- Schizophrenia Slideshow Pictures
- Take the Schizophrenia Quiz
- Physical Symptoms of Depression Slideshow
- What is quetiapine (Seroquel, Seroquel XR)?
- What brand names are available for quetiapine?
- Is quetiapine (Seroquel, Seroquel XR) available as a generic drug?
- Do I need a prescription for quetiapine (Seroquel, Seroquel XR)?
- Why is quetiapine (Seroquel, Seroquel XR) prescribed to patients?
- What are the side effects of quetiapine (Seroquel, Seroquel XR)?
- What is the dosage for quetiapine (Seroquel, Seroquel XR)?
- Which drugs or supplements interact with quetiapine (Seroquel, Seroquel XR)?
- Is quetiapine (Seroquel, Seroquel XR) safe to use during pregnancy or while breastfeeding?
- What else should I know about quetiapine (Seroquel, Seroquel XR)?
Why is quetiapine (Seroquel, Seroquel XR) prescribed to patients?
What are the side effects of quetiapine (Seroquel, Seroquel XR)?
What are the side effects of quetiapine (Seroquel, Seroquel XR)?
- The most common side effects of Seroquel or Seroquel XR are
- Possible serious side effects include
- Other important side effects include a potentially fatal complex referred to as neuroleptic malignant syndrome (NMS), in which patients may have
- Quetiapine frequently causes tiredness (1 in 5 patients), especially during the first 3-5 days of treatment. Because of this tiredness, care should be exercised in any activity requiring mental alertness such as operating a motor vehicle or hazardous machinery.
- Less common side effects include seizures (1 in 125 patients) and hypothyroidism (1 in 250 patients).
Warning for people with high or low blood pressure and Seroquel or Seroquel XR
- Seroquel or Seroquel XR can cause orthostatic hypotension (a drop in blood pressure upon standing that can lead to dizziness or fainting) especially during the first 3-5 day period of treatment, when it is restarted after temporary discontinuation, and after an increase in the dose. The risk of orthostatic hypotension is about 1 in 100 (one of every hundred patients who take quetiapine).
- As with other antipsychotics, long-term use of quetiapine may lead to irreversible tardive dyskinesia, a neurologic disease which consists of involuntary movements of the jaw, lips, and tongue.
Warning for people with cataracts taking Seroquel or Seroquel XR
- In animals, quetiapine has been associated with the development of cataracts, and cataracts have been reported in patients using quetiapine for prolonged periods. Although it is not clear if quetiapine was responsible for the cataracts seen in humans, eye examinations by slit-lamp (to identify cataracts before they impair vision) are recommended at the beginning of treatment and every six months during treatment. If cataracts form, treatment should be discontinued.
Warning for people with high triglycerides or cholesterol taking Seroquel or Seroquel XR
- Quetiapine may increase blood concentrations of cholesterol and triglycerides by 11% and 17%, respectively.
Warning for people with diabetes taking quetiapine taking Seroquel or Seroquel XR
- There is an increased risk of hyperglycemia (high blood glucose) and diabetes-related events in patients taking atypical antipsychotics, including quetiapine. Patients should be tested during treatment for elevated blood-sugars. Additionally, persons with risk factors for diabetes, including obesity or a family history of diabetes, should have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetes. Any patient developing symptoms that suggest diabetes during treatment should be tested for diabetes.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
What is the dosage for quetiapine (Seroquel, Seroquel XR)?
- Immediate release quetiapine usually is taken two or three times daily.
- Extended release quetiapine is taken once daily.
- The dose usually is increased slowly over several days or weeks to achieve the desired effect.
- Quetiapine can be taken with or without food.
- The initial dose for bipolar disorder is 50 mg twice daily (100 mg/day) of immediate release quetiapine. The dose can be increased by 100 mg/day to a daily dose of 400 mg/day. Most patients respond to 400-800 mg/day. Doses greater than 800 mg/d have not been studied. The starting dose is 300 mg once daily and the target dose is 400-800 mg once daily when using extended release tablets.
- The initial dose for schizophrenia is 25 mg twice daily (50 mg/day) of immediate release tablets. The dose can be increased by 25-50 mg two or three times daily. The target dose is 300-400 mg/day in two or three doses. Patients respond to 150-750 mg/day, and doses greater than 800 mg/day have not been evaluated. The starting dose is 300 mg once daily and the target dose is 400-800 mg once daily when using extended release tablets.
- The dose range for treating major depression is 150-300 mg/day of extended release tablets. The starting does is 50 mg in the evening for 2 days increasing to 150 mg in the evening.
Which drugs or supplements interact with quetiapine (Seroquel, Seroquel XR)?
- Phenytoin (Dilantin) and thioridazine (Mellaril) markedly decrease the amount of Seroquel and Seroquel XR that is absorbed from the intestine and thereby reduces its effectiveness. Therefore, patients taking phenytoin or thioridazine may require higher doses of Seroquel and Seroquel XR.
- Seroquel and Seroquel XR can cause hypotension (low blood pressure) and therefore increase the blood pressure lowering effects of antihypertensive drugs and result in lower blood pressure.
- Seroquel and Seroquel XR can add to the sedating effects of other drugs that sedate. Such drugs include narcotic pain relievers (for example, oxycodone and acetaminophen [Percocet, Roxicet, Tylox, Endocet]), barbiturates, sedatives such as alprazolam [Xanax] and clonazepam [Klonopin], ethanol, and blood pressure drugs that can cause orthostatic hypotension, such as prazosin (Minipress) and terazosin (Hytrin).
- Seroquel and Seroquel XR is eliminated from the body by an enzyme in the liver called cytochrome P450 3A. There is a concern that drugs that strongly interfere with the enzyme may cause elevated and toxic levels of quetiapine, for example:
Mental Health Resources
Is quetiapine (Seroquel, Seroquel XR) safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of Seroquel and Seroquel XR in pregnant women. Studies in animals are inconsistent. Some studies suggest effects on the fetus and others show no effects. Seroquel and Seroquel XR should be used in pregnancy only if the physician feels that it is necessary and that the potential benefits justify the unknown risks.
- Seroquel and Seroquel XR is excreted in the milk of animals during lactation. Although it is not known if it is excreted in human milk, it is recommended that women taking Seroquel and Seroquel XR not breastfeed.
What else should I know about quetiapine (Seroquel, Seroquel XR)?
What preparations of quetiapine (Seroquel, Seroquel XR) are available?
- Tablets: 25, 50, 100, 200, 300 and 400 mg.
- Tablet (Extended Release): 50, 150, 200, 300 and 400 mg
How should I keep quetiapine (Seroquel, Seroquel XR) stored?
- Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
How does quetiapine (Seroquel, Seroquel XR) work?
- Although the mechanism of action of quetiapine is unknown, like other atypical anti-psychotics, it inhibits communication among nerves of the brain. It does this by blocking receptors on the nerves for several neurotransmitters, the chemicals that nerves use to communicate with each other. It is thought that its beneficial effect is due to blocking of the dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors.
When was quetiapine (Seroquel, Seroquel XR) approved by the FDA?
- The FDA approved quetiapine in September 1997.
- drowsiness, and
- weight gain.
- Possible serious and important side effects include
- priapism (prolonged erection),
- irregular pulse or blood pressure,
- rapid heart rate, and
- excessive sweating.
Multimedia: Slideshows, Images & Quizzes
Depression Quiz: Signs & Symptoms
Many people do not recognize the symptoms and warning signs of depression and depressive disorders in children and adults. With...
Schizophrenia Quiz: What is Schizophrenia?
Schizophrenia is a complex psychiatric disorder. Learn more about the challenges of mental illness with the Schizophrenia Quiz....
Bipolar Disorder: Symptoms, Testing for Bipolar Depression
Bipolar disorder (once called manic depression) causes extreme mood shifts and can be disorienting. Our experts define bipolar...
Depression Tips: Exercise, Diet, Stress Reduction, and More in Pictures
The right exercise, diet, and activities -- even playing with a pet --can help you recover from depression. Learn simple...
Schizophrenia: Symptoms, Types, Causes, Treatment
What is schizophrenia? Learn about schizophrenia symptoms, signs, and treatment. Read about schizophrenia types such as paranoid...
Physical Symptoms of Depression in Pictures
Depression can cause physical problems such as insomnia, chest pain, fatigue, headaches, and more. Learn the signs of depression...
Foods That Help Fight Depression
Food cannot prevent depression, but a healthy diet may boost your mood. Foods like salmon, carrots, Brazil nuts and even...
Related Disease Conditions
Anorexia is an eating disorder characterized by markedly reduced appetite or total aversion to food. Anorexia is a serious...
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one...
Schizophrenia is a disabling brain disorder that may cause hallucinations and delusions and affect a person's ability to...
Posttraumatic Stress Disorder
Post-traumatic stress disorder (PTSD), a psychiatric condition, can develop after any catastrophic life event. Symptoms include...
Bipolar disorder (or manic depression) is a mental illness characterized by depression, mania, and severe mood swings. Treatment...
Obsessive Compulsive Disorder (OCD)
Obsessive compulsive disorder (OCD) is an anxiety disorder that causes a person to suffer repeated obsessions and compulsions....
Postpartum depression is a form of depression that occurs within a year after delivery. It is thought that rapid hormone changes...
Mental health is an optimal way of thinking, relating to others, and feeling. All of the diagnosable mental disorders fall under...
Brief Psychotic Disorder
Brief psychotic disorder is a short-term mental illness that features psychotic symptoms. There are three forms of brief...
Psychotic disorders are a group of serious illnesses that affect the mind. Different types of psychotic disorders include...
Fragile X Syndrome
Fragile X syndrome is the most common inherited form of mental retardation. It's caused by a mutation on the X chromosome. People...
Bipolar Disorder in Children and Teens
Bipolar disorder, or manic-depressive illness, is a disorder that causes unusual and extreme mood changes. Symptoms of bipolar...
Schizotypal Personality Disorder
Schizotypal personality disorder is characterized by odd behaviors, feelings, perceptions, and ways of relating to others that...
Lewy Body Dementia (Dementia with Lewy Bodies)
Lewy body dementia (LBD or dementia with Lewy bodies) is one the most common causes of dementia. There are two types of LBD: 1)...
Bipolar Disorder vs. Schizophrenia
Bipolar disorder and schizophrenia are mental illnesses that share some risk factors and treatments. Symptoms of bipolar disorder...
Treatment & Diagnosis
- Doctor: Checklist to Take To Your Doctor's Appointment
- Altered Mental Status
- Panic Attack
- Bipolar Disorder
- Catatonia (Catatonic Behavior)
- Loss of Speech
- Poor Hygiene
- Unusual Behavior
- Inability to Regulate Emotions
- Abnormal Facial Expressions
- Lack of Facial Expressions
- Depression FAQs
- Schizophrenia FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Catherine Zeta-Jones: A Case of Bipolar II Disorder
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
- Antipsychotic Meds Pose Little Danger to Fetus, Study Finds
- 'Managing' Elderly Patients Without Powerful Antipsychotics
- Lithium Beats Newer Meds for Bipolar Disorder, Study Finds
- Antipsychotic Drugs Tied to Risk of Early Death in Parkinson's Patients
- Beware Safety Risks Posed by 'Off-Label' Drug Use
- Are Too Many Young Americans Getting Antipsychotics for ADHD?
- Certain Antipsychotic Meds Tied to Kidney Problems in Elderly
- Too Many Foster Kids With ADHD Treated With Antipsychotic Drugs: Study
- New Drug Shows Early Promise in Treating Parkinson's Psychosis
- Antipsychotic Meds Not That Helpful for Depression: Study
- Long-Term Use of Some Antipsychotics Not Warranted in Older Adults: Study
- Older Antipsychotics May Work as Well as Newer Ones: Review
- More Kids Taking Antipsychotics for ADHD: Study
- Prescription Meds Can Put on Unwanted Pounds
- Dementia: Some Antipsychotic Drugs Riskier Than Others
- Antipsychotics in Pregnancy Risky for Newborns
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.