- What brand names are available for rosiglitazone/metformin?
- What are the uses for rosiglitazone/metformin?
- What are the side effects of rosiglitazone/metformin?
- What is the dosage for rosiglitazone/metformin?
- Which drugs or supplements interact with rosiglitazone/metformin?
- Is rosiglitazone/metformin safe to take if I'm pregnant or breastfeeding?
- What else should I know about rosiglitazone/metformin?
What brand names are available for rosiglitazone/metformin?
Is rosiglitazone/metformin available as a generic drug?
Do I need a prescription for rosiglitazone/metformin?
What are the uses for rosiglitazone/metformin?
What are the side effects of rosiglitazone/metformin?
The most common side effects include
Taking Avandamet with food may help lessen some of these side effects. Other commonly reported side effects include
Rare but serious side effects include new or
- worsening heart failure,
- heart attack,
- edema or swelling (water retention),
- weight gain,
- liver problems,
- macula edema (a diabetic eye disease with swelling in the back of the eye),
- bone fractures,
- low red blood cell count,
- low blood glucose (hypoglycemia), and
- ovulation (increasing the chance of pregnancy).
Metformin can cause a rare but serious condition known as lactic acidosis, a build-up of acid in the blood. Lactic acidosis can cause death and requires immediate treatment. Symptoms of lactic acidosis include
- unusual muscle pain,
- pain in the stomach,
- difficulty breathing,
- dizziness, and
- slow or irregular heartbeat.
Patients suspected of have signs or symptoms of lactic acidosis must seek emergency medical help.
What is the dosage for rosiglitazone/metformin?
The dosage of Avandamet should be individualized based on patient response and tolerability. It is generally given in divided doses with meals.
For patients inadequately controlled on diet and exercise
- Generally, the recommended starting dose of Avandamet is 2/500 mg administered once or twice daily.
- A starting dose of 2/500 mg twice daily may be considered for patients with HbA1c >11% or fasting plasma glucose (FPG) >270 mg//dL.
- If patients are not adequately controlled after 4 weeks of treatment the dosage may be increased in increments of 2/500 mg as necessary.
- The maximum daily dose of Avandamet is 8/2,000 mg.
For patients inadequately controlled on rosiglitazone or metformin monotherapy
- The selection of the dose of Avandamet must be based on the patient's current doses of rosiglitazone and/or metformin.
- To switch to Avandamet for patients currently treated with metformin
- The usual starting dose of Avandamet is 4 mg rosiglitazone and base the metformin dose on the current dose of metformin.
- To switch to Avandamet for patients currently treated with rosiglitazone
- The usual starting dose of Avandamet is 1,000 mg metformin and the corresponding dose of rosiglitazone that the patient is taking.
The safety and efficacy of Avandamet has not been established in pediatric patients. Therefore, use of Avandamet in this patient population is not recommended.
Metformin-containing drugs may be safely used in patients with mild to moderate renal impairment. Renal function should be assessed before starting treatment and at least yearly.
Metformin should not be used by patients with an estimated glomerular filtration rate (eGFR) below 30 mL/minute/1.73 m2 and starting metformin in patients with an eGFR between 30-45 mL/minute/1.73 m2 is not recommended.
Metformin should be stopped at the time of or before administering iodinated contrast in patients with an eGFR between 30 and 60 mL/minute/1.73 m2; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Kidney function should be evaluated 48 hours after receiving contrast and metformin may be restarted if kidney function is stable.
Which drugs or supplements interact with rosiglitazone/metformin?
Rosiglitazone is extensively metabolized or broken down by a group of liver enzymes known as CYP2C8. Gemfibrozil (Lopid), a known inhibitor of CYP2C8 may increase blood levels of rosiglitazone and consequently increase the risk of side effects. Concomitant use of agents that also inhibit CYP2C8 requires a reduction in the dose of rosiglitazone.
Rifampin (Rimactane or Rifadin), a known inducer of CYP2C8, increases the breakdown of rosiglitazone. Therefore, concomitant use of agents that induce CYP2C8 may decrease the effectiveness of rosiglitazone.
Drugs which cause blood glucose levels to increase may diminish the effectiveness of Avandamet therapy. These drugs include
Is rosiglitazone/metformin safe to take if I'm pregnant or breastfeeding?
- Avandamet has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, Avandamet should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Avandamet is classified as FDA pregnancy risk category C.
- It is not known if Avandamet is excreted in breast milk. Due to the lack of safety data, Avandamet is not recommended for use in nursing mothers.
What else should I know about rosiglitazone/metformin?
What preparations of rosiglitazone/metformin are available?
Oral tablets containing Avandamet: 2/500, 4/500, 2/1,000, and 4/1,000 mg.
How should I keep rosiglitazone/metformin stored?
- Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
- Tablets should be dispensed and stored in an air-tight, light-resistant container.
Avandamet (rosiglitazone and metformin) is a combination drug prescribed to treat type 2 diabetes in conjunction with exercise and diet. Side effects include upset stomach, vomiting, nausea, diarrhea, headache, dizziness. Drug interactions, dosage, storage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Type 2 Diabetes: Signs, Symptoms, Treatments
Learn about type 2 diabetes warning signs, symptoms, diagnosis, and treatment options. Find out why thirst, headaches, and...
Heart Healthy Diet: 25 Foods You Should Eat
What foods are heart healthy? Learn what foods help protect your cardiovascular system from heart attack, coronary heart disease,...
Super Tips to Boost Digestive Health: Bloating, Constipation, and More
Upset stomach? Some foods may be the culprits, and bad habits may be to blame. Treat your body right with these simple nutrition...
Diabetes: What Raises and Lowers Your Blood Sugar Level?
Want to lower your blood sugar? Learn to better control your glucose levels by preventing blood sugar spikes and swings to avoid...
Exercise and Fitness: 10 Budget-Friendly Exercise Gadgets
There are plenty of cheap and free ways to exercise. Learn about inexpensive ways to get in shape with the use of jump ropes,...
Juice Wars: Best and Worst Vegetable and Fruit Juices
Although the best kinds of juice deliver a bounty of vitamins, the worst are hardly better than liquid candy. Learn to...
Diabetes Nerve Pain: Improving Diabetic Peripheral Neuropathy
Learn how to cope with the symptoms of diabetic peripheral neuropathy through pain management exercises. Find relief for diabetic...
Exercises for Seniors: Tips for Core, Balance, Stretching
Exercise for seniors is important for healthy and successful aging. Learn about core strengthening, balance exercises, and...
Type 1 Diabetes (T1D): Symptoms, Causes, Treatments, Vs. Type 2
What is type 1 diabetes? There are new treatments for juvenile diabetes, and more people with diabetes can be treated than ever...
Learn about fat-fighting foods such as grapefruit, hot peppers, vinegar, and more. Discover the benefits along with surprising...
The Best Diet Tips: How to Lose Weight the Healthy Way
Learn to lose weight in a realistic way that works. Find healthy weight loss by eating right, sleeping more, understanding...
Bodybuilding Pictures: Muscle-Building Workout and Diet for Men
Want bulging biceps and a bigger chest? Our experts demonstrate the right moves to help men build bigger muscles with just two...
Build a Better Butt: Workouts for Slim and Shapely Glutes
Want a rear view that kicks butt? Discover the right exercises, cardio, and style choices that can help in the quest for the...
Sugar Addiction Facts: Cravings, Hidden Sugar, and More in Pictures
Learn about sugar addiction to see why we often crave sweets and binge on carbs. Learn how sugar affects the brain and get tips...
How Diabetes Can Affect Your Feet
Learn more about diabetes related foot problems. For people with diabetes, too much glucose in the blood can cause serious foot...
Food Cravings Slideshow: Chocolate, Carbs, Salt, Sugar
Learn which food cravings can wreck your diet. Whether your craving something creamy or crunchy, sweet or salty, food cravings...
Diet for Stress Management: Carbs, Nuts, and Other Stress-Relief Foods
While there are many ways to cope with stress, one strategy is to eat stress-fighting foods. Find out which foods to eat as part...
Healthy Eating: Snacks With 100 Calories or Less
The tastiest 100-calorie snacks offer quick, satisfying solutions to hunger. From edamame to ice cream, our experts help you with...
Salt & Low Sodium Diet Quiz
Do you love salt? Take the online Salt Quiz to get the facts about dietary salts and sodium in fruits, vegetables, processed...
Diet and Nutrition Quiz: Plans & Facts
Even if you think you're getting enough fruits and vegetables per day, how can you be sure? Take the Diet & Nutrition Quiz to...
Foods That Aren't as Healthy as You Think
It may seem healthy, but is it really? Many food frauds masquerade as diet food. See 11 foods that seem healthy but can be...
Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating
Discover the best and worst meals for diabetes-savvy dining. See how to avoid carbs and control your blood sugar with healthier...
Pictures of the 7 Most Effective Exercises to Do at the Gym or Home (and Tips to Improve Form)
These seven exercises deliver fitness results at home or in the gym. Start your training to better physical health with the most...
Fat and Fats Quiz: Fatty Food & Body Fat Percentage
Take this online Fat & Fats Quiz to learn if you really are what you eat!
Sugar Quiz: Facts on Diet & Sugar
Sugar lurks in surprising places. Take the Sugar Quiz to learn of the many ways sugar sneaks into your diet and see what you know...
Protein Quiz: Foods High in Protein
Protein is a staple in our diets, but what happens if we get too much? Take this quiz to find out the truth about protein and...
Food Portion Distortion Quiz: Correct Serving Size
Are your portions deceiving you? Take the Food Portion Distortion Quiz to find out how and why gigantic portions trick you into...
Type 2 Diabetes: Test Your Medical IQ
What causes type 2 diabetes? Can it be prevented? Take this online quiz and challenge your knowledge of this common condition....
Superfoods Quiz: List of Top Superfoods
Take our Superfoods Quiz! Get to know how unprocessed, raw, organic foods and healthy drinks are rich in nutrients and dietary...
Type 1 Diabetes Quiz: Test Your Medical IQ
What are the causes of type 1 diabetes? Take this quiz and challenge your knowledge of causes, symptoms, diagnosis and treatments...
Diabetes Quiz: Test Your Medical IQ
Take the Diabetes Quiz and learn the causes, signs, symptoms, and types of this growing epidemic. What does diabetes have to do...
Exercise and Fitness Quiz: Test Your IQ
Take our Exercise and Fitness Quiz and learn to maximize your fitness level with simple exercises that do not require major...
Gluten-Free Diet: Popular Gluten-Free Foods in Pictures
Starting a gluten free diet? Get the facts about gluten free foods -- with tips on what to avoid, what to enjoy, and delicious,...
13 Easy Ways to Eat More Greens
Learn 13 easy ways to add more greens to your diet. Discover how to add kale, spinach, broccoli rabe and more into your diet.
Diabetes Travel: Tips for Better Diabetes Control
Diabetes shouldn't stop you from traveling! Learn tips for packing diabetic supplies, controlling blood sugar while changing time...
Popular Dieting Myths and Facts
Can't tell fact from fiction about weight loss and healthy eating? Discover the truth behind some of the most common diet and...
No-Gym Workout in Pictures: Equipment, Routines, and More
Learn about this no-gym, at home quick workout. It can get you into great shape at home and shows the best moves for flat abs and...
Diabetes Diet: 11 Low-Sugar Drink Ideas
Searching for low-sugar drink ideas? This pictures slideshow has eleven beverages ideal for people with diabetes and those...
Diabetes: 15 Famous Celebrities With Diabetes
See pictures of celebrities that have been diagnosed with type 1 or type 2 diabetes including Mary Tyler Moore, Salma Hayek, and...
Slideshow: Diabetes Management in 10 Minutes
Learn 10 simple ways to better manage your diabetes. See tips for controlling blood sugar, diet and exercise and other helpful...
Low-Carb Snacks in Pictures
Interested in low-carb snacking? Here are some ideas about smart snacks that are filling and low in carbohydrates.
Pictures of the 7 Riskiest Workout Moves, and How to Improve Them
Working out is supposed to make you healthier--but some exercises can leave your body at risk of pain or injury. Some exercises...
12 Reasons to Love the Mediterranean Diet
The Mediterranean diet is a delicious way to eat healthy. We show you how to get the most from this diet with foods like olive...
Healthy Living: 20 Common Health Myths Exposed
Can vitamin C cure colds? Read as we dispel the half-truths and common myths of health, from X-rays to eggs, from the...
Diet Mistake Pictures: Crash Diets, High-Calorie Drinks, and More
Discover 10 common diet mistakes that may be preventing you from losing weight. Learn to avoid these diet blunders and watch the...
17 Must-Try Fitness Workouts in Pictures
Learn the latest exercise crazes such as TRX, pole dancing, Zumba, Kangoo jumps, boot camps, exergames and more that are designed...
Best and Worst-Appetizers: Spinach Dip, Potato Skins, and More
A tasty appetizer can be a great start to any meal--but some appetizers are diet disasters. Potato skins and cheese fries pack on...
Foods to Boost Your Energy and Mood
Learn which foods may boost your energy level and have a positive impact on your mood. Foods such as salmon, Brazil nuts, and...
Easy, Tasty Grilled Foods for Dinner Tonight in Pictures
Explore easy and tasty grilled foods. When your rushed to get dinner on the table, fire up the grill and use these delicious,...
10 Muscle-Building Exercises for Diabetes
Watch this slideshow on Diabetes and Exercise. If you have diabetes, see how strengthening your muscles with these 10 weight...
Benefits of Exercise: Fitness Facts Prove the Benefits of Working Out
The best way to lose weight? These fast facts show weight loss is possible for everyone trying to lose weight. From calories to...
Healthy Fast Food Options: 10 Tips for a Weight Loss Diet
What healthy fast food options are around you? Most fast food can't compare to the health of a well-planned, balanced diet. But...
Exercise and Fitness: The 7-Minute Workout
The 7-minute workout provides a free, convenient way to get and stay fit. Discover these short, quick exercises that use your own...
Off-Balance Core Moves: A Whole New Way to Work Out
Want a toned stomach or a winning tennis game? WebMD's pictures show 11 off-balance core exercises to help get you there.
Worst Fast-Food Sandwiches
Want to know what the good and bad fast-food sandwiches choices are? Our experts explore the nutrition facts of major restaurant...
Slideshow: 25 Ways to Get Ready for Swimsuit Season
Discover 25 ways to get ready for swimsuit season. See exercises, diet tips, and other healthy beauty fixes that will motivate...
Diet & Nutrition: The 10 Worst Foods in Your Fridge
What are the worst foods to eat in your fridge? From mayonnaise to ice cream and butter to processed lunch meats, learn about the...
Pictures of the Best Flat-Abs Moves for Men
Learn the best flat abs moves. If you want a ripped mid-section, learn how to go from flabby to flat abs with the right moves and...
Portion Control: Plate Photos to Lose Weight, Maintain Diet
Portion control can help with weight loss. The right plate amount can help you stick to a healthy diet. Learn to lose weight with...
Beach Body Essentials: Workouts, Flat Abs, and More With Pictures
Watch this slideshow on beach body essentials for men. Get yourself beach ready before you hit the sand with our visual guide to...
Pilates for Beginners in Pictures: Moves for Abs, Toning, and More
View 15 Pilates moves that get results. Flat abs are one highly prized result of a Pilates workout. See beginning moves to help...
Tips to Eat Healthy When You Dine Out in Pictures
Recognize the dangers of eating out and stay on your healthy diet at restaurants. Learn about healthy eating at restaurants,...
Related Disease Conditions
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Type 2 Diabetes Diet Plan
A type 2 diabetes diet or a type 2 diabetic diet is important for blood sugar (glucose) control in people with diabetes to prevent complications of diabetes. There are a variety of type 2 diabetes diet eating plans such as the Mediterranean diet, Paleo diet, ADA Diabetes Diet, and vegetarian diets.Learn about low and high glycemic index foods, what foods to eat, and what foods to avoid if you have type 2 diabetes.
High Blood Sugar (Hyperglycemia)
Hyperglycemia or high blood sugar is a serious health problem for diabetics. There are two types of hyperglycemia, 1) fasting, and 2)postprandial or after meal hyperglycemia. Hyperglycemia can also lead to ketoacidosis or hyperglycemic hyperosmolar nonketotic syndrome (HHNS). There are a variety of causes of hyperglycemia in people with diabetes. Symptoms of high blood sugar may include increased thirst, headaches, blurred vision, and frequent urination.Treatment can be achieved through lifestyle changes or medications changes. Carefully monitoring blood glucose levels is key to prevention.
Low Blood Sugar (Hypoglycemia)
Low blood sugar or hypoglycemia occurs when blood sugar is dangerously low and is often complication of type 1 and type 2 diabetes. Learn about symptoms, dangers, and treatment.
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic). Symptoms of a stroke may include weakness, numbness, double vision or vision loss, confusion, vertigo, difficulty speaking, or understanding speech. A physical exam, imaging tests, neurological exam, and blood tests may be used to diagnose a stroke. Treatment may include administration of clot-busting drugs, supportive care, and in some instances, neurosurgery. The risk of stroke can be reduced by controlling high blood pressure, high cholesterol, diabetes, and stopping smoking.
Type 2 Diabetes: Diagnosing Diabetes
Second Source WebMD Medical Reference
Type 2 Diabetes
Type 2 diabetes is a chronic condition that may be reversible with diet and lifestyle changes. Symptoms include excessive thirst, frequent urination, weight loss, fatigue, and an unusual odor to your urine. Most people don't know they have type 2 diabetes until they have a routine blood test. Treatment options include medications, a type 2 diabetes diet, and other lifestyle changes.
Diabetes Treatment: Medication, Diet, and Insulin
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with: insulin, exercise, and a diabetic diet. Type 2 diabetes is first treated with: weight reduction, a diabetic diet, and exercise. When these measures fail to control the elevated blood sugar, oral medications are used. If oral medications are still insufficient, insulin medications are considered.
How to Prevent Diabetes Naturally
Prediabetes is a condition in which a person has early symptoms of diabetes, but has not yet fully developed the condition. If prediabetes is not treated with lifestyle changes, the person could develop type 2 diabetes. Type 2 diabetes and prediabetes can be prevented with lifestyle changes, for example, eating a healthy diet, getting more exercise, reducing stress, quitting smoking, reducing or managing blood pressure and cholesterol, and managing any other health conditions or risk factors that you may have for developing type 2 diabetes.
Diabetes Foot Problems
Diabetes related foot problems can affect your health with two problems: diabetic neuropathy, where diabetes affects the nerves, and peripheral vascular disease, where diabetes affects the flow of blood. Common foot problems for people with diabetes include athlete's foot, fungal infection of nails, calluses, corns, blisters, bunions, dry skin, foot ulcers, hammertoes, ingrown toenails, and plantar warts.
Eye Problems and Diabetes
Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
Types of Diabetes Type 2 Medications
Type 2 diabetes oral medications are prescribed to treat type 2 diabetes in conjuction with lifestyle changes like diet and exercise. There are nine classes of drugs approved for the treatment of type 2 diabetes. Examples of type 2 oral diabetes medications include acarbose (Precose), chlorpropamide (Diabinese), glipizide (Glucotrol, Glucotrol XL), and metformin (Glucophage). Side effects, drug interactions, warnings and precautions, dosage, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the complications of diabetes. Information about exercise, diet, and medication will help you manage your diabetes better. Blood glucose reagent strips, blood glucose meters, urine glucose tests, tests for urinary ketones, continuous glucose sensors, and Hemoglobin A1C testing information will enable you to mange your diabetes at home successfully.
Treatment & Diagnosis
- Food Portion Distortion FAQs
- Diet & Nutrition FAQs
- Superfoods FAQs
- Sugar FAQs
- Fat and Fats FAQs
- Diabetes FAQs
- Salt FAQs
- Exercise and Fitness FAQs
- Protein FAQs
- Type 2 Diabetes FAQs
- Type 1 Diabetes FAQs
- Medication Disposal
- Dangers of Mixing Medications
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
Medications & Supplements
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.