hydrocortisone and pramoxine

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is pramoxine-hydrocortisone-lotion, and how does it work (mechanism of action)?

  • Hydrocortisone/pramoxine topical products are used to treat pain and inflammation caused by various skin conditions. Hydrocortisone is a synthetic (man-made) corticosteroid that is used on the skin (topically). The naturally-occurring corticosteroid is cortisol or hydrocortisone produced by the adrenal gland. Corticosteroids have potent anti-inflammatory actions and also suppress the immune response.
  • Pramoxine is a local anesthetic (numbing agent) that provides relief from itching and pain. Local anesthetics are chemicals that interfere with the function of the nerves that sense pain. Pramoxine may be used in persons who are allergic to other local anesthetics such as lidocaine, procaine, or benzocaine.
  • The FDA approved hydrocortisone/pramoxine in August 1976.

What brand names are available for pramoxine-hydrocortisone-lotion?

Epifoam, Pramosone, Proctofoam HC, Procort, Analpram HC

Is pramoxine-hydrocortisone-lotion available as a generic drug?


Do I need a prescription for pramoxine-hydrocortisone-lotion?


What are the uses for pramoxine-hydrocortisone-lotion?

Topical hydrocortisone and pramoxine is used for

  • the treatment of inflammation and itching caused by various skin conditions; and
  • relieving pain, burning, and inflammation caused by hemorrhoids.

What are the side effects of pramoxine-hydrocortisone-lotion?

Common side effects include:

  • Burning
  • Itching
  • Irritation
  • Dryness
  • Folliculitis

What is the dosage for pramoxine-hydrocortisone-lotion?

  • Hydrocortisone/pramoxine is applied to the affected area as a thin film 3 to 4 times a day depending on the severity of condition.

Which drugs or supplements interact with pramoxine-hydrocortisone-lotion?

There are no drug interactions listed for topical hydrocortisone/pramoxine.


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Is pramoxine-hydrocortisone-lotion safe to take if I'm pregnant or breastfeeding?

  • The use of hydrocortisone/pramoxine by pregnant women has not been adequately evaluated.
  • It is not known if hydrocortisone/pramoxine is secreted in breast milk.

What else should I know about pramoxine-hydrocortisone-lotion?

What preparations of pramoxine-hydrocortisone-lotion are available?

  • Rectal aerosol foam: 1%/1%
  • Cream: 0.5%/1%, 1%/1%, and 2.5%/1%
  • Lotion: 1%/1% and 2.5%/1%

How should I keep pramoxine-hydrocortisone-lotion stored?

  • Hydrocortisone/pramoxine cream and lotion should be stored at room temperature between 15 C and 30 C (59 F and 86 F).
  • The aerosol foam is stored at room temperature, between 20 C and 25 C (68 F and 77 F).


Topical hydrocortisone and pramoxine (Epifoam, Pramosone, Proctofoam HC, Procort, Analpram HC) is a prescription medication used to treat inflammation and itching caused by skin conditions; and to relieve the pain, inflammation, and burning caused by hemorrhoids. Side effects, drug interactions, warnings, dosing, and pregnancy and breastfeeding information should be provided prior to using any drug or supplement.

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