Plexiform Neurofibroma: Symptoms & Signs

A plexiform neurofibroma is a tumor the arises in the tissue that covers and protects nerves in the body outside the brain and spinal cord. Plexiform neurofibromas represent an uncommon variant of the genetic condition neurofibromatosis type 1 (NF1) in which neurofibromas arise from multiple nerves. Most plexiform neurofibromas are benign but some may become malignant.

Plexiform neurofibromas can occur in various locations throughout the body, including the face, chest, abdomen, back, neck, extremities, or internal organs. Symptoms depend on the tumor's location and size and can include

• severe pain,
• vision loss,
• weakness,
• mobility problems,
• disfigurement, or
• hearing loss.

The tumors can involve connective tissue and skin folds and take on a "bag of worms" appearance.

Cause of a Plexiform Neurofibroma

A genetic mutation causes plexiform neurofibroma.

Other plexiform neurofibroma symptoms and signs

• Disfigurement
• Hearing Loss
• Mobility Problems
• Severe Pain
• Vision Loss
• Weakness

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