Prader-Willi Syndrome: Symptoms & Signs

Medically Reviewed on 4/28/2020

Prader-Willi syndrome is a complex genetic condition that affects many different areas of the body and functions.

Signs and symptoms of Prader-Willi syndrome include

Behavioral problems are common, including

Many of those affected also have sleep problems. Other symptoms can include

Most affected people are infertile.

Causes of Prader-Willi syndrome

The loss of genes in a specific region of chromosome 15 from the paternal copy (the gene that was inherited from the father) causes Prader-Willi syndrome. However, most cases of Prader-Willi syndrome are not inherited. Instead, the genetic changes occur as random events during the formation of reproductive cells (eggs and sperm) or in early embryonic development.

Other prader-willi syndrome symptoms and signs

  • Aggression
  • Compulsive Behavior
  • Distinctive Facial Features
  • Learning Disabilities
  • Mild to Moderate Intellectual Impairment
  • Short Stature
  • Small Hands and Feet
  • Stubbornness
  • Temper Tantrums

Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.