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- What is quinapril, and how does it work (mechanism of action)?
- What brand names are available for quinapril?
- Is quinapril available as a generic drug?
- Do I need a prescription for quinapril?
- What are the side effects of quinapril?
- What is the dosage for quinapril?
- Which drugs or supplements interact with quinapril?
- Is quinapril safe to take if I'm pregnant or breastfeeding?
- What else should I know about quinapril?
What is quinapril, and how does it work (mechanism of action)?
Quinapril belongs in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors are used for treating high blood pressure and heart failure and for preventing kidney failure due to high blood pressure and diabetes. Other drugs in this class are enalapril (Vasotec), ramipril (Altace), captopril (Capoten), fosinopril (Monopril), benazepril (Lotensin), lisinopril (Zestril, Prinivil), moexipril (Univasc) and trandolapril (Mavik). ACE is important because it produces angiotensin II. Angiotensin II contracts the muscles of the arteries in the heart and the rest of the body, narrowing the arteries and thereby elevating blood pressure. In the kidney, the narrowing caused by angiotensin II decreases blood flow and increases the arterial filtration pressure in the kidney. ACE inhibitors such as quinapril lower blood pressure by inhibiting the formation of angiotensin II, thereby relaxing the arterial muscles and enlarging the arteries. This increases the flow of blood and oxygen to the heart so that it can pump blood more efficiently. The enlargement of the arteries elsewhere in the body also makes it easier for the heart to pump blood. This is particularly beneficial when there is heart failure. In the kidneys ACE inhibitors increase blood flow and reduce the filtration pressure in the kidneys. Quinapril was approved by the FDA in November 1991.
What are the side effects of quinapril?
Quinapril is generally well tolerated, and side effects are usually mild and transient. A dry, persistent cough has been reported with the use of quinapril and other ACE inhibitors. Coughing resolves after discontinuing the medication.
Other side effects include:
- abdominal pain,
- loss of taste,
- loss of appetite,
- nausea, vomiting,
- fainting, and
- numbness or tingling in the hands or feet.
Quinapril and other ACE inhibitors may also cause kidney failure and increased levels of potassium in the blood. The most serious but very rare side effects are liver failure and angioedema (swelling of lips and throat).
Quick GuideHow to Lower Blood Pressure: Exercise Tips
What is the dosage for quinapril?
The recommended dose for treating high blood pressure is 10-80 mg a day as a single dose or in two doses every 12 hours. Start at 5 to 20 mg daily. The initial dose for heart failure is 5 mg every 12 hours and the maintenance dose is 20 to 40 mg a day as a single dose or in two divided doses every 12 hours. Quinapril should be taken on an empty stomach because food reduces its absorption.
Which drugs or supplements interact with quinapril?
: The use of ACE inhibitors with potassium supplements, salt substitutes or diuretics (for example, spironolactone [Aldactone]) that increase potassium in the blood may lead to excessive potassium levels in the body. Potassium levels should be closely monitored whenever ace inhibitors are use in combination with these drugs.
Patients receiving diuretics or are dehydrated or have low blood sodium may experience excessive reduction in blood pressure when quinapril is started. Stopping the diuretic or increasing salt intake prior to taking quinapril may prevent this excessive reduction in blood pressure.
There have been reports that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors.
Combining quinapril or other ACE inhibitors with non-steroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) may occur when injectable gold (sodium aurothiomalate), used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors, including quinapril.
Quinapril should not be combined with aliskiren (Tekturna) because the combination of both drugs increases blockade of angiotensin leading to low blood pressure, increased blood potassium, and possible kidney damage.
Is quinapril safe to take if I'm pregnant or breastfeeding?
Angiotensin converting enzyme inhibitors, including quinapril, are very harmful to the fetus and, therefore, should not be used during pregnancy.
Quinapril is secreted into breast milk. Because of the risk of harm to the infant, quinapril should be used with caution during breastfeeding.
What else should I know about quinapril?
What preparations of quinapril are available?
Tablets: 5, 10, 20 and 40 mg
How should I keep quinapril stored?
Tablets and solutions should be stored at room temperature 15 C to 30 C (59 F to 86 F).
Reference: FDA Prescribing Information
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Quinapril (Accupril) is a medication prescribed to use in combination with other medications to treat high blood pressure and heart failure. Side effects, drug interactions, storage, dosage, and pregnancy safety information should be reviewed prior to taking any medication.
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Top quinapril Related ArticlesComplete List
ACE inhibitors, or angiotensin (generic name) converting enzyme inhibitors, is a class of drugs that interact with blood enzymes to enlarge or dilate blood vessels and reduce blood pressure. These drugs are used to:
- Control high blood pressure (hypertension)
- Treat of heart failure and ventricular dysfunction
- Prevent and treat of kidney disease in people with diabetes or hypertension.
These drugs also improve the survival rate of people who have survived heart attacks and they prevent early death of people from heart attacks, high blood pressure, and heart failure. Sometimes ACE inhibitors are combined with other drugs for treating a condition. Examples of ACE inhibitors include:
- benazepril (Lotensin)
- captopril (Capoten)
- enalapril (Vasotec)
- fosinopril (Monopril)
- ramipril (Altace)
Examples of the most common side effects of this class of drugs are:
- chest pain,
- and rash.
There are serious side effects of this drug like
- kidney failure,
- severe allergic reactions,
- and liver dysfunction or failure.
ACE inhibitors all are similar in the way they work; however, they differ in how the body eliminates doses of the drug. Drug interactions, dosage, and pregnancy and safety information should be reviewed prior to taking this medication.
Congestive Heart Failure (CHF) OverviewCongestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Diabetes MellitusDiabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Diabetes TreatmentThe major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with:
- and a diabetic diet.
- weight reduction,
- a diabetic diet,
- and exercise.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Febrile SeizuresFebrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include:
- losing consciousness,
- moving limbs on both sides of the body,
- lasts 1-2 minutes.
Heart AttackHeart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack can cause chest pain, heart failure, and electrical instability of the heart.
Heart Attack and Atherosclerosis Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back. Women experience the same symptoms as men; however, they also may experience:
- Extreme fatigue
- Pain in the upper abdomen
Leading a healthy lifestyle with a heart healthy low-fat diet, and exercise can help prevent heart disease and heart attack.
High Blood Pressure HypertensionHigh blood pressure is defined as a pressure of 140/90 mmHg or higher in the arteries. Genetic factors, high salt intake, and increased arterial stiffness cause high blood pressure. Dizziness, headache, nausea, and shortness of breath are just a few symptoms of high blood pressure. Untreated high blood pressure increases the risk of heart disease, kidney disease, atherosclerosis, eye damage, stroke, and increased risk of aneurysms. High blood pressure can be managed with weight loss, lifestyle changes, and medication.
High Blood Pressure Medication
High blood pressure (hypertension) medications include drugs from a variety of different drug classes and types.
- ACE inhibitors
- ARB (angiotensin receptor blockers)
- Beta blockers
- Calcium channel blockers (CCBs)
- Alpha-beta blockers
Clonidine (Catapres) and minoxidil also are drugs prescribed for the treatment of high blood pressure. Side effects, warnings and precautions, safety information, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
High Blood Pressure TreatmentHigh blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Hypertension PictureHigh blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. See a picture of Hypertension and learn more about the health topic.
Kidney FailureKidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss, dehydration, or medication. Some of the renal causes of kidney failure are:
- multiple myeloma, and
- acute glomerulonephritis.
- bladder obstruction,
- prostate problems,
- tumors, or
- kidney stones.
Lisinopril (Zestril, Prinivil, Qbrelis) is an ACE inhibitor prescribed for the treatment of:
- High blood pressure
- Heart failure
- Heart attack survival
- Preventing kidney failure due to high blood pressure
Side effects are, nasal congestion, anxiety, headaches, insomnia, drowsiness, and nausea. ACE inhibitors may cause a nonproductive cough that resolves once you stop taking the drug. Drug interactions include potassium supplements or derivatives of potassium, lithium (Eskalith, Lithobid), nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen), and symptoms of flushing; high blood pressure; nausea; and vomiting. Warnings and precautions, pregnancy information, and other safety information should be reviewed prior to taking any medication.
If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
ParathyroidectomyParathyroidectomy is the removal of one or more of the parathyroid glands to treat hyperparathyroidism. Risks of parathyroidectomy include:
- paralysis of the vocal cords,
- difficulty swallowing thin liquids,
- difficulty breathing,
- and drug reactions.
- damage to the recurrent laryngeal nerve,
- bleeding or hematoma,
- problems maintaining calcium levels in the blood,
- need for further and more aggressive surgery,
- need for a limited or total thyroidectomy,
- prolonged pain,
- impaired healing,
- and recurrence of the tumor.
Pregnancy Drug DangersTaking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some medications that have been found to cause no problems in pregnancy, however, medications such as Accutane for acne, should never be taken during pregnancy.