Reviewed on 6/11/2021
Other Name(s):

Chinese Foxglove, Chinese Rehmanniae Radix, Chinese RR, Di Huang, Dihuang, Gun-Ji-Whang, Japanese Rehmanniae Radix, Japanese RR, Jio, Juku-Jio, Kan-Jio, R. Glutinosa, Racine de Rehmannia, Rehmanniae, Rehmannia Glutinosa Oligosaccharide, Rehmannia glutinosa, Rehmannia Radac, Rehmanniae Radix, Rehmanniae Root, RR, Rhemannia Root, Rehmannia Steamed Root, RGAE, RGX, ROS, Saeng-Ji-Whang, Sho-Jio, Shu Di Huang, Sook-Ji-Whang, To-Byun.


Rehmannia is a plant. The root and parts that grow above the ground are used to make medicine. Rehmannia is commonly found in herbal combinations used in Traditional Chinese Medicine and Japanese Medicine.

Rehmannia is used for diabetes, “tired blood” (anemia), fever, weakened bones (osteoporosis), and allergies; and as a general tonic.

How does it work?

There is not enough information to know how rehmannia might work for any medical condition. However, some chemicals in rehmannia seem to affect the immune system and might reduce pain and swelling. Some chemicals in rehmannia also seem to lower blood sugar levels.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Anemia caused by bone marrow failure (aplastic anemia). Early research suggests that taking rehmannia along with the steroidal drug stanozolol might help improve symptoms of aplastic anemia better than stanozolol alone.
  • Chronic lung disease (chronic obstructive pulmonary disease, COPD). Early research suggests that taking a Chinese herbal decoction containing rehmannia root and angelica (tongfei mixture) by mouth along with oxygen treatment might improve oxygen levels during the night better than oxygen treatment alone in people with COPD and low oxygen levels.
  • Diabetes.
  • Fever.
  • “Weakened bones” (osteoporosis).
  • Allergies.
  • As a general tonic.
  • Other conditions.
More evidence is needed to rate the effectiveness of rehmannia for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

There is not enough information available to know if rehmannia is safe to take for medical conditions.


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Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking rehmannia if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Since rehmannia might affect blood sugar levels, people with diabetes should avoid or be very cautious about taking rehmannia. If you have diabetes and take rehmannia, monitor your blood sugar carefully.

Surgery: Because rehmannia might affect blood glucose levels, it might interfere with blood sugar control during and after surgery. Stop using rehmannia at least 2 weeks before a scheduled surgery.


Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Rehmannia might decrease blood sugar. There is concern that taking rehmannia with other medications for diabetes might cause blood sugar to decrease too much. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTabs, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.


The appropriate dose of rehmannia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for rehmannia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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