progesterone

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is progesterone-oral, and how does it work (mechanism of action)?

Progesterone is a man-made medication derived from a plant source and is identical to the female hormone, progesterone produced in the ovaries. It promotes the development of the mammary glands, causes changes in the endometrium, which lines the uterus, relaxes uterine smooth muscles, blocks ovulation within the ovaries, and maintains pregnancy. Progesterone was approved in May, 1998.

What brand names are available for progesterone-oral?

Prometrium

Is progesterone-oral available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for progesterone-oral?

Yes

What are the side effects of progesterone-oral?

Side effects of progesterone are headache, dizziness, fatigue, abdominal pain, nausea, breast tenderness, joint pain, depression, mood swings, and hot flashes.

Progesterone also isassociated with cardiovascular disorders, breast cancer, and possibly dementia in postmenopausal women.

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What is the dosage for progesterone-oral?

Prevention of Endometrial Hyperplasia: 200 mg by mouth once daily at bedtime for 12 consecutive days per 28 day cycle. Treatment of Secondary Amenorrhea: 400 mg by mouth once daily at bedtime for 10 days.

Which drugs or supplements interact with progesterone-oral?

Progesterone should be used with caution with ketoconazole (Nizoral), clarithromycin (Biaxin), and erythromycin (Ery-Tab) because they slow the breakdown of progesterone and increase its levels in the body.

Is progesterone-oral safe to take if I'm pregnant or breastfeeding?

Progesterone should not be used during pregnancy.

Progesterone may be found in trace amounts in breast milk in women taking progesterone capsules.

What else should I know about progesterone-oral?

What preparations of progesterone-oral are available?

Capsules: 100 and 200 mg

How should I keep progesterone-oral stored?

Progesterone capsules should be stored between 20 C to 25 C (68 F to 77 F) and should be protected from excessive moisture.

REFERENCE: FDA Prescribing Information
Progesterone – Medscape

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Women's Health: Nutrition and Health Care Reform

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Reviewed on 10/7/2014
References
REFERENCE: FDA Prescribing Information
Progesterone – Medscape

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