Is There a Connection Between Positive ANA and Miscarriage?

Ask the experts

I have had recurrent miscarriages. I just found out my ANA level was abnormal. Is there a connection and do I have a disease?

Doctor's response

It is not possible to determine whether or not you have a disease from this information.

There is a connection between ANAs (antinuclear antibodies) and recurrent miscarriages. ANAs suggest the possibility of autoimmune diseases. One of the most well-known autoimmune diseases, systemic lupus erythematosus (lupus) is associated with ANAs in 95% of patients. Women with lupus that become pregnant have a 15% risk of loss of pregnancy. Another autoimmune condition that is associated with both recurrent miscarriages and ANAs is the anti-phospholipid antibody syndrome. Women with this syndrome produce phospholipid antibodies (such as anticardiolipin antibody and lupus anticoagulant) that increase the risk of premature miscarriage. Women with recurrent miscarriages should be tested for phospholipid antibodies.

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Last Editorial Review: 1/11/2018