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What is quinidine?
Quinidine is an antiarrhythmic agent and antimalarial drug.
Is quinidine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for quinidine?
What are the side effects of quinidine?
The most common side effects are:
Other important side effects include:
- Irregular heartbeat
- Chest pain
- Skin rash
- Hearing changes (ringing or loss of hearing)
- Vision changes (blurred or light sensitivity)
- Unusual bleeding
If patients experience any of the above side effects, they should call their doctor immediately.
What is the dosage for quinidine?
- For adults, the dosage range for quinidine gluconate is from 648 to 2592 mg/day.
- For adults, the dosage range for quinidine sulfate is from 400 to 4000 mg/day.
- For adults, the dosage range for quinidine gluconate injection is 400 to 2400 mg/day.
Which drugs or supplements interact with quinidine?
- Azole antifungals such as ketoconazole (Nizoral), fluconazole (Diflucan), itraconazole (Sporanox PulsePak), voriconazole (VFEND), posaconazole (Noxafil), and protease inhibitor/antiretroviral drugs such as indinavir (Crixivan), and saquinavir (Invirase) should not be used with quinidine since their concomitant use can increase quinidine levels by inhibiting removal of quinidine by the liver. Increased quinidine levels can increase the risk of quinidine toxicity and cardiac arrhythmias.
- Phenothiazines such as thioridazine (Mellaril), an antipsychotic drug, and tricyclic antidepressants such as amitriptyline (Elavil, Endep) should not be used with quinidine since they can cause cardiac arrhythmias, and their use with quinidine increases the risk of cardiac arrhythmias.
- Quinidine increases the action of the blood thinner warfarin (Coumadin, Jantoven), due to synergistic effects and can lead to excessive blood thinning and bleeding. A decrease in warfarin dose usually is required. Blood levels of digoxin (Lanoxin) are raised by quinidine due to a reduction in removal or reduced distribution in the body of digoxin. This can give rise to intoxication with digoxin, and it is important to reduce the dose of digoxin to prevent toxicity.
- Removal of quinidine by the liver is accelerated by phenobarbital, phenytoin (Dilantin), and rifampin (Rifamate), requiring an increase in quinidine dose.
- With the exact mechanism not known, amiodarone (Cordarone), another type of antiarrhythmic drug, may decrease removal of quinidine by the kidneys or liver giving rise to elevated quinidine blood levels, which may result in life-threatening arrhythmias, including torsades de pointes. It is important, therefore, to decrease quinidine doses when it is given concomitantly with amiodarone.
- Cimetidine (Tagamet) increases quinidine levels by decreasing the elimination of quinidine giving rise to elevated quinidine serum levels that may lead to quinidine toxicity.
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Is quinidine safe to take if I'm pregnant or breastfeeding?
What else should I know about quinidine?
What preparations of quinidine are available?
- Tablets: 200, 300, and 324 mg.
- Injections: 800 mg.
How should I keep quinidine stored?
- Quinidine should be stored at room temperature, 20 C - 25 C (68 F - 77 F).
- It should be dispensed in well-closed, light-resistant container.
Quinidine (Discontinued Brands: Cardioquine, Cin-Quin, Duraquin, Quinidex, Quinora, Quinact, Quinatime, Quinaglute, Quinalan) is an antiarrhythmic medication prescribed for abnormal heart rhythms such as atrial fibrillation, atrial flutter, and ventricular arrhythmias such as paroxysmal ventricular tachycardia. Quinidine also is prescribed to treat malaria. Review side effects, drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information prior to taking this medication.
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The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood throughout your body to sustain life. It is a fist-sized muscle that beats (expands and contracts) 100,000 times per day, pumping a total of five or six quarts of blood each minute, or about 2,000 gallons per day.
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Atrial fibrillation (AFib) is a heart rhythm disorder that causes irregular and often rapid heartbeat. The medications to treat AFib include beta-blockers, blood thinners, and heart rhythm drugs. Atrial fibrillation drugs can cause serious side effects like seizures, vision changes, shortness of breath, fainting, other abnormal heart rhythms, excessive bleeding while coughing or vomiting, blood in the stool, and bleeding into the brain.
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Atrial Fibrillation (AFib)
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm, which involves irregular and often rapid beating of the heart. Symptoms may include heart palpitations, dizziness, fainting, fatigue, shortness of breath, and chest pain. Atrial fibrillation treatment may include medication or procedures like cardioversion or ablation to normalize the heart rate.
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Heart rhythm disorders vary from minor palpitations, premature atrial contractions (PACs), premature ventricular contractions (PVCs), sinus tachycardia, and sinus bradycardia, to abnormal heart rhythms such as tachycardia, ventricular fibrillation, ventricular flutter, atrial fibrillation, atrial flutter, paroxysmal supraventricular tachycardia (PSVT), Wolf-Parkinson-White syndrome, brachycardia, or heart blocks. Treatment is dependent upon the type of heart rhythm disorder.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.