Primary sclerosing cholangitis (PSC) is a disease of the liver in which the bile ducts become inflamed, narrow, and prevent bile from flowing properly. As the bile ducts become inflamed and narrow, bile begins to back up in the liver, causing liver cells to become inflamed. Over time, this leads to decreased blood flow within the liver, increasing the pressure in the portal vein. This eventually causes a condition known as portal hypertension.
In the early stages, PSC does not cause symptoms. As it develops, the signs and symptoms of primary sclerosing cholangitis can include
- pain in the upper right part of the abdomen,
- night sweats,
- an enlarged liver,
- enlarged spleen,
- weight loss, and
- yellowing of the eyes and skin (jaundice).
Cause of primary sclerosing cholangitis (PSC)
Doctors do not understand the exact cause of PSC.
Other primary sclerosing cholangitis symptoms and signs
- Enlarged Liver
- Enlarged Spleen
- Jaundice (Yellowing of the Eyes and Skin)
- Night Sweats
- Pain in the Upper Right Part of the Abdomen
- Weight Loss
Main Article on Primary Sclerosing Cholangitis Symptoms and Signs
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