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What is Quzyttir and how does it work?
What are the side effects of Quzyttir?
Common side effects of Quzyttir include:
- changes in taste,
- numbness and tingling,
- feeling hot,
- increased sweating,
- dry mouth,
- sore throat, and
The following clinically significant adverse reaction is described elsewhere in the labeling:
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Oral Cetirizine Hydrochloride
The following adverse reactions associated with the use of oral cetirizine hydrochloride were identified in clinical trials.
In clinical trials in patients 12 years and older the most common adverse reactions to oral cetirizine hydrochloride occurring with a 2% or greater incidence and greater than placebo were
In clinical trials in children 6 to 11 years of age with oral cetirizine hydrochloride the most common adverse reactions occurring with a 2% or greater incidence and greater than placebo were
- abdominal pain,
- nausea, and
Somnolence appeared to be dose related. Adverse reactions reported in placebocontrolled trials with oral cetirizine hydrochloride in pediatric patients 2 to 5 years were qualitatively similar in nature and generally similar in frequency to those reported in trials with children 6 to 11 years of age.
In placebo-controlled trials of pediatric patients 6 to 24 months of age, the incidences of adverse experiences were similar in the oral cetirizine hydrochloride and placebo treatment groups in each trial. In a trial of 1 week duration in children 6 to 11 months of age patients who received oral cetirizine hydrochloride exhibited greater irritability/fussiness than patients on placebo.
In a trial of 18 months duration in patients 12 months and older, insomnia occurred more frequently in patients who received oral cetirizine hydrochloride compared to patients who received placebo.
An additional randomized, double-blind, single dose study was conducted in 33 adults which showed similar safety results.
Subject-rated sedation scores were assessed at baseline, 1 hr, and/or 2 hrs, and/or "Readiness for Discharge”. Sedation was rated on a 0 to 3 scale (0 = none, to 3 = severe) with lower sedation scores indicating less sedation. Subjects in the Quzyttir treatment group reported less sedation at all time points compared to subjects treated with diphenhydramine.
What is the dosage for Quzyttir?
Quzyttir is a single-use injectable product for intravenous administration only. The recommended dosage regimen is once every 24 hours as needed for treatment of acute urticaria.
Administer Quzyttir as an intravenous push over a period of 1 to 2 minutes. Quzyttir is not recommended in pediatric patients less than 6 years of age with impaired renal or hepatic function.
Adults And Adolescents 12 Years Of Age And Older
The recommended dosage is 10 mg administered by intravenous injection.
Children 6 To 11 Years Of Age
The recommended dosage is 5 mg or 10 mg depending on symptom severity administered by intravenous injection.
Children 6 Months To 5 Years Of Age
The recommended dosage is 2.5 mg administered by intravenous injection.
Dosage Forms And Strengths
Quzyttir is a sterile, clear, colorless, non-pyrogenic, isotonic aqueous solution of cetirizine hydrochloride for intravenous injection; supplied in 2 mL size amber glass vials for single use. Each 2 mL size amber glass vial contains 1 mL drug solution with 10 mg cetirizine hydrochloride (equivalent to 8.42 mg of cetirizine).
Quzyttir (cetirizine hydrochloride injection), 10 mg/mL, pH between 4.5 to 6.5, is supplied as a sterile, clear, colorless, non-pyrogenic isotonic aqueous solution in single-use 2 mL amber glass vials. The following packaging configuration is available:
- NDC 70720-100-01: 10 mg/mL cetirizine hydrochloride single-use vial
- NDC 70720-100-10: Carton containing 1 single-use vial (10 mg/mL cetirizine hydrochloride)
- NDC 70720-100-25: Carton containing 25 single-use vials (10 mg/mL cetirizine hydrochloride)
Limitations Of Use
Quzyttir is not recommended in pediatric patients less than 6 years of age with impaired renal or hepatic function.
What drugs interact with Quzyttir?
No clinically significant drug interactions with oral cetirizine hydrochloride, the active ingredient in Quzyttir, have been found with theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin. There was a small decrease in the clearance of oral cetirizine hydrochloride caused by a 400-mg dose of theophylline; it is possible that larger theophylline doses could have a greater effect.
Is Quzyttir safe to take when pregnant or breastfeeding?
There are no adequate and well-controlled studies in pregnant women with cetirizine hydrochloride the active ingredient in Quzyttir. Cetirizine hydrochloride has been reported to be present in human breast milk. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Quzyttir and any potential adverse effects on the breastfed child from Quzyttir or from the underlying maternal condition.
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Quzyttir (cetirizine hydrochloride injection) is a histamine-1 (H1) receptor antagonist used to treat acute hives (urticaria) in adults and children 6 months of age and older.
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Related Disease Conditions
Hives, also called urticaria, is a raised, itchy area of skin. Most often the cause of hives is unknown. Sometimes it is a sign of an allergic reaction to food or medications, but the cause of the allergy (the allergen) is unknown. Dermatographism and swelling (angioedema) may accompany hives. Treatment to get rid of hives and alleviate symptoms typically includes antihistamines.
An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Cold, Flu, Allergy Treatments
Before treating a cold, the flu, or allergies with over-the-counter (OTC) medications, it's important to know what's causing the symptoms, which symptoms one wishes to relieve, and the active ingredients in the OTC product. Taking products that only contain the medications needed for relieving your symptoms prevents ingestion of unnecessary medications and reduces the chances of side effects.
Are Hives (Urticaria) Contagious?
Hives are not contagious are triggered by an allergic response to a substance. Symptoms and signs of hives include a raised, itchy red rash on the skin. An individual should seek medical care for hives if he or she develops dysphagia, wheezing, shortness of breath, or throat tightening.
Allergy Treatment Begins at Home
Avoiding allergy triggers at home is one of the best ways to prevent allergy symptoms. Controlling temperature, humidity, and ventilation are a few ways to allergy-proof the home. Cleaning, vacuuming, and using HEPA air filters also helps control allergies.
Drug Allergy (Medication Allergy)
Drug or medication allergies are caused when the immune system mistakenly creates an immune response to a medication. Symptoms of a drug allergic reaction include hives, rash, itchy skin or eyes, dizziness, nausea, diarrhea, fainting, and anxiety. The most common drugs that people are allergic to include penicillins and penicillin type drugs, sulfa drugs, insulin, and iodine. Treatment may involve antihistamines or corticosteroids. An EpiPen may be used for life-threatening anaphylactic symptoms.
Sinus Infection vs. Allergies
Both sinus infections and allergies (allergic rhinitis) cause symptoms such as runny or stuffy nose and fatigue. Sinus infection (known as sinusitis) is inflammation of the sinuses, caused by infection from bacteria, viruses, and/or fungi (molds). Allergic rhinitis occurs when certain allergies cause nasal symptoms. When a person with allergies breathes in an allergen, such as pollen, dust, or animal dander, symptoms such as runny or stuffy nose, itching, sneezing, and fatigue occur.
COVID-19 vs. Allergies
Though there is some overlap in allergy and COVID-19 signs and symptoms there are also significant differences. Symptoms that they have in common include headache, fatigue, tiredness, shortness of breath, wheezing, and sore throat. Fever does not occur with allergies but is one of the defining symptoms of COVID-19 infections.
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