- What is progesterone gel-vaginal, and how does it work (mechanism of action)?
- What brand names are available for progesterone gel-vaginal?
- Is progesterone gel-vaginal available as a generic drug?
- Do I need a prescription for progesterone gel-vaginal?
- What are the uses for progesterone gel-vaginal?
- What is the dosage for progesterone gel-vaginal?
- Which drugs or supplements interact with progesterone gel-vaginal?
- Is progesterone gel-vaginal safe to take if I'm pregnant or breastfeeding?
- What else should I know about progesterone gel-vaginal?
What is progesterone gel-vaginal, and how does it work (mechanism of action)?
- Progesterone is a female hormone and is the principal progestational hormone. Progestational hormones prepare the uterus (the womb) to receive and sustain the fertilized egg. Progesterone promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy.
- The FDA approved progesterone intravaginal gel in July 1997.
What are the uses for progesterone gel-vaginal?
- Intravaginal progesterone gel is used for supplementing or replacing progesterone in infertile women with progesterone deficiency who are receiving treatment utilizing assisted reproductive technology (ART).
- Progesterone intravaginal gel is also used for the treatment of secondary amenorrhea (absence of menses).
What is the dosage for progesterone gel-vaginal?
- For ART, the recommended dose of the 8% gel is 90 mg once daily in women who require progesterone supplementation, and 90 mg twice daily in women with partial or complete ovarian failure who require progesterone replacement. If pregnancy occurs, treatment may be continued until placental autonomy is achieved, up to 10-12 weeks.
- For the treatment of secondary amenorrhea, the 4% gel is administered vaginally every other day for six doses. Women who do not respond should receive the 8% gel.
Which drugs or supplements interact with progesterone gel-vaginal?
- There are no drug interactions listed for progesterone intravaginal gel.
Is progesterone gel-vaginal safe to take if I'm pregnant or breastfeeding?
- Progesterone intravaginal gel has been used to support embryo implantation and to maintain pregnancies as part of an ART treatment regimen. Progestins are secreted in breast milk.
What else should I know about progesterone gel-vaginal?
What preparations of progesterone gel-vaginal are available?
- Intravaginal gel: 4 and 8%;
- Intravaginal Insert: 100 mg
How should I keep progesterone gel-vaginal stored?
- Progesterone intravaginal gel should be stored at room temperature, 20 C to 25 C (68 F to 77 F)
Progesterone intravaginal gel (Crinone, Endometrin) is a prescription medication used for supplementing or replacing Progesterone in women who are infertile and are receiving assisted reproductive technology (ART). Side effects, drug interactions, warnings, dosing, and breastfeeding information should be reviewed prior to using this drug.
Multimedia: Slideshows, Images & Quizzes
Infertility Quiz: Test Your IQ of Infertility
What is the medical definition of infertility? Take the Infertility Quiz to learn the risks and treatment of infertility. Our...
Endometriosis Quiz: Test Your Medical IQ
Endometriosis is a common gynecological condition. Take this quiz to learn what happens when a woman has endometriosis as well as...
Sex-Drive Killers: The Causes of Low Libido
Noticing a lack of intimacy with your partner? Here we explore how stress, lack of sleep, weight gain, depression and low T can...
Boost Your Fertility: Ovulation Calculator, Pregnancy Planning and More
Boost fertility and increase your chances to conceive. Learn about ovulation calendars, diet, aging and other factors that can...
Infertility: Types, Treatments, and Costs
Learn about infertility symptoms and types of treatment such as IVF, acupuncture, and natural methods to get pregnant. Read about...
Endometriosis Symptoms, Stages, Treatment
What is endometriosis? Endometriosis is an abnormal growth of endometrial cells like those found in a woman's uterus. Learn about...
Related Disease Conditions
Pregnancy Planning (Tips)
Pregnancy planning is an important step in preparation for starting or expanding a family. Planning for a pregnancy includes...
Pregnancy and Drugs (Prescription and OTC)
Taking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some...
Pregnancy (Week By Week, Trimesters)
Signs and symptoms of pregnancy vary by stage (trimester). The earliest pregnancy symptom is typically a missed period, but...
Infertility is the diminished ability to conceive a child. Infertility can be a problem with both men and women. Infertility in...
Getting Pregnant (Tips for Trying to Conceive)
Trying to get conceive, or become pregnant can be challenging, frustrating, and an emotional rollercoaster for some couples. A...
Early Pregnancy Symptoms and Signs
Pregnancy symptoms can vary from woman to woman, and not all women experience the same symptoms. When women do experience...
Amenorrhea (including hypothalmic amenorrhea) is a condition in which there is an absence of menstrual periods in a woman. There...
Bleeding During Pregnancy (First Trimester)
Bleeding during pregnancy is never normal. Causes of bleeding during the first trimester of a pregnancy may be caused by...
Treatment & Diagnosis
Prevention & Wellness
Women's Conditions Resources
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.