What's the Difference between Proton Pump Inhibitors and Zantac?
- Proton pump inhibitors (PPIs) and Zantac (ranitidine) reduce the production of acid and are used to prevent and treat of acid-related conditions including esophageal duodenal and stomach ulcers, NSAID-associated ulcers, ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.
- Some proton pump inhibitors are available over-the-counter (OTC) and some require a prescription. Zantac is available over-the-counter.
- Side effects of proton pump inhibitors and Zantac that are similar include constipation, diarrhea, headache, nausea, and vomiting.
- Side effects of proton pump inhibitors that are different from Zantac include abdominal pain gas, fever, and rash.
- Side effects of Zantac that are different from proton pump inhibitors include fatigue, insomnia, and muscle pain.
What are Proton Pump Inhibitors? What is Zantac?
Proton pump inhibitors (PPIs) are drugs that reduce the production of acid by blocking the enzyme in the wall of the stomach that produces acid that is responsible for most ulcers in the esophagus, stomach, and duodenum. Proton pump inhibitors are used to prevent and treat of acid-related conditions including esophageal duodenal and stomach ulcers, NSAID-associated ulcers, ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. PPIs also are used in combination with antibiotics for getting rid of the bacterium Helicobacter pylori, that together with acid, causes ulcers. Other proton pump inhibitors include omeprazole (Prilosec), lansoprazole (Prevacid), dexlansoprazole (Dexilent), rabeprazole (Aciphex), pantoprazole (Protonix), esomeprazole (Nexium), and omeprazole/sodium bicarbonate (Zegerid).
Zantac (ranitidine) blocks the production of acid by acid-producing cells in the stomach that helps to prevent and heal acid-induced inflammation and ulcers. Excessive stomach acid can damage the esophagus, stomach, and duodenum and lead to inflammation and ulceration. Zantac is a H2 (histamine-2) blocker. Other drugs in this class include cimetidine (Tagamet), nizatidine (Axid), and famotidine (Pepcid).
What Drugs Interact with Proton Pump Inhibitors vs. Zantac?
Proton pump inhibitors interact with few drugs.
- The absorption into the body of some drugs is affected by the presence of acid in the stomach, and because PPIs reduce acid in the stomach, they may affect the absorption of these drugs. Specifically, PPIs reduce the absorption and concentration in the blood of ketoconazole (Nizoral) and increase the absorption and concentration of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole and an increase in digoxin toxicity.
- Proton pump inhibitors can reduce the break-down of some drugs by the liver and lead to an increase in their concentration in the blood. Omeprazole (Prilosec) is more likely than the other PPIs to reduce the break-down of drugs by the liver. For example, omeprazole (Prilosec) may increase the concentration in the blood of diazepam (Valium), warfarin (Coumadin) and phenytoin (Dilantin).
- Omeprazole (Prilosec, Prilosec OTC) reduces the effect of clopidogrel (Plavix) by blocking the conversion of clopidogrel to its active form. This combination should be avoided.
Ranitidine, like other drugs that reduce stomach acid, may interfere with the absorption of drugs that require acid for adequate absorption. Examples include iron salts (for example iron sulphate), itraconazole (Sporanox), and ketoconazole (Nizoral, Extina, Xolegel, Kuric).
What Are the Side Effects of Proton Pump Inhibitors vs. Zantac?
The most common side effects of proton pump inhibitors are:
Nevertheless, proton pump inhibitors generally are well tolerated.
PPIs may increase the risk of Clostridium difficile infection of the colon. High doses and long-term use (1 year or longer) may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine. Prolonged use also reduces absorption of vitamin B12 (cyanocobalamin).
Long-term use of PPIs has also been associated with low levels of magnesium (hypomagnesemia). Analysis of patients taking PPIs for long periods of time showed an increased risk of heart attacks.
Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated.
Other serious side effects associate with PPIs include:
- Serious allergic reactions
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Reduced kidney function
- Reduced liver function
- Erythema multiforme
Minor side effects occur and these are:
Other important, but rare, side effects include:
Proton pump inhibitors (PPIs) reduce the production of acid and are used to prevent and treat of acid-related conditions including ulcers and gastroesophageal reflux disease (GERD). Zantac (ranitidine) also blocks the production of acid by acid-producing cells in the stomach, but is in a drug class called H2 (histamine) blockers.
Multimedia: Slideshows, Images & Quizzes
GERD Quiz: Test Your Digestive Diseases IQ
Who is at risk for developing GERD? Are you? Take this quiz to learn what GERD is, if you're at risk, and what you can do about...
Picture of Gastroesophageal Reflux (GERD)
The stomach contents regurgitate and back up (reflux) into the esophagus The food in the stomach is partially digested by...
Heartburn (Acid Reflux, GERD): Causes and Remedies
Heartburn is a symptom of acid reflux that causes chest pain when stomach acid backs up into the esophagus. Heartburn symptoms...
Related Disease Conditions
Gastroesophageal Reflux Disease (GERD)
Second Source article from Government...
Gastroesophageal Reflux Disease (GERD)
Second Source article from The Cleveland Clinic...
GERD (Acid Reflux, Heartburn)
GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the...
Peptic Ulcer (Stomach Ulcer)
Peptic or stomach ulcers are ulcers are an ulcer in the lining of the stomach, duodenum, or esophagus. Ulcer formation is related...
GERD and GER (Acid Reflux) in Infants and Children
GERD (gastroesophageal reflux disease) is the upward movement of stomach content, including acid, into the esophagus and...
Treatment & Diagnosis
- GERD Gastroesophageal Reflux Disease FAQs
- GERD Surgery - No Good?
- GERD: Questions To Ask Your Doctor About GERD (Heartburn)
- GERD Surgery Doesn't Prevent Cancer
- IBS, GERD, Hepatitis C: Doctors Dialogue
- GERD: Types of antacids for GERD?
- GERD: Safe GERD medications for pregnancy?
- GERD Acid reflux during pregnancy?
- GERD: Relief from GERD?
- GERD Symptoms improve with weight loss?
- Why is acid reflux GERD worse at night time?
- GERD Symptoms After Exercise?
- Bad breath from GERD?
- GERD Best treatment for Barrett Esophagus?
- GERD How long can you take Prilosec safely?
- GERD: Any substitute for Propulsid in treating GERD
- GERD: Use of Propulsid GERD
- What Is the Relationship Between GERD and Scleroderma?
- What Are Foods to Avoid With GERD?
Medications & Supplements
- ranitidine 25 mg effervescent - oral, Zantac
- famotidine - oral, Pepcid
- famotidine - injection, Pepcid
- esomeprazole delayed-release capsule - oral, Nexium
- ranitidine 75 mg - oral, Acid Reducer, Zantac 75
- cimetidine - oral, Tagamet
- lansoprazole delayed-release capsule - oral, Prevacid
- omeprazole delayed-release capsule - oral, Prilosec
- omeprazole/sodium bicarbonate - oral, Zegerid
- lansoprazole delayed-release suspension - oral, Prevacid
- omeprazole, omeprazole/sodium bicarbonate, Prilosec, Zegerid, Prilosec OTC, Zegerid OTC
- pantoprazole (Protonix)
- rabeprazole, Aciphex
- Prilosec (omeprazole) vs. Nexium (esomeprazole)
- Prilosec vs. Zantac
Quick GuideHeartburn: Foods to Eat, Foods to Avoid
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.