- What is probenecid, and how does it work (mechanism of action)?
- Is probenecid available as a generic drug?
- Do I need a prescription for probenecid?
- What are the uses for probenecid?
- What are the side effects of probenecid?
- What is the dosage for probenecid?
- Which drugs or supplements interact with probenecid?
- Is probenecid safe to take if I'm pregnant or breastfeeding?
- What else should I know about probenecid?
What is probenecid, and how does it work (mechanism of action)?
Probenecid is an oral drug used for reducing blood uric acid levels in patients with hyperuricemia (high uric acid) and/or. High uric acid can cause attacks of gout and kidney stones. Probenecid prevents attacks of gout by reducing uric acid levels in the blood. It does this by preventing the reabsorption of uric acid by the kidney and increasing its excretion from the body in the urine. Probenecid also blocks excretion by the kidney of penicillin and related antibiotics and is used for increasing the levels of the antibiotics in the blood and increasing their effectiveness when treating infections.
What are the uses for probenecid?
Probenecid is used for the treatment of hyperuricemia associated with gout. It also is used for increasing blood levels of penicillin-type antibiotics (for example, ampicillin and amoxicillin) when treating gonorrhea.
What are the side effects of probenecid?
Common side effects of probenecid include:
Probenecid may cause a flare of gout and kidney stones, and it is not started during an acute attack of gout. Serious but rare side effects include reduced red blood cell counts (anemia), liver damage and severe allergic reactions.
Quick GuideGout Attack Symptoms, Causes, Treatment, and Diet
What is the dosage for probenecid?
The usual adult dose for hyperuricemia is 500 mg twice daily and the maximum dose is 2 grams daily. When combined with penicillin type antibiotics to treat infections, the usual dose is 500 mg 4 times daily. Patients should drink plenty of water in order to prevent formation of kidney stones and take probenecid with food or antacid to reduce stomach upset.
Which drugs or supplements interact with probenecid?
Probenecid blocks excretion of some drugs by the kidney and, therefore, may increase blood levels and side effects of methotrexate (Rheumatrex, Trexall) and nonsteroidal antiinflammatory drugs (NSAIDs), for example, ibuprofen (Advil), naproxen (Aleve), indomethacin (Indocin), ketorolac (Toradol) and others. Aspirin may reduce the action of probenecid through unknown mechanisms.
Is probenecid safe to take if I'm pregnant or breastfeeding?
Probenecid has not been adequately studied in pregnant women.
Probenecid has not been adequately studied in nursing mothers.
What else should I know about probenecid?
What preparations of probenecid are available?
Tablets: 0.5 g
How should I keep probenecid stored?
Probenecid should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Reference: FDA Prescribing Information
Probenecid (former brand name Benemid) is a drug prescribed for the treatment of gout and kidney stones. Probenecid is also used to increase the blood levels of penicillin type antibiotics used for the treatment of gonorrhea. Side effects, warnings and precautions, and drug interactions should be reviewed prior to taking this medicaiton.
Multimedia: Slideshows, Images & Quizzes
Gout Quiz: What is Gout? Is There a Gout Diet?
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Amoxicillin (Amoxil, Moxatag, Larotid) is an antibiotic that belongs to a class of antibiotics called penicillins. Common infections that amoxicillin is used to treat include middle ear infections, tonsillitis, laryngitis, bronchitis, pneumonia, skin, gonorrhea, and urinary tract infections.
Common side effects of amoxicillin include nausea, itching, vomiting, confusion, abdominal pain, and easy bruising.
Drug interactions, dosing, storage, and pregnancy and breastfeeding safety should be reviewed prior to taking penicillins.
Dispermox, Trimox, Wymox, Utimox, and Polymox are discontinued brands and are no longer available in the US.
amoxicillin and clavulanic acid
Amoxicillin and clavulanic acid (Augmentin Amoclan, Augmentin XR, Augmentin ES-600) is a penicillin type antibiotic prescribed for the treatment of middle ear infections, sore throat, sinus infection, bronchitis, pneumonia, and urinary tract infections. Side effects, drug interactions, patient safety information, and pregnancy efficacy should be reviewed prior to taking any medication.
ampicillinAmpicillin is an antibiotic used to treat infections caused by:
- H. influenzae,
- N. gonorrhoea,
- E. coli,
- streptococci and
- certain strains of staphylococci.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Gonorrhea In WomenGonorrhea is a bacterial infection transmitted during sexual contact. In women, symptoms include a yellow vaginal discharge, burning or frequent urination, and redness, swelling, burning and itching of the vaginal area. Gonorrhea can be treated with injectable (penicillin) or oral medications.
Gout (Gouty Arthritis)Buildup of uric acid crystals in a joint causes gouty arthritis. Symptoms and signs include joint pain, swelling, heat, and redness, typically of a single joint. Gout may be treated with diet and lifestyle changes, as well as medication.
Gout PictureCondition characterized by abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation (arthritis), deposits of hard lumps of uric acid in and around the joints, and decreased kidney function and kidney stones. See a picture of Gout and learn more about the health topic.
Take the Gout QuizLearn what causes those painful crystals to form during a gout flare. Take the Gout Quiz to learn all about this painful arthritic condition.
Kidney StonesKidney stones are solid masses of crystalline material that form in the kidneys. Symptoms of kidney stones can include pain, nausea, vomiting, and even fever and chills. Kidney stones are diagnosed via CT scans and specialized X-rays. Treatment of kidney stones involves drinking lots of fluids and taking over-the-counter pain medications to medical intervention including prescription medications, lithotripsy, and sometimes even surgery.
Sexually Transmitted Diseases (STDs In Women)
Sexually transmitted diseases, or STDs, are infections that are transmitted during any type of sexual exposure, including intercourse (vaginal or anal), oral sex, and the sharing of sexual devices, such as vibrators. Women can contract all of the STDs, but may have no symptoms, or have different symptoms than men do. Common STDs in women are:
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Treatment for STDs depends upon the type.
Sexually Transmitted Diseases and Pregnancy (STDs)When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.
STDs in Men Overview
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like
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Common STDs in men include:
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- Hepatitis C
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- Genital herpes
Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely.
sulfinpyrazoneSulfinpyrazone - (Anturane - discontinued in the US) is a drug prescribed to reduce elevated blood uric acid levels with gout to prevent recurrent attacks of arthritis. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.