Progeria: Symptoms & Signs

Medically Reviewed on 9/1/2020

Progeria is a rare genetic condition that causes children to age prematurely along with dwarfism. Children with progeria appear normal at birth but shortly afterward experience decreased growth.

Signs and symptoms include

  • slowed growth, with below-average height and weight,
  • narrowed face,
  • small lower jaw,
  • thin lips,
  • beaked nose, and
  • head size disproportionately large for the face.

Other associated signs and symptoms can include

  • prominent eyes and incomplete closure of the eyelids;
  • hair loss, including eyelashes and eyebrows;
  • thinning, spotty, wrinkled skin;
  • visible veins; and a
  • high-pitched voice.

Cause of progeria

A mutation in the gene that codes for a protein known as lamin-A causes progeria. Instead of being inherited from the parents, the genetic mutation occurs as a new mutation in every affected person.

Other progeria symptoms and signs

  • Beaked Nose
  • Hair Loss, Including Eyelashes and Eyebrows
  • Head Size Disproportionately Large for the Face
  • High-Pitched Voice
  • Narrowed Face
  • Prominent Eyes and Incomplete Closure of the Eyelids
  • Slowed Growth, With Below-Average Height and Weight
  • Small Lower Jaw
  • Thin Lips
  • Thinning, Spotty, and Wrinkled Skin
  • Visible Veins

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References
Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.