- What is rabeprazole, and how does it work (mechanism of action)?
- What brand names are available for rabeprazole?
- Is rabeprazole available as a generic drug?
- Do I need a prescription for rabeprazole?
- What are the uses for rabeprazole?
- What are the side effects of rabeprazole?
- What is the dosage for rabeprazole?
- Which drugs or supplements interact with rabeprazole?
- Is rabeprazole safe to take if I'm pregnant or breastfeeding?
- What else should I know about rabeprazole?
What is rabeprazole, and how does it work (mechanism of action)?
Rabeprazole is an oral drug that is used for the treatment of conditions caused by acid. It is in a class of drugs called proton pump inhibitors or PPIs which block the production of acid by the stomach. Other drugs in the same class include:
- lansoprazole (Prevacid),
- omeprazole (Prilosec),
- pantoprazole (Protonix),
- esomeprazole (Nexium), and
- dexlansoprazole (Dexilant).
PPIs are used for the treatment of acid-caused conditions such as stomach and duodenal ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome. Rabeprazole, like other PPIs, blocks the pump in the wall of the stomach that secretes acid into the stomach. By blocking the pump, the secretion of acid into the stomach is decreased, and this allows ulcers in the stomach and esophagus to heal. The FDA approved rabeprazole in August 1999.
What are the uses for rabeprazole?
Rabeprazole is used for treating ulcers of the stomach and duodenum, erosive or ulcerative gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome (in which there is overproduction of acid caused by tumors). It also is used with antibiotics for eradicating Helicobacter pylori infections of the stomach that, along with acid, are responsible for many ulcers.
What are the side effects of rabeprazole?
Rabeprazole like other PPIs has few side effects. The most common side effects are:
Other side effects include:
Quick GuideHeartburn: Causes, Symptoms, Remedies, Treatments
What is the dosage for rabeprazole?
Tablets should be swallowed whole and should not be crushed, split or chewed. Rabeprazole can be taken with or without meals since food has little effect on its absorption.
- For healing ulcerating GERD, the recommended dose for adults is 20 mg daily for 4-8 weeks. If healing does not occur after 8 weeks, another 8 week course may be considered. The recommended maintenance dose is 20 mg daily.
- Heartburn due to GERD is treated with 20 mg daily for 4 weeks and an additional 4 weeks if symptoms do not resolve.
- Ulcers are treated with 20 mg daily for 4 weeks.
- For the management of Zollinger-Ellison Syndrome, the starting dose for adults is 60 mg daily, and the dose is adjusted based on improvement in symptoms, healing of ulcers, or the effectiveness of acid suppression. Doses of 100 mg per day and 60 mg twice daily have been used in some patients with Zollinger-Ellison Syndrome.
- The regimen for eradication of Helicobacter pylori is rabeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1000 mg all given twice daily (morning and evening) for 7 days.
Which drugs or supplements interact with rabeprazole?
There have been reports of an increase in the effect of the blood thinner, warfarin (Coumadin), by rabeprazole which theoretically could lead to increased bleeding. Patients taking warfarin should be monitored more frequently if they begin taking rabeprazole. Rabeprazole may reduce the elimination of cyclosporin in the liver, thereby increasing cyclosporin levels in the blood and potentially leading to cyclosporin toxicity. The absorption of certain drugs may be affected by changes in stomach acidity. Rabeprazole and other PPIs that reduce stomach acid reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively. PPIs may decrease blood levels of atazanavir (Reyataz).
Is rabeprazole safe to take if I'm pregnant or breastfeeding?
Use in pregnant women has not been adequately evaluated.
Rabeprazole has not been studied in nursing women.
What else should I know about rabeprazole?
What preparations of rabeprazole are available?
Tablets (Delayed release): 20 mg
How should I keep rabeprazole stored?
Rabeprazole should be stored at room temperature, 15 C - 30 C (59 F - 86 F) and should be kept away from moisture.
Reference: FDA Prescribing Information
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Medications & Supplements
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- Drug Interactions
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Barrett's EsophagusBarrett's esophagus occurs as a complication of chronic gastroesophageal reflux disease (GERD), primarily in white males. GERD refers to the reflux of acidic fluid from the stomach into the esophagus (the swallowing tube), and is classically associated with heartburn. Learn the symptoms, causes, and treatments for Barrett's esophagus.
Indigestion (dyspepsia) can be caused by diseases or conditions that involve the gastrointestinal (GI) tract, and also by some diseases and conditions that do not involve the GI tract. Indigestion can be a chronic condition in which the symptoms fluctuate infrequency and intensity. Signs and symptoms that accompany indigestion include:
- Upper abdominal pain
- Abdominal bloating and distention
- Feeling full after eating only a small portion of food
Home remedies, medication, and lifestyle changes can help relieve and cure indigestion and its associated symptoms.
Esophagus PictureThe esophagus is a muscular tube connecting the throat (pharynx) with the stomach. See a picture of the Esophagus and learn more about the health topic.
Gastritis (acute and chronic) is an inflammation of the lining of the stomach Some people have no gastritis symptoms, but when they do occur they may include bloating, belching, loss of appetite, nausea, and vomiting. H. pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs) are the two main causes of gastritis. Alcohol, caffeine, and high-fat foods also can cause gastritis.
Fried, fatty, and spicy foods, and alcohol aggravate gastritis symptoms. Other stomach lining irritants that aggravate symptoms include cigarette smoking, acidic juices, caffeine, tomato products, peppers, and chili powder.
Foods that sooth gastritis symptoms, and that help reduce and stop H. pylori infection growth in the stomach include apples, onions, garlic, teas, green leafy vegetables, coconut water, and wheat bran.
Gastritis is diagnosed with endoscopy, blood tests, or stool tests. Some people get relief from gastritis symptoms with prescription and non-prescription antacids, histamine blockers like famotidine (Pepcid AC) or ranitidine (Zantac 75), or proton pump inhibitors (PPIs) like omeprazole (Prilosec) and esomeprazole (Nexium). These drugs will not cure gastritis.
Complications of gastritis include gastric cancers, MALT lymphoma, renal problems, and death
Gastroesophageal Reflux Disease (GERD)GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the esophagus. The symptoms of uncomplicated GERD are:
- regurgitation, and
Take the GERD QuizWho is at risk for developing GERD? Are you? Take this quiz to learn what GERD is, if you're at risk, and what you can do about it.
Heartburn (Reflux)Heartburn is a burning sensation experienced from acid reflux (GERD). Symptoms of heartburn include
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- a burning feeling in the chest.
- dietary habits,
- lifestyle habits, and
- medical causes.
- lifestyle changes,
- OTC medication,
- prescription medication, and
Helicobacter PyloriHelicobacter pylori (H. pylori) is a bacteria that causes chronic inflammation (gastritis) of the inner lining of the stomach, and also is the most common cause of ulcers worldwide. About 50% of people in the world carries or is infected with H. pylori. Common symptoms of H. pylori infection are occasional abdominal discomfort, bloating, belching or burping, and nausea and vomiting. H. pylori infection is difficult to erdicate, and treatment is with two or more antibiotics.
How to Stop Coughing
Coughing is a reflex that helps a person clear their airways of irritants. There are many causes of an excessive or severe cough including:
- Irritants like
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- air fresheners
- Medications like beta blockers and ACE inhibitors
- Medical conditions like
- the common cold
- lung cancer
- heart disease
Natural and home remedies that help cure and soothe a cough are:
Natural and home remedies to help cure and soothe a cough are:
- Stay hydrated
- Gargle saltwater
- Use cough drops or lozenges
- Use herbs and supplements like ginger, mint, licorice, and slippery elm
- Don't smoke
Over-the-counter products (OTC)to cure and soothe a cough include
- cough suppressants and expectorants, and
- anti-reflux drugs.
Prescription drugs that help cure a cough include
- narcotic medications,
- inhaled steroids, and
- anti-reflux drugs like proton pump inhibitors or PPIs, for example,
- omeprazole (Prilosec),
- rabeprazole (Aciphex), and
- pantoprazole (Protonix).
- Irritants like
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Peptic or stomach ulcers are ulcers are an ulcer in the lining of the stomach, duodenum, or esophagus. Ulcer formation is related to H. pylori bacteria in the stomach, use of anti-inflammatory medications, and cigarette smoking. Symptoms of peptic or stomach ulcers include:
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Treatment for stomach ulcers depends upon the cause.
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