- Fibromyalgia Overview Slideshow
- Take the Fibromyalgia Quiz
- Fibromyalgia: 12 Tips for Coping Slideshow
- What is Lyrica (pregabalin)?
- Is Lyrica (pregabalin) available as a generic drug?
- Do I need a prescription for Lyrica (pregabalin)?
- Why is Lyrica (pregabalin) prescribed to patients?
- What are the side effects of Lyrica (pregabalin)?
- What is the dosage for Lyrica (pregabalin)?
- Which drugs or supplements interact with Lyrica (pregabalin)?
- Is Lyrica (pregabalin) safe to use during pregnancy or while breastfeeding?
- What else should I know about Lyrica (pregabalin)?
What is Lyrica (pregabalin)?
Lyrica (pregabalin) is an oral medication that is chemically related to gabapentin (Gralise, Neurontin). It is used for treating pain caused by neurologic diseases such as postherpetic neuralgia as well as seizures. It also is used for treating fibromyalgia.
What are the side effects of Lyrica (pregabalin)?
SIDE EFFECTS WARNING:
- Antiepileptic medications have been associated with increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
The most common side effects of Lyrica are
- dry mouth (xerostomia),
- edema (accumulation of fluid),
- blurred vision,
- double vision (diplopia),
- weight gain,
- fatigue (tiredness),
- abnormal gait (ataxia),
- tremor, and
- difficulty concentrating.
Other side effects include
- increased appetite,
- myoclonus (sudden, involuntary jerking of a muscle or muscle groups),
- heart failure,
- low blood pressure,
- reduced blood platelet counts, and
- increased blood creatinine kinase levels.
Increased creatinine kinase can be a sign of muscle injury, and in clinical trials three patients experienced rhabdomyolysis (severe muscle injury). Therefore, patients should report unexplained muscle pain, tenderness or weakness to their doctors, especially if associated with fever and malaise (reduced well-being). Lyrica has rarely been associated with angioedema (swelling of the face, tongue, lips, and gums, throat and larynx).
What is the dosage for Lyrica (pregabalin)?
- Lyrica may be taken with or without food.
- Treating diabetic peripheral neuropathy: The initial dose for neuropathic pain associated with diabetic peripheral neuropathy is 50 mg three times a day (150 mg/day). The dose may be increased to a maximum dose of 100 mg 3 times daily (300 mg/day) after one week.
- Treating postherpetic neuralgia: The recommended dose for postherpetic neuralgia is 75-150 mg twice daily or 50-100 mg three times daily. Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day). The dose may be increased to 100 mg 3 times daily (300 mg/day) after one week. If pain relief is inadequate after 2-4 weeks of treatment at 300 mg/day, the dose may be increased to 300 mg twice daily or 200 mg three times daily. Doses greater than 300 mg cause more side effects.
- Treating neuropathic pain associated with spinal cord injury: The dose for treating neuropathic pain associated with spinal cord injury is 150 to 600 mg daily. Begin dosing at 75 mg two times a day an increase to 150 mg two times daily after one week if response is inadequate. May increase to 300 mg twice daily if response is inadequate after 2 to 3 weeks.
- Treating seizures: The recommended dose for treating seizures is 150-600 mg/day divided into 2 or 3 doses, starting at 150 mg daily and increasing based on response and tolerability. The maximum dose is 600 mg/day.
- Treating fibromyalgia: Fibromyalgia is treated with 300-450 mg/day in 2 or 3 divided doses.
Which drugs or supplements interact with Lyrica (pregabalin)?
- Alcohol and drugs that cause sedation may increase the sedative effects of pregabalin.
- Pioglitazone (Actos) and rosiglitazone (Avandia) cause weight gain, fluid retention, and possibly heart failure. Therefore, combining pregabalin with these drugs may increase the occurrence of weight gain and fluid retention.
What else should I know about Lyrica (pregabalin)?
What preparations of Lyrica (pregabalin) are available?
- Capsules: 25, 50, 75, 100, 150, 200, 225, and 300 mg.
- Oral Solution: 20 mg/ml
How should I keep Lyrica (pregabalin) stored?
- Pregabalin should be stored at room temperature, from 15 C to 30 C (59 F to 86 F).
How does Lyrica (pregabalin) work?
- The mechanism of action of pregabalin is unknown. Pregabalin binds to calcium channels on nerves and may modify the release of neurotransmitters (chemicals that nerves use to communicate with each other). Reducing communication between nerves may contribute to pregabalin's effect on pain and seizures.
When was Lyrica (pregabalin) approved by the FDA?
- The FDA approved pregabalin in December 2004.
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Lyrica (pregabalin) is a drug prescribed for the treatment of neuropathic pain associated with diabetic peripheral neuropathy or post neuralgia; partial onset seizures in adults; and fibromyalgia. Side effects include
- blurred vision,
- double vision (diplopia),
- weight gain,
- fatigue (tiredness),
- increased appetite,
- nausea, and
- intestinal gas.
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