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- What is progesterone gel-vaginal, and how does it work (mechanism of action)?
- What brand names are available for progesterone gel-vaginal?
- Is progesterone gel-vaginal available as a generic drug?
- Do I need a prescription for progesterone gel-vaginal?
- What are the uses for progesterone gel-vaginal?
- What is the dosage for progesterone gel-vaginal?
- Which drugs or supplements interact with progesterone gel-vaginal?
- Is progesterone gel-vaginal safe to take if I'm pregnant or breastfeeding?
- What else should I know about progesterone gel-vaginal?
What is progesterone gel-vaginal, and how does it work (mechanism of action)?
- Progesterone is a female hormone and is the principal progestational hormone. Progestational hormones prepare the uterus (the womb) to receive and sustain the fertilized egg. Progesterone promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy.
- The FDA approved progesterone intravaginal gel in July 1997.
What are the uses for progesterone gel-vaginal?
- Intravaginal progesterone gel is used for supplementing or replacing progesterone in infertile women with progesterone deficiency who are receiving treatment utilizing assisted reproductive technology (ART).
- Progesterone intravaginal gel is also used for the treatment of secondary amenorrhea (absence of menses).
What is the dosage for progesterone gel-vaginal?
- For ART, the recommended dose of the 8% gel is 90 mg once daily in women who require progesterone supplementation, and 90 mg twice daily in women with partial or complete ovarian failure who require progesterone replacement. If pregnancy occurs, treatment may be continued until placental autonomy is achieved, up to 10-12 weeks.
- For the treatment of secondary amenorrhea, the 4% gel is administered vaginally every other day for six doses. Women who do not respond should receive the 8% gel.
Which drugs or supplements interact with progesterone gel-vaginal?
- There are no drug interactions listed for progesterone intravaginal gel.
Is progesterone gel-vaginal safe to take if I'm pregnant or breastfeeding?
- Progesterone intravaginal gel has been used to support embryo implantation and to maintain pregnancies as part of an ART treatment regimen. Progestins are secreted in breast milk.
What else should I know about progesterone gel-vaginal?
What preparations of progesterone gel-vaginal are available?
- Intravaginal gel: 4 and 8%;
- Intravaginal Insert: 100 mg
How should I keep progesterone gel-vaginal stored?
- Progesterone intravaginal gel should be stored at room temperature, 20 C to 25 C (68 F to 77 F)
Progesterone intravaginal gel (Crinone, Endometrin) is a prescription medication used for supplementing or replacing Progesterone in women who are infertile and are receiving assisted reproductive technology (ART). Side effects, drug interactions, warnings, dosing, and breastfeeding information should be reviewed prior to using this drug.
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