- A Visual Guide to Heart Disease
- Medical Illustrations of the Heart Image Collection
- Take the Heart Disease Quiz!
- Is quinidine available as a generic drug?
- Do I need a prescription for quinidine?
- What are the uses for quinidine?
- What are the side effects of quinidine?
- What is the dosage for quinidine?
- Which drugs or supplements interact with quinidine?
- Is quinidine safe to take if I'm pregnant or breastfeeding?
- What else should I know about quinidine?
What are the uses for quinidine?
What are the side effects of quinidine?
The most common side effects are:
Other important side effects include:
- Irregular heartbeat
- Chest pain
- Skin rash
- Hearing changes (ringing or loss of hearing)
- Vision changes (blurred or light sensitivity)
- Unusual bleeding
If patients experience any of the above side effects, they should call their doctor immediately.
What is the dosage for quinidine?
- For adults, the dosage range for quinidine gluconate is from 648 to 2592 mg/day.
- For adults, the dosage range for quinidine sulfate is from 400 to 4000 mg/day.
- For adults, the dosage range for quinidine gluconate injection is 400 to 2400 mg/day.
Which drugs or supplements interact with quinidine?
- Azole antifungals such as ketoconazole (Nizoral), fluconazole (Diflucan), itraconazole (Sporanox PulsePak), voriconazole (VFEND), posaconazole (Noxafil), and protease inhibitor/antiretroviral drugs such as indinavir (Crixivan), and saquinavir (Invirase) should not be used with quinidine since their concomitant use can increase quinidine levels by inhibiting removal of quinidine by the liver. Increased quinidine levels can increase the risk of quinidine toxicity and cardiac arrhythmias.
- Phenothiazines such as thioridazine (Mellaril), an antipsychotic drug, and tricyclic antidepressants such as amitriptyline (Elavil, Endep) should not be used with quinidine since they can cause cardiac arrhythmias, and their use with quinidine increases the risk of cardiac arrhythmias.
- Quinidine increases the action of the blood thinner warfarin (Coumadin, Jantoven), due to synergistic effects and can lead to excessive blood thinning and bleeding. A decrease in warfarin dose usually is required. Blood levels of digoxin (Lanoxin) are raised by quinidine due to a reduction in removal or reduced distribution in the body of digoxin. This can give rise to intoxication with digoxin, and it is important to reduce the dose of digoxin to prevent toxicity.
- Removal of quinidine by the liver is accelerated by phenobarbital, phenytoin (Dilantin), and rifampin (Rifamate), requiring an increase in quinidine dose.
- With the exact mechanism not known, amiodarone (Cordarone), another type of antiarrhythmic drug, may decrease removal of quinidine by the kidneys or liver giving rise to elevated quinidine blood levels, which may result in life-threatening arrhythmias, including torsades de pointes. It is important, therefore, to decrease quinidine doses when it is given concomitantly with amiodarone.
- Cimetidine (Tagamet) increases quinidine levels by decreasing the elimination of quinidine giving rise to elevated quinidine serum levels that may lead to quinidine toxicity.
Is quinidine safe to take if I'm pregnant or breastfeeding?
What else should I know about quinidine?
What preparations of quinidine are available?
- Tablets: 200, 300, and 324 mg.
- Injections: 800 mg.
How should I keep quinidine stored?
- Quinidine should be stored at room temperature, 20 C - 25 C (68 F - 77 F).
- It should be dispensed in well-closed, light-resistant container.
Quinidine (Discontinued Brands: Cardioquine, Cin-Quin, Duraquin, Quinidex, Quinora, Quinact, Quinatime, Quinaglute, Quinalan) is an antiarrhythmic medication prescribed for abnormal heart rhythms such as atrial fibrillation, atrial flutter, and ventricular arrhythmias such as paroxysmal ventricular tachycardia. Quinidine also is prescribed to treat malaria. Side effects include:
Multimedia: Slideshows, Images & Quizzes
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
Atrial Fibrillation: Heart Symptoms, Diagnosis, & Afib Treatment
Atrial fibrillation is the most common type of abnormal heart rhythm. Atrial fibrillation or AF can lead to serious heart...
Atrial Fibrillation (A-Fib) Quiz: Test Your Medical IQ
Learn the causes, symptoms, and treatments of the common heart abnormality known as atrial fibrillation (A-fib)....
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Heart Disease: Symptoms, Signs, and Causes
What is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest...
Picture of Heart Detail
The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an...
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
High-Fiber Super Foods: Whole Grains, Fruits, & More
Learn about high-fiber foods. From fresh fruits to whole grains, these fiber-rich foods can lower cholesterol, prevent...
Heart-Healthy Diet: 25 Foods to Protect Your Cardiovascular System
See 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and...
12 Reasons to Love the Mediterranean Diet in Pictures
The Mediterranean diet is a delicious way to eat healthy. We show you how to get the most from this diet with foods like olive...
Worst-Appetizer Pictures: Spinach Dip, Potato Skins, and More
A tasty appetizer can be a great start to any meal--but some appetizers are diet disasters. Potato skins and cheese fries pack on...
Easy, Tasty Grilled Foods for Dinner Tonight in Pictures
Explore easy and tasty grilled foods. When your rushed to get dinner on the table, fire up the grill and use these delicious,...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Related Disease Conditions
How the Heart Works
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood...
Lupus (Systemic Lupus Erythematosus or SLE)
Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease....
Premature Ventricular Contractions (PVCs, PVC)
Premature ventricular contractions (PVCs, PVC) are premature heartbeats originating from the ventricles of the heart. PVCs are...
Thrombocytopenia (Low Platelet Count)
Thrombocytopenia (low platelet count) refers to a decreased number of platelets in the blood. Symptoms of thrombocytopenia...
Malaria is a disease that is spread by the bite of an infected Anopheles mosquito. Malaria symptoms include fever, chills,...
Atrial Fibrillation (AFib) Symptoms, ECG, and Treatment Medications
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm which involves irregular and often rapid beating of the...
Paroxysmal Supraventricular Tachycardia (PSVT)
Paroxysmal supraventricular tachycardia (PSVT) is an abnormal conduction of electricity in particular areas of the heart. PSVT...
Abnormal Heart Rhythms (Heart Rhythm Disorders)
Heart rhythm disorders vary from minor palpitations, premature atrial contractions (PACs), premature ventricular contractions...
Palpitations (Causes and Symptoms)
Palpitations are uncomfortable sensations of the heart beating hard, rapidly, or irregularly. Some types of palpitations are...
Atrial Fibrillation Symptoms (AFib Warning Signs)
Atrial fibrillation or AFib is a type of hear rhythm abnormality. Early warning signs and symptoms of atrial fibrillation...
Atrial Fibrillation (AFib) Treatment Drugs
Atrial fibrillation (also called Afib or Afib) is heart rhythm disorder that causes irregular, and often, a rapid heartbeat. The...
Treatment & Diagnosis
- Heart Disease FAQs
- Atrial Fibrillation A-Fib FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.