sodium chloride, potassium chloride, sodium lactate and calcium (Lactated Ringer's Solution)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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What is ringers-lactated ringers solution-intravenous, and how does it work (mechanism of action)?

Lactated Ringer's is a sterile solution for fluid and electrolyte replenishment. It restores fluid and electrolyte balances, produces diuresis, and acts as alkalizing agent (reduces acidity). The FDA approved Ringer's solution in plastic containers in 1971.

What brand names are available for ringers-lactated ringers solution-intravenous?

Lactated Ringer's solution

Is ringers-lactated ringers solution-intravenous available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for ringers-lactated ringers solution-intravenous?

Yes

What are the uses for ringers-lactated ringers solution-intravenous?

Lactated Ringer's is used for balancing fluid and electrolytes and as an alkalizing agent.

What are the side effects of ringers-lactated ringers solution-intravenous?

Side effects of Lactated Ringer's solution are

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What is the dosage for ringers-lactated ringers solution-intravenous?

Adult dosing of Lactated Ringer's solution is as directed by the physician. Dosing is individualized based on the patient's age, weight, ongoing treatment, and clinical condition.

Safe and effective use of Lactated Ringer's solution in children is based on clinical practice.

Which drugs or supplements interact with ringers-lactated ringers solution-intravenous?

Lactated Ringer's solution should not be mixed with ceftriaxone (Rocephin) due to the significant risk of ceftriaxone and calcium precipitation.

Is ringers-lactated ringers solution-intravenous safe to take if I'm pregnant or breastfeeding?

: There are no adequate studies done on Lactated Ringer's solution to determine safe and effective use in pregnant women.

Use by women who are breastfeeding mothers has not been adequately evaluated.

What else should I know about ringers-lactated ringers solution-intravenous?

What preparations of ringers-lactated ringers solution-intravenous are available?

Lactated Ringer's solution is available in 250 ml, 500 ml, and 1000 ml in specific plastic containers.

  • Lactated Ringer's is composed of sodium chloride 6 g/L, sodium lactate 3.1 g/L, potassium chloride 0.3 g/L, and calcium chloride 0.2 g/L.
  • Lactated Ringer's contains ions of sodium 130 mEq/L, potassium 4 mEq/L, calcium 2.7 mEq/L, chloride 109 mEq/L, and lactate 28 mEq/L.
  • Lactated Ringer's has an osmolarity of 273 mOsmol/L, pH of 6.5, and caloric content of 9 kcal/L.

How should I keep ringers-lactated ringers solution-intravenous stored?

Store Lactated Ringer's solution at room temperature of 25 C, avoiding excessive heat. Brief exposure to up to 40 C does not affect the product.

REFERENCE: FDA Prescribing Information.

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Summary

Sodium chloride, potassium chloride, sodium lactate and calcium (Lactated Ringer's Solution) is a sterile solution used to replace fluids and electrolytes in patients with unbalanced blood fluid, and it also is used for an alkalizing agent. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to using this medication.

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Reviewed on 8/2/2016
References
REFERENCE: FDA Prescribing Information.

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