- A Visual Guide to PMS Slideshow
- Pelvic Inflammatory Disease (PID) Quiz: Test Your IQ
- Pelvic Pain Pictures Slideshow
- What is progesterone vaginal gel? What is progesterone gel used for?
- What are the side effects of progesterone gel?
- What is the dosage for progesterone gel?
- Which drugs or supplements interact with progesterone gel?
- Is progesterone gel safe to take if I'm pregnant or breastfeeding?
- What else should I know about progesterone gel?
What is progesterone vaginal gel? What is progesterone gel used for?
- Intravaginal progesterone gel is used for supplementing or replacing progesterone in infertile women with progesterone deficiency who are receiving treatment utilizing assisted reproductive technology (ART).
Progesterone intravaginal gel is also used for the treatment of secondary amenorrhea (absence of menses).
- Progesterone is a female hormone and is the principal progestational hormone. Progestational hormones prepare the uterus (the womb) to receive and sustain the fertilized egg. Progesterone promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy.
- The FDA approved progesterone intravaginal gel in July 1997.
What brand names are available for progesterone gel?
Is progesterone gel available as a generic drug?
Do I need a prescription for progesterone gel?
What are the side effects of progesterone gel?
Crinone (progesterone) gel is a bioadhesive vaginal gel contained in single-use, one-piece polyethylene vaginal applicators. Crinone is indicated as treatment for infertile women with progesterone deficiency and women with secondary amenorrhea. Crinone is available as a generic drug. Common side effects of Crinone include:
- stomach pain,
- tired feeling,
- stomach cramps,
- pain in your vaginal or rectal area,
- pain during intercourse,
- loss of interest in sex,
- breast swelling or tenderness,
- joint or muscle pain,
- increased night-time urination,
- vaginal discharge,
- vaginal burning, and
- vaginal itching.
Tell your doctor if you have serious side effects of Crinone including:
- sudden headache, numbness or weakness (especially on one side of the body):
- shortness of breath, or problems with vision, speech, or balance;
- chest pain or heavy feeling, pain spreading to the arm or shoulder;
- pain or swelling in one or both legs;
- stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- swelling in your hands, ankles, or feet;
- fever, chills, body aches, flu symptoms;
- a breast lump; or
- symptoms of depression (sleep problems, weakness, mood changes).
What is the dosage for progesterone gel?
- For ART, the recommended dose of the 8% gel is 90 mg once daily in women who require progesterone supplementation, and 90 mg twice daily in women with partial or complete ovarian failure who require progesterone replacement. If pregnancy occurs, treatment may be continued until placental autonomy is achieved, up to 10-12 weeks.
- For the treatment of secondary amenorrhea, the 4% gel is administered vaginally every other day for six doses. Women who do not respond should receive the 8% gel.
Which drugs or supplements interact with progesterone gel?
- There are no drug interactions listed for progesterone intravaginal gel.
Is progesterone gel safe to take if I'm pregnant or breastfeeding?
What else should I know about progesterone gel?
What preparations of progesterone gel are available?
- Intravaginal gel: 4 and 8%;
- Intravaginal Insert: 100 mg
How should I keep progesterone gel stored?
- Progesterone intravaginal gel should be stored at room temperature, 20 C to 25 C (68 F to 77 F)
Latest Women's Health News
Daily Health News
Progesterone intravaginal gel (Crinone, Endometrin) is a prescription medication used for supplementing or replacing Progesterone in women who are infertile and are receiving assisted reproductive technology (ART). Side effects, drug interactions, warnings, dosage, and breastfeeding information should be reviewed prior to using this drug.
Multimedia: Slideshows, Images & Quizzes
Boost Your Fertility: Ovulation Calculator, Pregnancy Planning and More
Boost fertility and increase your chances to conceive. Learn about ovulation calendars, diet, aging and other factors that can...
What Is Endometriosis? Symptoms, Causes, Treatment
What is endometriosis? Endometriosis is an abnormal growth of endometrial cells found in the uterus. Not to be confused with...
Fertility Options: Types, Treatments, and Costs
Learn about fertility options such as IVF (in vitro fertilization), acupuncture, and natural lifestyle choices. Read about...
Sex-Drive Killers: The Causes of Low Libido
Noticing a lack of intimacy with your partner? Here we explore how stress, lack of sleep, weight gain, depression and low T can...
What is the medical definition of infertility? Take the Infertility Quiz to learn the risks and treatment of infertility. Our...
Endometriosis Quiz: Test Your Medical IQ
Endometriosis is a common gynecological condition. Take this quiz to learn what happens when a woman has endometriosis as well as...
Related Disease Conditions
Bleeding During Pregnancy (First Trimester)
Bleeding during pregnancy is never normal. Causes of bleeding during the first trimester of a pregnancy may be caused by implantation bleeding, ectopic or tubal pregnancy, subchorionic hemorrhaging, infections, and miscarriage. Bleeding during the second and third trimesters of pregnancy can be caused by a variety of factors.
Early Pregnancy Symptoms and Signs
Pregnancy symptoms can vary from woman to woman, and not all women experience the same symptoms. When women do experience pregnancy symptoms they may include symptoms include missed menstrual period, mood changes, headaches, lower back pain, fatigue, nausea, breast tenderness, and heartburn. Signs and symptoms in late pregnancy include leg swelling and shortness of breath. Options for relief of pregnancy symptoms include exercise, diet, and other lifestyle changes.
Pregnancy (Week by Week, Trimesters)
Signs and symptoms of pregnancy vary by stage (trimester). The earliest pregnancy symptom is typically a missed period, but others include breast swelling and tenderness, nausea and sometimes vomiting, fatigue, and bloating. Second trimester symptoms include backache, weight gain, itching, and possible stretch marks. Third trimester symptoms are additional weight gain, heartburn, hemorrhoids, swelling of the ankles, fingers, and face, breast tenderness, and trouble sleeping. Eating a healthy diet, getting a moderate amount of exercise, also are recommended for a healthy pregnancy. Information about the week by week growth of your baby in the womb are provided.
Getting Pregnant (Tips for Trying to Conceive)
Trying to get conceive, or become pregnant can be challenging, frustrating, and an emotional rollercoaster for some couples. A couple can chart their progress, which may ultimately lead to a successful healthy pregnancy, or, when necessary, lead to discussions with a fertility specialist.
Pregnancy Planning (Tips)
Pregnancy planning is an important step in preparation for starting or expanding a family. Planning for a pregnancy includes taking prenatal vitamins, eating healthy for you and your baby, disease prevention (for both parents and baby) to prevent birth defects and infections, avoiding certain medications that may be harmful to your baby, how much weight gain is healthy exercise safety and pregnancy, travel during pregnancy.
Amenorrhea (including hypothalmic amenorrhea) is a condition in which there is an absence of menstrual periods in a woman. There are two types of amenorrhea: primary and secondary. Treatment of amenorrhea depends on the type. In primary, surgery may be an option and in secondary amenorrhea medication or lifestyle changes may be treatment options. We go over the definition of amenorrhea, causes, and treatment options for amenorrhea.
Infertility is the diminished ability to conceive a child. Infertility can be a problem with both men and women. Infertility in men can be caused by medical conditions, unhealthy habits, and toxins from the environment. Infertility in women can be caused by problems with ovarian function, the Fallopian tubes, or the physical characteristics of the uterus. Methods of conceiving for couples that cannot conceive include intrauterine inseminations (IUIs) or in vitro fertilization (IVF), specific drugs, assisted reproductive technology (ART), surgery, and gestational carrier.
Pregnancy and Drugs (Prescription and OTC)
Taking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some medications that have been found to cause no problems in pregnancy, however, medications such as Accutane for acne, should never be taken during pregnancy.
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.