What is pramoxine, and how does it work (mechanism of action)?

Pramoxine is a topical (used on the skin) anesthetic (numbing agent). Topical anesthetics are chemicals that interfere with the function of the nerves that sense pain. Pramoxine may be used in persons who are allergic to other local anesthetics such as lidocaine, procaine, or benzocaine.

Is it available as a generic drug?

Yes, pramoxine is available as a generic drug.

Do I need a prescription for pramoxine?

Yes, you need a prescription from your doctor or other health care professional to obtain this medication.

What are the uses for pramoxine?

This medicine is used for the temporary relief of pain and itching associated with:


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What are the side effects and adverse effects of pramoxine?

In some patients, pramoxine may act as a "sensitizer," and:

What is the dosage for pramoxine?

  • Apply one dose topically to the affected areas 3 to 4 times per day.
  • This drug is intended only for external use and should not be applied to open cuts or wounds or damaged skin.
  • If the condition does not improve after 7 days of use, a doctor, pharmacist, or other health care professional should be consulted.

Which drugs or supplements interact with this medication?

There are no drug interactions listed for this medication.

What brand names are available for pramoxine?

There are numerous brand names for pramoxine, far too many to list here. Examples include:

  • Itch-X
  • PrameGel
  • Orax
  • Sarna Sensitive

The brand Anti-Itch has been discontinued in the US.

Is this drug safe to use during pregnancy or while breastfeeding?

  • Researchers and doctors don't know if pramoxine is harmful if used during pregnancy.
  • Doctors and researchers don't know if pramoxine is secreted into human milk.
  • Consult with your doctor if you are considering using this topical anti-itch cream.

What else should I know about pramoxine?

This medication is available in formulations of:

  • Topical Cream: 1%
  • Topical Gel: 1%
  • Topical Lotion: 1%
  • Topical Spray: 1%

Keep this medication stored at room temperature, 15 C-30 C (59 F-86 F).

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Pramoxine (Itch-X, PramaGel Anti-Itch and others) is a topical anesthetic prescribed for the temporarily relief of pain and itching associated with:

In some patients pramoxine may act as a "sensitizer" and cause side effects of:

  • Worsening of the skin condition
  • Burning or stinging of the skin

Drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to using this drug.

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Medically reviewed by John Cunha, DO

Reference: FDA Prescribing Information