDA pregnancy risk category C.
- It is not known if Avandamet is excreted in breast milk. Due to the lack of safety data, Avandamet is not recommended for use in nursing mothers.
What else should I know about rosiglitazone/metformin-oral?
What preparations of rosiglitazone/metformin-oral are available?
Oral tablets containing Avandamet: 2/500, 4/500, 2/1,000, and 4/1,000 mg.
How should I keep rosiglitazone/metformin-oral stored?
- Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
- Tablets should be dispensed and stored in an air-tight, light-resistant container.
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Diabetes and Eye ProblemsDiabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
Diabetes and Kidney DiseaseIn the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
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Diabetes MellitusDiabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Take the Diabetes QuizTake the Diabetes Quiz and learn the causes, signs, symptoms, and types of this growing epidemic. What does diabetes have to do with obesity and diet? Learn about life as a diabetic.
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Foot Problems (Diabetes)Diabetes related foot problems can affect your health with two problems: diabetic neuropathy, where diabetes affects the nerves, and peripheral vascular disease, where diabetes affects the flow of blood. Common foot problems for people with diabetes include athlete's foot, fungal infection of nails, calluses, corns, blisters, bunions, dry skin, foot ulcers, hammertoes, ingrown toenails, and plantar warts.
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Hyperglycemia or high blood sugar is a serious health problem for diabetics. There are two types of hyperglycemia, 1) fasting, and 2)postprandial or after meal hyperglycemia. Hyperglycemia can also lead to ketoacidosis or hyperglycemic hyperosmolar nonketotic syndrome (HHNS). There are a variety of causes of hyperglycemia in people with diabetes. Symptoms of high blood sugar may include increased thirst, headaches, blurred vision, and frequent urination.Treatment can be achieved through lifestyle changes or medications changes. Carefully monitoring blood glucose levels is key to prevention.
Low blood sugar, or hypoglycemia, is a syndrome in which a person's blood sugar is dangerously low. People with type 1 and type 2 diabetes are at risk for this condition. There are other diseases that can cause a person's blood sugar levels to go too low, for example, pancreatitis, Cushing's syndrome, and pancreatic cancer. Symptoms and signs that your blood sugar levels are too low include:
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If your blood sugars become too have the following nearby as a quick treatment.
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Stroke Symptoms and Treatment
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic). Symptoms of a stroke may include
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Type 2 diabetes is a condition in which a person's pancreas does not produce enough insulin to meet the needs of the body. Causes of type 2 diabetes are a sedentary lifestyle, eating excess sugar and carbohydrates, lack of exercise, being overweight, and genetics. Symptoms of type 2 diabetes are often subtle, but may include fatigue, urine odor, unintentional
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