- What is probenecid, and how does it work (mechanism of action)?
- What are the uses for probenecid?
- What are the side effects of probenecid?
- What is the dosage for probenecid?
- Which drugs or supplements interact with probenecid?
- Is probenecid safe to take if I'm pregnant or breastfeeding?
- What else should I know about probenecid?
What is probenecid, and how does it work (mechanism of action)?
Probenecid is an oral drug used for reducing blood uric acid levels in patients with hyperuricemia (high uric acid) and/or. High uric acid can cause attacks of gout and kidney stones. Probenecid prevents attacks of gout by reducing uric acid levels in the blood. It does this by preventing the reabsorption of uric acid by the kidney and increasing its excretion from the body in the urine. Probenecid also blocks excretion by the kidney of penicillin and related antibiotics and is used for increasing the levels of the antibiotics in the blood and increasing their effectiveness when treating infections.
Is probenecid available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for probenecid?
What are the side effects of probenecid?
Common side effects of probenecid include:
Probenecid may cause a flare of gout and kidney stones, and it is not started during an acute attack of gout. Serious but rare side effects include reduced red blood cell counts (anemia), liver damage and severe allergic reactions.
What is the dosage for probenecid?
The usual adult dose for hyperuricemia is 500 mg twice daily and the maximum dose is 2 grams daily. When combined with penicillin type antibiotics to treat infections, the usual dose is 500 mg 4 times daily. Patients should drink plenty of water in order to prevent formation of kidney stones and take probenecid with food or antacid to reduce stomach upset.
Which drugs or supplements interact with probenecid?
Probenecid blocks excretion of some drugs by the kidney and, therefore, may increase blood levels and side effects of methotrexate (Rheumatrex, Trexall) and nonsteroidal antiinflammatory drugs (NSAIDs), for example, ibuprofen (Advil), naproxen (Aleve), indomethacin (Indocin), ketorolac (Toradol) and others. Aspirin may reduce the action of probenecid through unknown mechanisms.
Is probenecid safe to take if I'm pregnant or breastfeeding?
Probenecid has not been adequately studied in pregnant women.
Probenecid has not been adequately studied in nursing mothers.
What else should I know about probenecid?
What preparations of probenecid are available?
Tablets: 0.5 g
How should I keep probenecid stored?
Probenecid should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
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Probenecid (former brand name Benemid) is a drug prescribed for the treatment of gout and kidney stones. Probenecid is also used to increase the blood levels of penicillin-type antibiotics used for the treatment of gonorrhea. Review side effects, dosage, warnings and precautions, and drug interactions prior to taking this medication.
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Condition characterized by abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation...
Related Disease Conditions
Buildup of uric acid crystals in a joint causes gouty arthritis. Symptoms and signs include joint pain, swelling, heat, and redness, typically of a single joint. Gout may be treated with diet and lifestyle changes, as well as medication.
Kidney Stones (nephrolithiasis)
Kidney stones are solid masses of crystalline material that form in the kidneys. Symptoms of kidney stones can include pain, nausea, vomiting, and even fever and chills. Kidney stones are diagnosed via CT scans and specialized X-rays. Treatment of kidney stones involves drinking lots of fluids and taking over-the-counter pain medications to medical intervention including prescription medications, lithotripsy, and sometimes even surgery.
Sexually Transmitted Diseases in Women (STDs)
Sexually transmitted diseases (STDs) are among the most common infectious diseases in the United States. STDs can be spread through any type of sexual activity involving the sex organs, the anus or mouth, or through contact with blood during sexual activity. Examples of STDs include, chancroid, chlamydia, gonorrhea, granuloma inguinale, lymphogranuloma venereum, syphilis, genital herpes, genital warts, trichomoniasis, pubic lice (crabs), and scabies. Treatment is generally with antibiotics; however, some STDs that go untreated can lead to death.
Gonorrhea In Women
Gonorrhea is a bacterial infection transmitted during sexual contact. In women, symptoms include a yellow vaginal discharge, burning or frequent urination, and redness, swelling, burning and itching of the vaginal area. Gonorrhea can be treated with injectable (penicillin) or oral medications.
STDs in Men
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like genital burning, itching, sores, rashes, or discharge. Common infections that are sexually transmitted in men include gonorrhea, chlamydia, syphilis, hepatitis C and B, genital warts, human papillomavirus (HPV), and genital herpes. Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely.
Sexually Transmitted Diseases and Pregnancy (STDs)
When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.