Progressive Supranuclear Palsy: Symptoms & Signs

Medically Reviewed on 9/10/2019

Progressive supranuclear palsy is a neurodegenerative disorder that gradually destroys cells in many areas of the brain, leading to serious and permanent neurologic symptoms. People often confuse it with Parkinson's disease because the symptoms may be similar.

Signs and symptoms of progressive supranuclear palsy include inability to walk, falling spells, changes in personality, forgetfulness, dizziness, stiffness, and problems with the control of gait and balance. There is damage in the area of the brain that coordinates eye movements, so most people have trouble controlling eye movements and maintaining eye contact during a conversation. Other symptoms can include dementia, depression, and loss of interest in socializing with friends and family.

Causes of progressive supranuclear palsy

The cause of progressive supranuclear palsy is unknown.

Other progressive supranuclear palsy symptoms and signs


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Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.