Generic drug: pantoprazole sodium
Brand name: Protonix IV
What is Protonix IV (pantoprazole sodium), and how does it work?
Protonix IV (pantoprazole sodium) is a prescription medicine used to treat the symptoms of Erosive Esophagitis associated with GERD, short-term treatment of GERD, and Zollinger-Ellison Syndrome. Protonix IV may be used alone or with other medications.
It is not known if Protonix IV is safe and effective in children younger than 5 years of age.
What are the side effects of Protonix IV?
Protonix IV may cause serious side effects including:
- unusually fast, slow or irregular heartbeat,
- persistent muscle spasms,
- persistent diarrhea,
- abdominal pain or cramping,
- blood or mucus in your stool,
- swelling of the face, tongue and throat,
- severe dizziness,
- trouble breathing, and
- changes in the amount of urine
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Protonix IV include:
- redness, pain, or swelling at the injection site,
- abdominal pain,
- dizziness, and
- joint pain
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Protonix IV. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage for Protonix IV?
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to and during administration whenever solution and container permit.
- Parenteral routes of administration other than intravenous are not recommended.
- Protonix I.V. for Injection may be administered intravenously through a dedicated line or through a Y-site. The intravenous line should be flushed before and after administration of Protonix I.V. for Injection with either 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP. When administered through a Y-site, Protonix I.V. for Injection is compatible with the following solutions: 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP.
- Midazolam HCl has been shown to be incompatible with Y-site administration of Protonix I.V. for Injection. Protonix I.V. for Injection may not be compatible with products containing zinc. When Protonix I.V. for Injection is administered through a Y-site, immediately stop use if precipitation or discoloration occurs.
Gastroesophageal Reflux Disease Associated With A History Of Erosive Esophagitis
- The recommended adult dose is 40 mg pantoprazole given once daily by intravenous infusion for 7 to 10 days.
- Treatment with Protonix I.V. (pantoprazole sodium) for Injection should be discontinued as soon as the patient is able to receive treatment with Protonix Delayed-Release Tablets or Oral Suspension.
What drugs interact with Protonix IV?
Interference With Antiretroviral Therapy
- Concomitant use of atazanavir or nelfinavir with proton pump inhibitors is not recommended.
- Coadministration of atazanavir or nelfinavir with proton pump inhibitors is expected to substantially decrease atazanavir or nelfinavir plasma concentrations and may result in a loss of therapeutic effect and development of drug resistance.
- There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly.
- Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time.
- Concomitant administration of pantoprazole and clopidogrel in healthy subjects had no clinically important effect on exposure to the active metabolite of clopidogrel or clopidogrel-induced platelet inhibition.
- No dose adjustment of clopidogrel is necessary when administered with an approved dose of Protonix.
Drugs For Which Gastric Ph Can Affect Bioavailability
- Pantoprazole causes long-lasting inhibition of gastric acid secretion, therefore pantoprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (e.g., ketoconazole, ampicillin esters, iron salts, and digoxin).
False Positive Urine Tests For THC
- There have been reports of false positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving proton pump inhibitors including pantoprazole. An alternative confirmatory method should be considered to verify positive results.
- Case reports, published population pharmacokinetic studies, and retrospective analyses suggest that concomitant administration of PPIs and methotrexate (primarily at high dose; see methotrexate prescribing information) may elevate and prolong serum levels of methotrexate and/or its metabolite hydroxymethotrexate. However, no formal drug interaction studies of methotrexate with PPIs have been conducted.
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Is Protonix IV safe to use while pregnant or breastfeeding?
- There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
- Pantoprazole excretion in human milk has been detected in a study of a single nursing mother after a single 40 mg oral dose. The clinical relevance of this finding is not known.
- Many drugs which are excreted in human milk have a potential for serious adverse reactions in nursing infants.
- Based on the potential for tumorigenicity shown for pantoprazole in rodent carcinogenicity studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.
Protonix IV (pantoprazole sodium) is a prescription medicine called a Proton Pump Inhibitor (PPI) used to treat the symptoms of Erosive Esophagitis associated with GERD, short-term treatment of GERD, and Zollinger-Ellison Syndrome. Protonix IV may be used alone or with other medications. Side effects of Protonix IV include unusually fast, slow or irregular heartbeat, persistent muscle spasms, seizures, persistent diarrhea, abdominal pain or cramping, fever, blood or mucus in your stool, rash, itching, swelling of the face, tongue and throat, severe dizziness, trouble breathing, and changes in the amount of urine.
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Heartburn is a burning sensation experienced from acid reflux (GERD). Symptoms of heartburn include chest pain, burning in the throat, difficulty swallowing, the feeling of food sticking in the throat, and a burning feeling in the chest. Causes of heartburn include dietary habits, lifestyle habits, and medical causes. Treatments for heartburn include lifestyle changes, OTC medication,prescription medication, and surgery.
GERD (Acid Reflux, Heartburn)
GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the esophagus. The symptoms of uncomplicated GERD are: heartburn, regurgitation, and nausea. Effective treatment is available for most patients with GERD.
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Most people have experienced some sort of pain or discomfort following a large meal or a particular food that didn’t quite agree with their stomach. Acid reflux symptoms can happen without a specific underlying condition.
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Taking antacids is considered the quickest way to get rid of heartburn. These over-the-counter medications help neutralize stomach acid. They are one of the first recommended treatments. They may provide quick relief. However, antacid overuse can cause problems such as diarrhea or chronic kidney disease, especially if they contain aluminum and magnesium.
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Heartburn and acid reflux are not the same thing. Heartburn is actually a symptom of acid reflux. Heartburn gets its name because it feels like a burning sensation around the heart. Another symptom that occurs with heartburn is a bitter or sour taste in the mouth, usually when you eat or lye down. Heartburn affects more than 60 million people in the US at least once a month. Acid reflux, or GERD, occurs when stomach acid backs up into the esophagus, which irritates it. Heartburn is just one symptom of acid reflux. Other symptoms of acid reflux include: Belching Nausea after eating A feeling of fullness during or after eating Abdominal bloating Upset stomach Belching Wheezing Reflux laryngitis A tightness in the throat Problems swallowing Indigestion In some people, vomiting Causes of acid reflux and heartburn include: Being obese Slouching (poor posture) Medications like calcium channel blockers, theophylline, nitrates, and antihistamines Foods and drinks like caffeine, citrus fruits and vegetables, alcohol, and chocolate Pregnancy Diabetes Increase in stomach acid Eating a heavy meal Eating before bed The treatment for heartburn and acid reflux is to treat the underlying cause, for example, GERD, with over-the-counter (OTC) medicine, prescription medicine, natural remedies, and lifestyle changes like a eating a healthy, less fatty, spicy diet, not eating big meals, not eating before bed, and getting regular exercise to improve your posture.Sometimes a heart attack can mimic heartburn and acid reflux because they feel very similar. If you have symptoms of chest pain, tightness in the chest, heartburn, acid reflux, jaw, tooth, or head pain; shortness of breath, nausea, vomiting, sweating, discomfort in the upper middle of the abdomen, arm or upper back pain, or the general feeling of being ill, go to the nearest Emergency Department immediately because these are the symptoms of a heart attack.REFERENCES:American College of Gastroenterology. "Acid Reflux." 2017.<http://patients.gi.org/topics/acid-reflux/> familydoctor.org. "Heartburn." Updated: Mar 2014.<https://familydoctor.org/condition/heartburn/> National Library of Medicine; PubMed Health. "Heartburn and GERD: Treatment options for GERD." Updated: Nov 18, 2015.<https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072436/>
Reflux Laryngitis (Diet, Home Remedies, Medicine)
Reflux laryngitis is caused by acid refluxing back up through the esophagus and voice box. Reflux laryngitis causes irritation and inflammation of the lining of the esophagus, larynx, and throat; and can lead to symptoms, signs, and other problems like esophagitis, sinusitis, strictures, throat clearing, swallowing problems, asthma, chronic cough, and growths on the vocal cords. Typical symptoms of reflux laryngitis include heartburn, hoarseness, or a sensation of a foreign body in the throat. Reflux laryngitis can be treated with diet chanes, OTC medication, prescription medication, and lifestyle changes.
Heartburn During Pregnancy
Heartburn during pregnancy is quite common. During pregnancy the lower esophageal sphincter muscle becomes weakened , which likely occurs due to the effect of the high levels of the hormones estrogen and progesterone during pregnancy. Fortunately, this resolves after pregnancy. Management of heartburn during pregnancy are generally involves lifestyle changes and avoiding foods that promote heartburn, for example, don't smoke, avoid tight clothing, eat small, frequent meals, chew gum, or sip liquids.
How Does Acid Reflux Make You Feel? 10 Common Symptoms
Acid reflux can cause you to feel pain in your chest and a sour taste in your mouth. Find out more about acid reflux and 10 common symptoms that people with the condition often experience.
Heart Attack vs. Heartburn
Heartburn is a symptom of another disease or medical problem and can be described as a feeling of burning in the chest accompanied by symptoms of nausea, vomiting, or a sour taste or food stuck in the back of the throat. Heart attack occurs when an artery in the heart is completely blocked by a blood clot, which causes that portion of heart muscle to die. Heart attack also has symptoms of chest pain, nausea, and vomiting, however, other warning signs and symptoms of a heart attack are unusual weakness or fatigue, and persistent and/or increased severity of symptoms over a few minutes. Heart attack is a life threatening emergency. If you think you or someone you are with is having a heart attack, call 911 immediately for urgent medical treatment. It may save your life.
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