- Type 2 Diabetes: Learn the Warning Signs
- Diabetes Friendly Dining
- Type 2 Diabetes: Test Your Medical IQ
- What is rosiglitazone, and how does it work (mechanism of action)?
- What brand names are available for rosiglitazone?
- Is rosiglitazone available as a generic drug?
- Do I need a prescription for rosiglitazone?
- What are the side effects of rosiglitazone?
- What is the dosage for rosiglitazone?
- Which drugs or supplements interact with rosiglitazone?
- Is rosiglitazone safe to take if I'm pregnant or breastfeeding?
- What else should I know about rosiglitazone?
What is rosiglitazone, and how does it work (mechanism of action)?
Rosiglitazone is an oral drug that reduces the amount of sugar (glucose) in the blood. It is used for treating patients with type 2 diabetes and is in a class of anti-diabetic drugs called thiazolidinediones. The other member of this class is pioglitazone (Actos). Insulin is a hormone produced by the pancreas that is important for controlling the levels of glucose in the blood. Insulin stimulates the cells of the body to remove glucose from the blood and thereby lowers the level of glucose in the blood. Patients with type 2 diabetes cannot make enough insulin or are resistant to the effects of insulin (insulin resistance). As a result, the cells in their bodies do not remove enough glucose from the blood, and the level of glucose rises. Rosiglitazone often is referred to as an "insulin sensitizer" because it attaches to the insulin receptors on cells throughout the body and causes the cells to become more sensitive (more responsive) to insulin and remove more glucose from the blood. At least some insulin must be produced by the pancreas in order for rosiglitazone to work. Rosiglitazone was approved by the FDA in May 1999.
What are the side effects of rosiglitazone?
AND PRECAUTIONS The most common side effects seen with rosiglitazone alone or in combination with metformin are:
- upper respiratory tract infection,
- back pain,
- hyperglycemia (elevated blood sugar),
- diarrhea, and
- hypoglycemia (low blood sugar).
Rosiglitazone has been shown to cause mild to moderate accumulation of fluid (edema) and can lead to heart failure. Patients who already have heart failure may develop worsening symptoms with rosiglitazone. Therefore, rosiglitazone should not be used by patients with heart failure. Rosiglitazone also has been associated with an increased risk of chest pain and heart attacks. The risk of heart attacks may be greater in those with established heart disease and taking nitrates or individuals receiving insulin.
Other important side effects include:
What is the dosage for rosiglitazone?
Rosiglitazone may be taken once or twice daily, with or without meals. Daily doses range from 4 to 8 mg either with or without other antidiabetic medications. There is no additional benefit for doses greater than 8 mg per day.
Which drugs or supplements interact with rosiglitazone?
Rifampin decreases concentrations in the blood of rosiglitazone by increasing its breakdown in the liver. Therefore, use of rifampin may decrease the effectiveness of rosiglitazone.
Rosiglitazone should not be combined with nitrates (for example, isosorbide dinitrate [Isordil Titradose, Dilatrate-SR, Isochron]). In clinical trials, the risk of chest pain and heart attacks was greater in individuals on nitrate therapy.
Is rosiglitazone safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of rosiglitazone in pregnant women. Rosiglitazone crosses the placenta and is detectable in fetal tissue.
It is unknown if rosiglitazone is secreted in breast milk. Therefore, the safety of rosiglitazone to nursing infants also is unknown.
What else should I know about rosiglitazone?
What preparations of rosiglitazone are available?
Tablets: 2, 4, and 8 mg.
How should I keep rosiglitazone stored?
Tablets should be kept at room temperature, 15 C -30 C (59 F -86 F).
Quick GuideDiabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating
Rosiglitazone (Avandia) is a drug prescribed for the treatment of type 2 diabetes combined with diet and exercise. Avandia is only prescribed under strict FDA regulations to patients who have not responded to treatment with other diabetic medications such as pioglitazone (Actos). Rosiglitazone (Avandia) is to be used in combination with exercise, smoking cessation, diet, and weight control for effective diabetes treatment. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are...
Fatty Liver (NASH)
Nonalcoholic fatty liver disease or NASH occurs due to the accumulation of abnormal amounts of fat within the liver. Fatty liver...
Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the...
Type 2 Diabetes
Type 2 diabetes is a condition in which a person's pancreas does not produce enough insulin to meet the needs of the body....
The main features of metabolic syndrome include insulin resistance, hypertension (high blood pressure), cholesterol...
Preventing Diabetes Naturally (Type 2, Diet, Causes, Symptoms)
Prediabetes is a condition in which a person has early symptoms of diabetes, but have not yet fully developed the condition. If...
Diabetes Treatment (Type 1 and Type 2 Medications and Diet)
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar....
Type 1 vs Type 2 Diabetes (Similarities and Differences)
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million...
Treatment & Diagnosis
- Metabolic Syndrome FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Avandia - Is It a Heart Risk?
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
- Metformin Still Best as First Type 2 Diabetes Treatment
- Which Diabetes Drug Is Best?
- More Evidence Diabetes Drug Actos Raises Bladder Cancer Risk a Bit
- Common Diabetes Meds Tied to Lower Risk for Parkinson's
- Diabetes Drugs Affect Hearts of Men, Women Differently
- FDA Mulls Lifting Tight Safety Limits on Diabetes Drug Avandia
- Type 2 Diabetes Progresses Faster in Kids, Study Finds
- Another Study Links Diabetes Drug Actos to Bladder Cancer
- Diabetes Drugs Avandia, Actos Linked to Vision Woes
- Diabetes Drug Actos Again Linked to Bladder Cancer
- Two-Drug Therapy Helped Kids With Type 2 Diabetes
- More Evidence Links Fractures to Diabetes Drugs
- FDA Panel Splits Over Avandia Ban
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information for Avandia.