Primary Ovarian Insufficiency: Symptoms & Signs

Medically Reviewed on 9/27/2022

Primary ovarian insufficiency is a condition in which the ovaries stop producing eggs and female hormones before the age of 40.

Signs and symptoms of primary ovarian insufficiency include

Other associated symptoms can include a decrease in sexual desire and vaginal dryness that may make sexual intercourse uncomfortable.

Causes of Primary Ovarian Insufficiency

There are a number of potential causes of the condition, but some cases may occur without a known cause. Known causes of primary ovarian insufficiency can include genetic conditions, chemotherapy or radiation therapy for cancer, autoimmune disease, or exposure to toxins or poisons.

Other primary ovarian insufficiency symptoms and signs


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.