- Fibromyalgia Overview Slideshow
- Take the Fibromyalgia Quiz
- Fibromyalgia: 12 Tips for Coping Slideshow
- What is Lyrica (pregabalin)?
- Why is Lyrica (pregabalin) prescribed to patients?
- What are the side effects of Lyrica (pregabalin)?
- What is the dosage for Lyrica (pregabalin)?
- Which drugs or supplements interact with Lyrica (pregabalin)?
- Is Lyrica (pregabalin) safe to use during pregnancy or while breastfeeding?
- What else should I know about Lyrica (pregabalin)?
What is Lyrica (pregabalin)?
Lyrica (pregabalin) is an oral medication that is chemically related to gabapentin (Gralise, Neurontin). It is used for treating pain caused by neurologic diseases such as postherpetic neuralgia as well as seizures. It also is used for treating fibromyalgia.
Is Lyrica (pregabalin) available as a generic drug?
Do I need a prescription for Lyrica (pregabalin)?
What are the side effects of Lyrica (pregabalin)?
SIDE EFFECTS WARNING:
- Antiepileptic medications have been associated with increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
The most common side effects of Lyrica are
- dry mouth (xerostomia),
- edema (accumulation of fluid),
- blurred vision,
- double vision (diplopia),
- weight gain,
- fatigue (tiredness),
- abnormal gait (ataxia),
- tremor, and
- difficulty concentrating.
Other side effects include
- increased appetite,
- myoclonus (sudden, involuntary jerking of a muscle or muscle groups),
- heart failure,
- low blood pressure,
- reduced blood platelet counts, and
- increased blood creatinine kinase levels.
Increased creatinine kinase can be a sign of muscle injury, and in clinical trials three patients experienced rhabdomyolysis (severe muscle injury). Therefore, patients should report unexplained muscle pain, tenderness or weakness to their doctors, especially if associated with fever and malaise (reduced well-being). Lyrica has rarely been associated with angioedema (swelling of the face, tongue, lips, and gums, throat and larynx).
What is the dosage for Lyrica (pregabalin)?
- Lyrica may be taken with or without food.
- Treating diabetic peripheral neuropathy: The initial dose for neuropathic pain associated with diabetic peripheral neuropathy is 50 mg three times a day (150 mg/day). The dose may be increased to a maximum dose of 100 mg 3 times daily (300 mg/day) after one week.
- Treating postherpetic neuralgia: The recommended dose for postherpetic neuralgia is 75-150 mg twice daily or 50-100 mg three times daily. Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day). The dose may be increased to 100 mg 3 times daily (300 mg/day) after one week. If pain relief is inadequate after 2-4 weeks of treatment at 300 mg/day, the dose may be increased to 300 mg twice daily or 200 mg three times daily. Doses greater than 300 mg cause more side effects.
- Treating neuropathic pain associated with spinal cord injury: The dose for treating neuropathic pain associated with spinal cord injury is 150 to 600 mg daily. Begin dosing at 75 mg two times a day an increase to 150 mg two times daily after one week if response is inadequate. May increase to 300 mg twice daily if response is inadequate after 2 to 3 weeks.
- Treating seizures: The recommended dose for treating seizures is 150-600 mg/day divided into 2 or 3 doses, starting at 150 mg daily and increasing based on response and tolerability. The maximum dose is 600 mg/day.
- Treating fibromyalgia: Fibromyalgia is treated with 300-450 mg/day in 2 or 3 divided doses.
Which drugs or supplements interact with Lyrica (pregabalin)?
- Alcohol and drugs that cause sedation may increase the sedative effects of pregabalin.
- Pioglitazone (Actos) and rosiglitazone (Avandia) cause weight gain, fluid retention, and possibly heart failure. Therefore, combining pregabalin with these drugs may increase the occurrence of weight gain and fluid retention.
Latest Chronic Pain News
Daily Health News
Is Lyrica (pregabalin) safe to use during pregnancy or while breastfeeding?
What else should I know about Lyrica (pregabalin)?
What preparations of Lyrica (pregabalin) are available?
- Capsules: 25, 50, 75, 100, 150, 200, 225, and 300 mg.
- Oral Solution: 20 mg/ml
How should I keep Lyrica (pregabalin) stored?
- Pregabalin should be stored at room temperature, from 15 C to 30 C (59 F to 86 F).
How does Lyrica (pregabalin) work?
- The mechanism of action of pregabalin is unknown. Pregabalin binds to calcium channels on nerves and may modify the release of neurotransmitters (chemicals that nerves use to communicate with each other). Reducing communication between nerves may contribute to pregabalin's effect on pain and seizures.
When was Lyrica (pregabalin) approved by the FDA?
- The FDA approved pregabalin in December 2004.
Lyrica (pregabalin) is a drug prescribed for the treatment of neuropathic pain associated with diabetic peripheral neuropathy or post neuralgia; partial onset seizures in adults; and fibromyalgia. Side effects include
- blurred vision,
- double vision (diplopia),
- weight gain,
- fatigue (tiredness),
- increased appetite,
- nausea, and
- intestinal gas.
Multimedia: Slideshows, Images & Quizzes
Diabetic Neuropathy Quiz: Test Your Medical IQ
Diabetic neuropathy is serious. Take this quiz to get the facts.
Epilepsy & Seizures Quiz: What Causes Seizures?
Do you know the difference between seizures and epilepsy? What are the types of seizures? Take the Epilepsy & Seizures Quiz to...
Fibromyalgia Quiz: What Is Fibromyalgia?
Fibromyalgia could be the reason for your constant, deep bodily pain. Learn more about this painful condition with the...
Chronic Fatigue Syndrome Quiz: Symptoms & Treatment
Exhausted all the time? Maybe it's not all in the mind. Take the Chronic Fatigue Syndrome (CFS) Quiz to learn more about tricky...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Picture of Fibromyalgia
A syndrome characterized by chronic pain, stiffness, and tenderness of muscles, tendons, and joints without detectable...
Fibromyalgia Symptoms, Diagnosis & Treatment
What is fibromyalgia? Fibromyalgia is a chronic condition that causes pain and stiffness of the tendons, muscles, and joints....
Fibromyalgia Pain Relief: Stretching and Strength Exercises
Living with fibromyalgia is painful. By making simple exercise modifications, you can boost your energy, decrease pain and...
Nerve Pain: Symptoms, Causes, and Treatment Options
Learn about nerve pain symptoms, causes, and treatment options. Discover medications, treatments, and natural remedies that can...
Fibromyalgia Treatments and Tips to Ease Pain and Other Symptoms
What is fibromyalgia? Learn about fibromyalgia symptoms such as trigger points (also called tender points), learn what causes...
Chronic Pain Syndrome: Treatment and Management for CPS
What is chronic pain syndrome (CPS)? See causes, symptoms and treatment options including medications. Learn about pain...
Diabetic Peripheral Neuropathy: Improve Diabetes Nerve Pain
Read about diabetic peripheral neuropathy and exercises to manage nerve pain. Learn how to cope with the symptoms of diabetic...
How Does Acupuncture Work? Benefits, Needles, Definition
What is acupuncture? How does acupuncture work? Does acupuncture hurt? Learn various acupuncture points, the definition of...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive pain management...
Related Disease Conditions
Fibromyalgia is a chronic pain condition characterized by symptoms such as fatigue, sleep disturbances, and tender points. Stress reduction, exercise, and medication are the standard treatments for fibromyalgia.
Peripheral neuropathy is a problem with the functioning of the nerves outside of the spinal cord. Symptoms may include numbness, weakness, burning pain (especially at night), and loss of reflexes. Possible causes may include carpel tunnel syndrome, shingles, vitamin or nutritional deficiencies, and illnesses like diabetes, syphilis, AIDS, and kidney failure. Peripheral neuropathy is diagnosed with exams and tests. Treatment for the condition depends on the cause. Usually, the prognosis for peripheral neuropathy is good if the cause can be successfully treated or prevented.
Epilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are many causes of epilepsy. Treatment of epilepsy (seizures) depends upon the cause and type of seizures experienced.
Shingles, or herpes zoster, is a painful rash caused by the varicella zoster virus. Other shingles symptoms include headache, fever, nausea, and body aches. Treatment focuses on pain management and shortening the duration of the illness with antiviral medications.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
Neuropathic pain is a chronic condition that leads to ongoing pain symptoms. Patients can be predisposed to developing neuropathic pain who have conditions such as: diabetes, cancer, stroke, HIV, vitamin deficiencies, shingles, and multiple sclerosis. Patient history and nerve testing are used to diagnose neuropathic pain. Antidepressants, antiseizure medications, and other types of medications are used to treat neuropathic pain. Many people with neuropathic pain are able to attain some level of relief.
Diabetic Neuropathy (Symptoms, Causes, Diagnosis, Treatment)
Diabetic neuropathy a condition in which nerve damage has occurred as a complication of diabetes. The pain from the nerve damage can be severe with tingling or numbness in the part of the body affected. Diabetic neuropathy can occur anywhere in the body. Diabetic neuropathy can cause symptoms like intense pain, numbness, burning, or tingling in the part of the body affected by the condition. There are four types of neuropathy include peripheral, autonomic, proximal and focal. Natural therapies and medications may help relieve the pain and other symptoms of diabetic neuropathy.
Seizures Symptoms and Types
Seizures are divided into two categories: generalized and partial. Generalized seizures are produced by electrical impulses from throughout the brain, while partial seizures are produced by electrical impulses in a small part of the brain. Seizure symptoms include unconsciousness, convulsions, and muscle rigidity.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Head and Neck Cancer
Head and neck cancer is cancer of the oral cavity, salivary glands, paranasal sinuses and nasal cavity, pharynx, larynx, or lymph nodes in the upper part of the neck. These cancers account for 3% to 5% of cancers in the U.S. Tobacco and alcohol use are important risk factors. Treatment may involve surgery, radiation therapy, and/or chemotherapy.
Lumbar Spinal Stenosis
Lumbar stenosis can be caused by degenerative arthritis (the most common cause), tumor, infection, or metabolic disorders (Paget's disease of the bone). Symptoms include low back pain, weakness, pain, numbness, and loss of sensation in the legs. Other conditions may cause similar symptoms of lumbar stenosis, including diabetic neuropathy, claudication, and peripheral vascular disease. Lumbar stenosis may be treated with medication or surgery.
Pinched Nerve (Symptoms, Locations, Causes, Treatment, and Prognosis)
A pinched nerve causes pain, numbness, or tingling in the affected area due to pressure on a nerve. Carpal tunnel and sciatica are two examples of conditions caused by a pinched nerve. A pinched nerve is diagnosed by taking a patient history and performing a physical examination. Electromyography may be performed. Treatment for a pinched nerve depends on the underlying cause.
Postherpetic neuralgia (PHN) is a painful complication of shingles. Symptoms include severe pain, itchy skin, and possible weakness or paralysis of the area. There is no treatment for postherpetic neuralgia that is effective for all patients.
What Causes You to Get Shingles?
Shingles (herpes zoster) is caused by varicella zoster virus, the same virus that causes chickenpox. Sometimes, in patients with a history of chickenpox, the virus may live in the nervous system for years in an inactive form, and then reactivate as shingles.
Treatment & Diagnosis
Medications & Supplements
- Anxiolytics (for Anxiety) Drug Class Side Effects
- Lyrica vs. Gabapentin: Differences between Pain Relief and Uses
- Lyrica (pregabalin) vs. Xanax (alprazolam)
- Lyrica vs. Tramadol
- Lyrica (pregabalin) vs. Topamax (topiramate)
- Lyrica (pregabalin) vs. Savella (milnacipran)
- Lyrica (pregabalin) vs. Cymbalta (duloxetine)
- Lyrica (pregabalin) vs. Norco (hydrocodone and acetaminophen)
- Lyrica (pregabalin) vs. Klonopin (clonazepam)
- Lyrica vs. Hydrocodone
Prevention & Wellness
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information